Cardiac stem cells: A promising treatment option for heart failure (Review)
- Authors:
- Xiaohui Zhao
- Lan Huang
-
Affiliations: Department of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China - Published online on: December 5, 2012 https://doi.org/10.3892/etm.2012.854
- Pages: 379-383
This article is mentioned in:
Abstract
Chien KR and Olson EN: Converging pathways and principles in heart development and disease: CV@CSH. Cell. 110:153–162. 2002. View Article : Google Scholar : PubMed/NCBI | |
MacLellan WR and Schneider MD: Genetic dissection of cardiac growth control pathways. Annu Rev Physiol. 62:289–319. 2000. View Article : Google Scholar : PubMed/NCBI | |
Anversa P, Rota M, Urbanek K, et al: Myocardial aging - a stem cell problem. Basic Res Cardiol. 100:482–493. 2005. View Article : Google Scholar : PubMed/NCBI | |
Beltrami AP, Barlucchi L, Torella D, et al: Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 114:763–776. 2003. View Article : Google Scholar : PubMed/NCBI | |
Martin CM, Meeson AP, Robertson SM, et al: Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart. Dev Biol. 265:262–275. 2004. View Article : Google Scholar : PubMed/NCBI | |
Matsuura K, Nagai T, Nishigaki N, et al: Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes. J Biol Chem. 279:11384–11391. 2004. View Article : Google Scholar : PubMed/NCBI | |
Oh H, Bradfute SB, Gallardo TD, et al: Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc Natl Acad Sci USA. 100:12313–12318. 2003. View Article : Google Scholar : PubMed/NCBI | |
Linke A, Müller P, Nurzynska D, et al: Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci USA. 102:8966–8971. 2005. View Article : Google Scholar : PubMed/NCBI | |
Messina E, De Angelis L, Frati G, et al: Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res. 95:911–921. 2004. View Article : Google Scholar : PubMed/NCBI | |
Balsam LB, Wagers AJ, Christensen JL, et al: Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature. 428:668–673. 2004. View Article : Google Scholar : PubMed/NCBI | |
Fuchs S, Baffour R, Zhou YF, et al: Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol. 37:1726–1732. 2001. View Article : Google Scholar | |
Kamihata H, Matsubara H, Nishiue T, et al: Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation. 104:1046–1052. 2001. View Article : Google Scholar | |
Kocher AA, Schuster MD, Szabolcs MJ, et al: Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med. 7:430–436. 2001. View Article : Google Scholar | |
Orlic D, Kajstura J, Chimenti S, et al: Bone marrow cells regenerate infarcted myocardium. Nature. 410:701–705. 2001. View Article : Google Scholar : PubMed/NCBI | |
Schuster MD, Kocher AA, Seki T, et al: Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration. Am J Physiol Heart Circ Physiol. 287:H525–H532. 2004. View Article : Google Scholar : PubMed/NCBI | |
Beltrami AP, Urbanek K, Kajstura J, et al: Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med. 344:1750–1757. 2001. View Article : Google Scholar : PubMed/NCBI | |
Kajstura J, Leri A, Finato N, et al: Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA. 95:8801–8805. 1998. View Article : Google Scholar : PubMed/NCBI | |
Quaini F, Cigola E, Lagrasta C, et al: End-stage cardiac failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. Circ Res. 75:1050–1063. 1994. View Article : Google Scholar : PubMed/NCBI | |
Urbanek K, Quaini F, Tasca G, et al: Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci USA. 100:10440–10445. 2003. View Article : Google Scholar : PubMed/NCBI | |
Anversa P, Leri A, Rota M, et al: Concise review: stem cells, myocardial regeneration, and methodological artifacts. Stem Cells. 25:589–601. 2007. View Article : Google Scholar : PubMed/NCBI | |
Olivetti G, Cigola E, Maestri R, et al: Aging, cardiac hypertrophy and ischemic cardiomyopathy do not affect the proportion of mononucleated and multinucleated myocytes in the human heart. J Mol Cell Cardiol. 28:1463–1477. 1996. View Article : Google Scholar | |
Anversa P, Kajstura J, Leri A and Bolli R: Life and death of cardiac stem cells: a paradigm shift in cardiac biology. Circulation. 113:1451–1463. 2006. View Article : Google Scholar : PubMed/NCBI | |
Urbanek K, Cesselli D, Rota M, et al: Stem cell niches in the adult mouse heart. Proc Natl Acad Sci USA. 103:9226–9231. 2006. View Article : Google Scholar : PubMed/NCBI | |
Nadal-Ginard B, Kajstura J, Leri A and Anversa P: Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res. 92:139–150. 2003. View Article : Google Scholar : PubMed/NCBI | |
Bayes-Genis A, Salido M, Solé Ristol F, et al: Host cell-derived cardiomyocytes in sex-mismatch cardiac allografts. Cardiovasc Res. 56:404–410. 2002. View Article : Google Scholar : PubMed/NCBI | |
Deb A, Wang S, Skelding KA, et al: Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients. Circulation. 107:1247–1249. 2003. View Article : Google Scholar : PubMed/NCBI | |
Glaser R, Lu MM, Narula N and Epstein JA: Smooth muscle cells, but not myocytes, of host origin in transplanted human hearts. Circulation. 106:17–19. 2002. View Article : Google Scholar : PubMed/NCBI | |
Quaini F, Urbanek K, Beltrami AP, et al: Chimerism of the transplanted heart. N Engl J Med. 346:5–15. 2002. View Article : Google Scholar : PubMed/NCBI | |
Rosenthal N: Prometheus’s vulture and the stem-cell promise. N Engl J Med. 349:267–274. 2003. | |
Kondo M, Wagers AJ, Manz MG, et al: Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu Rev Immunol. 21:759–806. 2003. View Article : Google Scholar : PubMed/NCBI | |
Morrison SJ, Wandycz AM, Akashi K, et al: The aging of hematopoietic stem cells. Nat Med. 2:1011–1016. 1996. View Article : Google Scholar : PubMed/NCBI | |
Smart N and Riley PR: The stem cell movement. Circ Res. 102:1155–1168. 2008. View Article : Google Scholar : PubMed/NCBI | |
Sellers SE, Tisdale JF, Agricola BA, et al: The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells. Blood. 97:1888–1891. 2001. View Article : Google Scholar : PubMed/NCBI | |
Moretti A, Lam J, Evans SM and Laugwitz KL: Biology of Isl1+ cardiac progenitor cells in development and disease. Cell Mol Life Sci. 64:674–682. 2007. | |
Moretti A, Caron L, Nakano A, et al: Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle and endothelial cell diversification. Cell. 127:1151–1165. 2006. | |
Lev S, Yarden Y and Givol D: Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor. J Biol Chem. 267:15970–15977. 1992.PubMed/NCBI | |
van de Rijn M, Heimfeld S, Spangrude GJ and Weissman IL: Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family. Proc Natl Acad Sci USA. 86:4634–4638. 1989.PubMed/NCBI | |
Durocher D, Charron F, Warren R, et al: The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. EMBO J. 16:5687–5696. 1997. View Article : Google Scholar : PubMed/NCBI | |
Grépin C, Robitaille L, Antakly T and Nemer M: Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol Cell Biol. 15:4095–4102. 1995.PubMed/NCBI | |
Yamamoto K, Burnett JC Jr, Jougasaki M, et al: Superiority of brain natriuretic peptide as a hormonal marker of ventricular systolic and diastolic dysfunction and ventricular hypertrophy. Hypertension. 28:988–994. 1996. View Article : Google Scholar | |
Sheng Z, Pennica D, Wood WI and Chien KR: Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survival. Development. 122:419–428. 1996.PubMed/NCBI | |
Asai S, Saito Y, Kuwahara K, et al: The heart is a source of circulating cardiotrophin-1 in humans. Biochem Biophys Res Commun. 279:320–323. 2000.PubMed/NCBI | |
Mahdavi V, Periasamy M and Nadal-Ginard B: Molecular characterization of two myosin heavy chain genes expressed in the adult heart. Nature. 297:659–664. 1982. View Article : Google Scholar : PubMed/NCBI | |
Michel T and Feron O: Nitric oxide synthases: which, where, how, and why? J Clin Invest. 100:2146–2152. 1997. View Article : Google Scholar : PubMed/NCBI | |
Bearzi C, Rota M, Hosoda T, et al: Human cardiac stem cells. Proc Natl Acad Sci USA. 104:14068–14073. 2007. View Article : Google Scholar : PubMed/NCBI | |
Urbanek K, Rota M, Cascapera S, et al: Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res. 97:663–673. 2005. View Article : Google Scholar | |
Anderson CD, Heydarkhan-Hagvall S, Schenke-Layland K, et al: The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury. J Surg Res. 148:164–171. 2008. View Article : Google Scholar : PubMed/NCBI | |
Rota M, Padin-Iruegas ME, Misao Y, et al: Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res. 103:107–116. 2008. View Article : Google Scholar | |
Chimenti I, Smith RR, Li TS, et al: Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res. 106:971–980. 2010. View Article : Google Scholar | |
Markel TA, Wang Y, Herrmann JL, et al: VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function. Am J Physiol Heart Circ Physiol. 295:H2308–H2314. 2008. View Article : Google Scholar : PubMed/NCBI | |
Matsuura K, Honda A, Nagai T, et al: Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice. J Clin Invest. 119:2204–2217. 2009.PubMed/NCBI | |
Burchfield JS, Iwasaki M, Koyanagi M, et al: Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res. 103:203–211. 2008. View Article : Google Scholar : PubMed/NCBI | |
Gnecchi M, Zhang Z, Ni A and Dzau VJ: Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res. 103:1204–1219. 2008. View Article : Google Scholar : PubMed/NCBI | |
Morimoto H, Takahashi M, Izawa A, et al: Cardiac overexpression of monocyte chemoattractant protein-1 in transgenic mice prevents cardiac dysfunction and remodeling after myocardial infarction. Circ Res. 99:891–899. 2006. View Article : Google Scholar | |
Sadat S, Gehmert S, Song YH, et al: The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem Biophys Res Commun. 363:674–679. 2007. View Article : Google Scholar : PubMed/NCBI | |
Zohlnhöfer D, Dibra A, Koppara T, et al: Stem cell mobilization by granulocyte colony-stimulating factor for myocardial recovery after acute myocardial infarction: a meta-analysis. J Am Coll Cardiol. 51:1429–1437. 2008. | |
Ballard VL: Stem cells for heart failure in the aging heart. Heart Fail Rev. 15:447–456. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kretlow JD, Jin YQ, Liu W, et al: Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells. BMC Cell Biol. 9:602008. View Article : Google Scholar : PubMed/NCBI | |
Smith AL, Ellison FM, McCoy JP Jr and Chen J: c-Kit expression and stem cell factor-induced hematopoietic cell proliferation are up-regulated in aged B6D2F1 mice. J Gerontol A Biol Sci Med Sci. 60:448–456. 2005. View Article : Google Scholar : PubMed/NCBI | |
Joulin O, Petillot P, Labalette M, et al: Cytokine profile of human septic shock serum inducing cardiomyocyte contractile dysfunction. Physiol Res. 56:291–297. 2007.PubMed/NCBI | |
Müller AC: Wirkung auf Herzmuskelzellen aus spontan hypertensiven Ratten und nach antihypertensiver Therapie. Die parakrine Wirkung kardialer Progenitorzellen auf die kontraktile Funktion von Kardiomyozyten. VVB Laufersweiler Verlag Publishing; Germany: pp. 81–84. 2010, (In German). | |
Leri A, Kajstura J and Anversa P: Role of Cardiac Stem Cells in Cardiac Pathophysiology: Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ Res. 109:941–961. 2011. View Article : Google Scholar : PubMed/NCBI | |
Schächinger V, Erbs S, Elsässer A, et al: Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 355:1210–1221. 2006. | |
Wollert KC, Meyer GP, Lotz J, et al: Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 364:141–148. 2004. View Article : Google Scholar : PubMed/NCBI | |
Perin EC, Dohmann HF, Borojevic R, et al: Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation. 107:2294–2302. 2003. View Article : Google Scholar : PubMed/NCBI | |
Dimmeler S, Burchfield J and Zeiher AM: Cell-based therapy of myocardial infarction. Arterioscler Thromb Vasc Biol. 28:208–216. 2008. View Article : Google Scholar : PubMed/NCBI |