Needle-free injection of 5-aminolevulinic acid in photodynamic therapy for the treatment of condylomata acuminata

Li,Xiuli; Wang,Xiuxiu; Gu,Junying; Ma,Yue'e; Liu,Zhiyu; Shi,Yuling

doi:10.3892/etm.2013.1092

Needle-free injection of 5-aminolevulinic acid in photodynamic therapy for the treatment of condylomata acuminata

Authors:
- Xiuli Li
- Xiuxiu Wang
- Junying Gu
- Yue'e Ma
- Zhiyu Liu
- Yuling Shi
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Affiliations: Department of Dermatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
Published online on: April 29, 2013 https://doi.org/10.3892/etm.2013.1092
Pages: 236-240

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Abstract

The external application of 5-aminolevulinic acid (ALA) in photodynamic therapy (PDT) results in a shallow penetration depth in thick or extensive condylomata acuminata (CA) lesions, thus demonstrating a poor therapeutic effect for those patients. To compare the efficacy of needle-free injection with external application of ALA in PDT for the treatment of CA, 160 CA patients with thick or extensive warts received ALA-PDT by means of external application or needle-free injection of ALA, respectively. The complete response (CR) rate and recurrence rate in the two groups were analyzed. The CR rate after the first treatment in the needle‑free injection group (68.8%) was significantly higher compared with that in the external application group (52.5%; P=0.035). The recurrence rates in the needle-free injection group and external application group were 4.1 and 15.4%, respectively (P=0.022). The needle-free injection of ALA increases the therapeutic effect of PDT for CA patients with thick or extensive lesions. It shortens the treatment time and reduces the recurrence rate, and has great potential in the treatment of CA.

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