A clinical trial report of autologous bone marrow‑derived mesenchymal stem cell transplantation in patients with spinal cord injury

Jiang,Pu-Cha; Xiong,Wen-Ping; Wang,Ge; Ma,Chao; Yao,Wei-Qi; Kendell,Steven  F.; Mehling,Brian  M.; Yuan,Xian-Hou; Wu,Dong-Cheng

doi:10.3892/etm.2013.1083

A clinical trial report of autologous bone marrow‑derived mesenchymal stem cell transplantation in patients with spinal cord injury

Authors:
- Pu-Cha Jiang
- Wen-Ping Xiong
- Ge Wang
- Chao Ma
- Wei-Qi Yao
- Steven F. Kendell
- Brian M. Mehling
- Xian-Hou Yuan
- Dong-Cheng Wu
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Affiliations: Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China, Biochemistry Institute, Wuhan University, Wuhan, Hubei 430071, P.R. China, Blue Horizon International, LLC, New York, NY 10014, USA, Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
Published online on: April 29, 2013 https://doi.org/10.3892/etm.2013.1083
Pages: 140-146

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Abstract

Spinal cord injury (SCI) is a severe neurological disease. An effective strategy for the treatment of SCI is urgently required. Stem cell transplantation has emerged as a viable therapeutic option with great potential for restoring neurological function lost following SCI. From 2009 to 2010, a total of 20 SCI patients were enrolled in a clinical trial by Wuhan Hongqiao Brain Hospital; all patients completed and signed informed consent prior to autologous bone marrow‑derived mesenchymal stem cell transplantation. Analysis of subsequent treatment results indicated significant improvements in sensory, motor and autonomic nerve function as assessed by the American Spinal Injury Association's impairment scale. Thirty days after transplantation, a total of 15 patients (75%) demonstrated improvement, including four of the eight patients (50%) with grade A SCI, three of the four patients (75%) with grade B injury and all eight patients (100%) with grade C injury. The most common adverse events, fever and headache, disappeared within 24‑48 h without treatment.

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1.	Barnabé-Heider F and Frisén J: Stem cells for spinal cord repair. Cell Stem Cell. 3:16–24. 2008.
2.	Lim PA and Tow AM: Recovery and regeneration after spinal cord injury: a review and summary of recent literature. Ann Acad Med Singapore. 36:49–57. 2007.PubMed/NCBI
3.	Goldman S: Stem and progenitor cell-based therapy of the human central nervous system. Nat Biotechnol. 23:862–871. 2005. View Article : Google Scholar : PubMed/NCBI
4.	Harting MT, Baumgartner JE, Worth LL, et al: Cell therapies for traumatic brain injury. Neurosurg Focus. 24:E182008. View Article : Google Scholar : PubMed/NCBI
5.	Park HC, Shim YS, Ha Y, et al: Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor. Tissue Eng. 11:913–922. 2005. View Article : Google Scholar : PubMed/NCBI
6.	Zhao CH: Theory, Technology and Clinical of Stem Cells. Beijing: Chemical Industry Press, Beijing; 2006
7.	Satake K, Lou J and Lenke LG: Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue. Spine (Phila Pa 1976). 29:1971–1979. 2004. View Article : Google Scholar : PubMed/NCBI
8.	Koda M, Nishio Y, Kamada T, et al: Granulocyte colony stimulating (G-CSF) mobilizes bone marrow-derived cells into injured spinal cord and promotes functional recovery after compression-induced spinal cord injury in mice. Brain Res. 1149:223–231. 2007. View Article : Google Scholar
9.	Parr AM, Kulbatski I, Zahir T, et al: Transplanted spinal cord-derived neural stem/progenitor cells promote early functional recovery after rat spinal cord injury. Neuroscience. 155:760–770. 2008. View Article : Google Scholar : PubMed/NCBI
10.	Julia PE and Othman AS: Barriers to sexual activity: counselling spinal cord injured women in Malaysia. Spinal Cord. 49:791–794. 2011. View Article : Google Scholar : PubMed/NCBI
11.	Wrigley PJ, Press SR, Gustin SM, et al: Neuropathic pain and primary somatosensory cortex reorganization following spinal cord injury. Pain. 141:52–59. 2009. View Article : Google Scholar : PubMed/NCBI
12.	Kim HS, Kim NH, Lee HM, Park HW, Ha JW and Park JO: Sexual dysfunction in men with paraparesis in lumbar burst fractures. Spine (Phila Pa 1976). 25:2187–2190. 2000. View Article : Google Scholar : PubMed/NCBI
13.	Park WB, Kim SY, Lee SH, Kim HW, Park JS and Hyun JK: The effect of mesenchymal stem cell transplantation on the recovery of bladder and hindlimb function after spinal cord contusion in rats. BMC Neurosci. 11:1192010. View Article : Google Scholar : PubMed/NCBI
14.	Novikova LN, Brohlin M, Kingham PJ, Novikov LN and Wiberg M: Neuroprotective and growth-promoting effects of bone marrow stromal cells after cervical spinal cord injury in adult rats. Cytotherapy. 13:873–887. 2011. View Article : Google Scholar : PubMed/NCBI
15.	Mothe AJ, Bozkurt G, Catapano J, et al: Intrathecal transplantation of stem cells by lumbar puncture for thoracic spinal cord injury in the rat. Spinal Cord. 49:967–973. 2011. View Article : Google Scholar : PubMed/NCBI
16.	Nishida H, Nakayama M, Tanaka H, et al: Evaluation of transplantation of autologous bone marrow stromal cells into the cerebrospinal fluid for treatment of chronic spinal cord injury in dogs. Am J Vet Res. 72:1118–1123. 2011. View Article : Google Scholar : PubMed/NCBI
17.	Deng YB, Yuan QT, Liu XG, et al: Functional recovery after rhesus monkey spinal cord injury by transplantation of bone marrow mesenchymal-stem cell-derived neurons. Chin Med J (Engl). 118:1533–1541. 2005.PubMed/NCBI
18.	Yoon SH, Shim YS, Park YH, et al: Complete spinal cord injury treatment using autologous bone marrow cell transplantation and bone marrow stimulation with granulocyte macrophage-colony stimulating factor: Phase I/II clinical trial. Stem Cells. 25:2066–2073. 2007. View Article : Google Scholar
19.	Geffner LF, Santacruz P, Izurieta M, et al: Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies. Cell Transplant. 17:1277–1293. 2008. View Article : Google Scholar : PubMed/NCBI
20.	Kumar AA, Kumar SR, Narayanan R, et al: Autologous bone marrow derived mononuclear cell therapy for spinal cord injury: A phase I/II clinical safety and primary efficacy data. Exp Clin Transplant. 7:241–248. 2009.PubMed/NCBI
21.	Chernykh ER, Stupak VV, Muradov GM, et al: Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients. Bull Exp Biol Med. 143:543–547. 2007. View Article : Google Scholar : PubMed/NCBI
22.	Saito F, Nakatani T, Iwase M, et al: Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report. J Trauma. 64:53–59. 2008. View Article : Google Scholar : PubMed/NCBI
23.	Kishk NA, Gabr H, Hamdy S, et al: Case control series of intrathecal autologous bone marrow mesenchymal stem cell therapy for chronic spinal cord injury. Neurorehabil Neural Repair. 24:702–708. 2010. View Article : Google Scholar : PubMed/NCBI
24.	Sharp J, Frame J, Siegenthaler M, et al: Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury. Stem Cells. 28:152–163. 2010.PubMed/NCBI
25.	Hwang DH, Kim BG, Kim EJ, et al: Transplantation of human neural stem cells transduced with Olig2 transcription factor improves locomotor recovery and enhances myelination in the white matter of rat spinal cord following contusive injury. BMC Neurosci. 10:1172009. View Article : Google Scholar
26.	Keirstead HS, Nistor G, Bernal G, et al: Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 25:4694–4705. 2005. View Article : Google Scholar : PubMed/NCBI
27.	Vaquero J, Zurita M, Oya S and Santos M: Cell therapy using bone marrow stromal cells in chronic paraplegic rats: systemic or local administration? Neurosci Lett. 398:129–134. 2006. View Article : Google Scholar : PubMed/NCBI
28.	Akiyama Y, Radtke C and Kocsis JD: Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J Neurosci. 22:6623–6630. 2002.PubMed/NCBI
29.	Park HW, Lim MJ, Jung H, et al: Human mesenchymal stem cell-derived Schwann cell-like cells exhibit neurotrophic effects, via distinct growth factor production, in a model of spinal cord injury. Glia. 58:1118–1132. 2010. View Article : Google Scholar : PubMed/NCBI
30.	Weimann JM, Johansson CB, Trejo A and Blau HM: Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol. 5:959–966. 2003. View Article : Google Scholar : PubMed/NCBI