Influence of racemic higenamine on the sinus node

Yu,Fengxia; Kong,Lingting; Wang,Shujuan

doi:10.3892/etm.2012.813

Influence of racemic higenamine on the sinus node

Authors:
- Fengxia Yu
- Lingting Kong
- Shujuan Wang
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Affiliations: Department of Emergency Medicine, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China, Electrocardiogram room, Yantaishan Hospital, Yantai, Shandong 264001, P.R. China
Published online on: November 15, 2012 https://doi.org/10.3892/etm.2012.813
Pages: 591-595

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Abstract

The aim of this study was to explore the mechanism of racemic higenamine in the treatment of sick sinus syndrome (SSS). A total of 40 New Zealand rabbits were randomly divided into normal sinus node and damaged sinus node (SND) groups, and each group was randomly divided into treatment and control groups (n=10). The SND model was established by formaldehyde wet dressing of the sinus node area. The treatment groups were administered an intravenous infusion of 0.04 mg/kg racemic higenamine via the marginal ear vein within 5 min. The electrophysiological indicators of sinoatrial function, including the sinus node recovery time (SNRT), corrected sinus node recovery time (CSNRT), total sinoatrial conduction time (TSACT) and sinus cycle length (SCL), were determined before and 20 min after medication and the changes in these indicators were evaluated. The two control groups were administered 10 ml physiological saline. Following the administration of racemic higenamine, the SNRT, CSNRT, TSACT and SCL in the normal sinus node and SND groups were significantly shortened compared with those in the control groups (P<0.01). The electrophysiological influence of racemic higenamine on sinoatrial function in the SND group was significantly greater than that in the normal sinus node group (P<0.01), and its effect in the treatment of arrhythmia caused by a damaged sinus node was statistically significant (P<0.05). The main electrophysiological mechanism of racemic higenamine in the treatment of SSS was the enhancement of sinus node self-discipline and improvement of sinoatrial and atrioventricular conduction function.

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1.	Da Costa A, Kirkorian G, Cucherat M, et al: Antibiotic prophylaxis for permanent pacemaker implantation: a meta-analysis. Circulation. 97:1796–1801. 1998.PubMed/NCBI
2.	Bai G, Yang Y, Shi Q, Liu Z, Zhang Q and Zhu YY: Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1. Acta Pharmacol Sin. 29:1187–1194. 2008. View Article : Google Scholar : PubMed/NCBI
3.	Pyo MK, Lee DH, Kim DH, et al: Enantioselective synthesis of (R)-(+)- and (S)-(-)-higenamine and their analogues with effects on platelet aggregation and experimental animal model of disseminated intravascular coagulation. Bioorg Med Chem Lett. 18:4110–4114. 2008.
4.	Pyo MK, Kim JM, Jin JL, Chang KC, Lee DH and Yun-Choi HS: Effects of higenamine and its 1-naphthyl analogs, YS-49 and YS-51, on platelet TXA2 synthesis and aggregation. Thromb Res. 120:81–86. 2007. View Article : Google Scholar : PubMed/NCBI
5.	Praman S, Mulvany MJ, Williams DE, Andersen RJ and Jansakul C: Hypotensive and cardio-chronotropic constituents of Tinospora crispa and mechanisms of action on the cardiovascular system in anesthetized rats. J Ethnopharmacol. 140:166–178. 2012.PubMed/NCBI
6.	Narula OS, Samet P and Javier RP: Significance of the sinus-node recovery time. Circulation. 45:140–158. 1972. View Article : Google Scholar : PubMed/NCBI
7.	Narula OS, Shantha N, Vasquez M, Towne WD and Linhart JW: A new method for measurement of sinoatrial conduction time. Circulation. 58:706–714. 1978. View Article : Google Scholar : PubMed/NCBI
8.	Sealy WC, Bache RJ, Seaber AV and Bhattacharga SK: The atrial pacemaking site after surgical exclusion of the sinoatrial node. J Thorac Cardiovasc Surg. 65:841–850. 1973.PubMed/NCBI
9.	Zhou SH, Song ZY, Yao Q and Li YH: Dynamic state of electrophysiology function of sinoatrial node after its constitution damaged acutely. Chin J Cardiac Pacing Electrophysiol. 18:127–129. 2004.(In Chinese).
10.	Li YK: Methodology of Pharmacological Experiment for the Traditional Chinese Medicine. Shanghai Scientific and Technology Press; Shanghai: pp. 2831991, (In Chinese).
11.	Liu W, Sato Y, Hosoda Y, Hirasawa K and Hanai H: Effects of higenamine on regulation of ion transport in guinea pig distal colon. Jpn J Pharmacol. 84:244–251. 2000. View Article : Google Scholar : PubMed/NCBI
12.	Yu GR, Qiao SY, Zheng DS, Huang MX and Bian YT: Effect of higenamine on action potential of Purkinje's cells and ventricular myocardial cells in dogs. J Tradit Chin Med. 4:133–140. 1984.
13.	Kimura I, Makino M, Takamura Y, Islam MA and Kimura M: Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. Jpn J Pharmacol. 66:75–80. 1994. View Article : Google Scholar : PubMed/NCBI
14.	Chong WS, Lee YS, Kang YJ, et al: Comparison of inodilator effect of higenamine, YS49, YS51, tetra hydroisoquinoline analogs, and dobutamine in the rat. Korean J Physiol Pharmacol. 2:323–330. 1998.
15.	Wong KK, Lo CF and Chen CM: Endothelium-dependent higenamine-induced aortic relaxation in isolated rat aorta. Planta Med. 63:130–132. 1997. View Article : Google Scholar : PubMed/NCBI
16.	Lee YS, Kang YJ, Kim HJ, et al: Higenamine reduces apoptotic cell death by induction of heme oxygenase-1 in rat myocardial ischemia-reperfusion injury. Apoptosis. 11:1091–1100. 2006. View Article : Google Scholar : PubMed/NCBI
17.	Yun-Choi HS, Pyo MK, Park KM, Chang KC and Lee DH: Anti-thrombotic effects of higenamine. Planta Med. 67:619–622. 2001. View Article : Google Scholar
18.	Yun-Choi HS, Pyo MK, Chang KC and Lee DH: The effects of higenamine on LPS-induced experimental disseminated intravascular coagulation (DIC) in rats. Planta Med. 68:326–329. 2002. View Article : Google Scholar : PubMed/NCBI
19.	Ha YM, Kim MY, Park MK, et al: Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 17:463–474. 2012. View Article : Google Scholar : PubMed/NCBI
20.	Ueki T, Akaishi T, Okumura H and Abe K: Extract from Nandina domestica inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in human pulmonary epithelial A549 cells. Biol Pharm Bull. 35:1041–1047. 2012.
21.	Park JE, Kang YJ, Park MK, et al: Enantiomers of higenamine inhibit LPS-induced iNOS in a macrophage cell line and improve the survival of mice with experimental endotoxemia. Int Immunopharmacol. 6:226–233. 2006. View Article : Google Scholar : PubMed/NCBI