The prognostic value of copeptin for acute intracerebral hemorrhage patients

Zhang,Aimei; Li,Jun; Li,Xiaoyun; Song,Li; Li,Hongfang

doi:10.3892/etm.2012.804

The prognostic value of copeptin for acute intracerebral hemorrhage patients

Authors:
- Aimei Zhang
- Jun Li
- Xiaoyun Li
- Li Song
- Hongfang Li
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Affiliations: Department of Neurology, Affiliated Hospital of Ji Ning Medical University, Jining 272029, P.R. China, Graduate School of Tianjin Medical University, Tianjin 300070, P.R. China
Published online on: November 7, 2012 https://doi.org/10.3892/etm.2012.804
Pages: 467-470

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Abstract

The aim of the current study was to examine the prognostic value of copeptin for acute intracerebral hemorrhage (ICH) patients. A total of 120 patients were recruited. The plasma copeptin levels were measured using sandwich immunoassays. The hematoma volume, Glasgow coma scale (GCS) and ICH score were evaluated. The 90-day functional outcomes were measured with the modified Rankin scale (mRS). Copeptin correlated positively with hematoma volume (r=0.61, P=0.000), Hemphill scores (r=0.78, P=0.000) and white blood cell counts (r=0.58, P=0.000), whereas copeptin correlated negatively with GCS scores (r=-0.79, P=0.000). Copeptin levels were also higher in patients with an unfavorable functional outcome at 90 days than in patients with a favorable outcome (4.14±0.87 vs. 3.09±0.30 ng/ml; t=8.001, P=0.00). Monovariate logistic regression analysis results suggest that copeptin is a predictor of the 90-day functional outcomes of ICH patients (OR=3.17, 95% CI 2.01-4.35, P=0.003. Multivariate logistic regression analysis results indicate that copeptin is an independent predictor of the 90-day functional outcomes of ICH patients.

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1.	Zhao D, Liu J, Wang W, et al: Epidemiological transition of stroke in China: twenty-one-year observational study from the Sino-MONICA-Beijing Project. Stroke. 39:1668–1674. 2008.PubMed/NCBI
2.	Johnston SC: Clinical practice. Transient ischemic attack. N Engl J Med. 347:1687–1692. 2002. View Article : Google Scholar : PubMed/NCBI
3.	Delgado P, Alvarez Sabin J, Montaner J, et al: Biological markers in spontaneous intracerebral hemorrhage. Neurologia. 22:448–455. 2007.(In Spanish).
4.	Johansson A, Olsson T, Carlberg B, et al: Hypercortisolism after stroke-partly cytokine-mediated? J Neurol Sci. 147:43–47. 1997. View Article : Google Scholar : PubMed/NCBI
5.	Volpi S, Rabadan-Diehl C and Aguilera G: Vasopressinergic regulation of the hypothalamic pituitary adrenal axis and stress adaptation. Stress. 7:75–83. 2004. View Article : Google Scholar : PubMed/NCBI
6.	Alvarez-Sabin J, Delgado P, Abilleira S, et al: Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke. 35:1316–1322. 2004. View Article : Google Scholar
7.	Singh RG: The physiology and emerging roles of antidiuretic hormone. Int J Clin Pract. 56:777–782. 2002.PubMed/NCBI
8.	Morgenthaler NG, Struck J, Alonso C, et al: Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem. 52:112–119. 2006. View Article : Google Scholar : PubMed/NCBI
9.	Barat C, Simpson L, Breslow E, et al: Properties of human vasopressin precursor constructs inefficient monomer folding in the absence of copeptin as a potential contributor to diabetes insipidus. Biochemistry. 43:8191–8203. 2004. View Article : Google Scholar
10.	Jochberger S, Morgenthaler NG, Mayr VD, et al: Copeptin and arginine vasopressin concentrations in critically ill patients. J Clin Endocrinol Metab. 91:4381–4386. 2006. View Article : Google Scholar : PubMed/NCBI
11.	Neuhold S, Huelsmann M, Strunk G, et al: Comparison of copeptin, B-type natriuretic peptide, and amino-terminal pro-B-type natriuretic peptide in patients with chronic heart failure: prediction of death at different stages of the disease. J Am Coll Cardiol. 52:266–272. 2008. View Article : Google Scholar : PubMed/NCBI
12.	Voors AA, von Haehling S, Anker SD, et al: C-terminal provasopressin (copeptin) is a strong prognostic marker in patients with heart failure after an acute myocardial infarction: results from the OPTIMAAL study. Eur Heart J. 30:1187–1194. 2009. View Article : Google Scholar
13.	Katan M and Christ-Crain M: The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly. 140:w131012010.PubMed/NCBI
14.	Katan M, Fluri F, Morgenthaler NG, et al: Copeptin: a novel, independent prognostic marker in patients with ischemic stroke. Ann Neurol. 66:799–808. 2009. View Article : Google Scholar : PubMed/NCBI
15.	Katan M, Morgenthaler N, Widmer I, et al: Copeptin, a stable peptide derived from the vasopressin precursor, correlates with the individual stress level. Neuro Endocrinol Lett. 29:341–346. 2008.PubMed/NCBI
16.	Zweifel C, Katan M, Schuetz P, et al: Copeptin is associated with mortality and outcome in patients with acute intracerebral hemorrhage. BMC Neurol. 10:342010. View Article : Google Scholar : PubMed/NCBI
17.	Stolz D, Christ-Crain M, Morgenthaler NG, et al: Copeptin, c-reactive protein and procalcitonin as prognostic biomarkers in acute exacerbation of COPD. Chest. 131:1058–1067. 2007. View Article : Google Scholar : PubMed/NCBI
18.	Urwyler SA, Schuetz P, Fluri F, et al: Prognostic value of copeptin one-year outcome in patients with acute stroke. Stroke. 41:1564–1567. 2010.PubMed/NCBI