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Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis

  • Authors:
    • Shi Yan
    • Yong-Zhi Li
    • Xin-Wang Zhu
    • Chun-Lai Liu
    • Ping Wang
    • Yi-Li Liu

  • View Affiliations

  • Published online on: October 19, 2012     https://doi.org/10.3892/etm.2012.756
  • Pages: 175-180
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Abstract

Failure of apoptosis is one of the hallmarks of cancer. As an execution-phase caspase, caspase-9 plays a crucial role during apoptosis. To examine whether the Ex5+32 G>A (rs1052576) polymorphism in the CASP-9 gene alters cancer risk, we conducted a comprehensive meta-analysis of 7 case-control studies consisting of a total of 1668 cancer cases and 2294 healthy controls. All studies considered, A allele and A allele carriers of Ex5+32 G>A in the CASP-9 gene had significant associations with cancer risk (OR=0.72, 95% CI, 0.58-0.89, P=0.003; OR=0.76, 95% CI, 0.63-0.92, P=0.004; respectively). In the subgroup analysis, we found that the A allele of Ex5+32 G>A was a protective factor for cancer risk in Chinese and American populations (OR=0.60, 95% CI, 0.44-0.81, P<0.001; OR=0.80, 95% CI, 0.69-0.94, P=0.005; respectively). Similarly, we also found positive associations between A allele carriers of Ex5+32 G>A and cancer risk in Chinese and American populations (OR=0.63, 95% CI, 0.44-0.90, P=0.01; OR=0.78, 95% CI, 0.62-0.98, P=0.03; respectively). In addition, we identified that A allele and A allele carriers of Ex5+32 G>A may decrease the risk of cancer in the Asian population (OR=0.60, 95% CI, 0.44-0.81, P<0.001; OR=0.63, 95% CI, 0.44-0.90, P=0.01; respectively). In conclusion, this meta-analysis demonstrated that A allele and A allele carriers of the Ex5+32 G>A polymorphism in the CASP-9 gene may be protective factors for cancer risk.
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January 2013
Volume 5 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yan S, Li Y, Zhu X, Liu C, Wang P and Liu Y: Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis. Exp Ther Med 5: 175-180, 2013.
APA
Yan, S., Li, Y., Zhu, X., Liu, C., Wang, P., & Liu, Y. (2013). Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis. Experimental and Therapeutic Medicine, 5, 175-180. https://doi.org/10.3892/etm.2012.756
MLA
Yan, S., Li, Y., Zhu, X., Liu, C., Wang, P., Liu, Y."Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis". Experimental and Therapeutic Medicine 5.1 (2013): 175-180.
Chicago
Yan, S., Li, Y., Zhu, X., Liu, C., Wang, P., Liu, Y."Role of the CASP-9 Ex5+32 G>A polymorphism in susceptibility to cancer: A meta-analysis". Experimental and Therapeutic Medicine 5, no. 1 (2013): 175-180. https://doi.org/10.3892/etm.2012.756