High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma

Hou,Wenmin; Fei,Maogui; Qin,Xia; Zhu,Xuehua; Greshock,Joel; Liu,Ping; Zhou,Yuanfeng; Wang,Hui; Ye,Bang-Ce; Qin,Crystal  Ying

doi:10.3892/etm.2012.727

High overexpression of fatty acid synthase is associated with poor survival in Chinese patients with gastric carcinoma

Authors:
- Wenmin Hou
- Maogui Fei
- Xia Qin
- Xuehua Zhu
- Joel Greshock
- Ping Liu
- Yuanfeng Zhou
- Hui Wang
- Bang-Ce Ye
- Crystal Ying Qin
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Affiliations: Laboratory of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, P.R. China, Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, P.R. China , Department of Oncology, GlaxoSmithKline Research and Development Center, Shanghai, P.R. China, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, P.R. China, Cancer Research, GlaxoSmithKline, Collegeville, PA, USA
Published online on: September 27, 2012 https://doi.org/10.3892/etm.2012.727
Pages: 999-1004

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Abstract

Fatty acid synthase (FAS) is the key enzyme regulating de novo biosynthesis of fatty acids. FAS overexpression has been found in many types of tumors and is associated with poor survival. However, the expression of FAS and its relationship with prognosis in Chinese patients with gastric carcinoma are still unknown. Therefore, in this study, we examined the expression of FAS using tissue microarrays and determined its correlation with clinicopathological characteristics and prognosis of gastric carcinoma in Chinese patients. FAS overexpression was graded as S (T/A) <1, ≥1 to <2, ≥2 to <3 or ≥3 in 35 (38.9%), 20 (22.2%), 9 (10%) and 26 (28.9%) patients, respectively. High FAS overexpression [S (T/A) ≥3] was significantly correlated with poor prognosis (log-rank test, P=0.0078) and with decreased 3-year survival rate (χ2 test, P=0.0023). FAS overexpression was not significantly associated with other clinicopathological characteristics. In conclusion, our results suggest that FAS expression might be a potential prognostic marker for gastric carcinoma in Chinese patients.

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