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Article

Celecoxib effectively inhibits the formation of joint adhesions

  • Authors:
    • Fengfeng Li
    • Bin He
    • Shen Liu
    • Cunyi Fan
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Sixth Affiliated People's Hospital of Shanghai Jiaotong University, Shanghai 200233, P.R. China, Department of Orthopedics, Second Affiliated Hospital of Nanjing Medical College, Nanjing 210011, P.R. China
  • Pages: 1507-1511
    |
    Published online on: October 9, 2013
       https://doi.org/10.3892/etm.2013.1336
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Abstract

The present study investigated the effectiveness of celecoxib in preventing the formation of joint adhesions. Rabbit models of joint adhesion were created and the rabbits in two treatment groups were orally administered celecoxib or ibuprofen (as a positive control) for 30 days. Rabbits in the control group did not receive any treatment. Following the 30‑day experimental period, the inhibitory effects of celecoxib and ibuprofen on the formation of joint adhesion were assessed using a number of methods, including the study of macroscopic appearance, histology and contracture angle. Thick fibrous adhesions developed in the knees of the rabbits in the control group. By contrast, few adhesions were observed in the two treatment groups, and those observed were soft, weak and easily stretched. Fewer adhesions were observed in the rabbits treated with celecoxib than in the rabbits in the other groups. The adhesion scores and contracture angles in the celecoxib (P<0.001) and ibuprofen (0.001
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Copy and paste a formatted citation
Spandidos Publications style
Li F, He B, Liu S and Fan C: Celecoxib effectively inhibits the formation of joint adhesions. Exp Ther Med 6: 1507-1511, 2013.
APA
Li, F., He, B., Liu, S., & Fan, C. (2013). Celecoxib effectively inhibits the formation of joint adhesions. Experimental and Therapeutic Medicine, 6, 1507-1511. https://doi.org/10.3892/etm.2013.1336
MLA
Li, F., He, B., Liu, S., Fan, C."Celecoxib effectively inhibits the formation of joint adhesions". Experimental and Therapeutic Medicine 6.6 (2013): 1507-1511.
Chicago
Li, F., He, B., Liu, S., Fan, C."Celecoxib effectively inhibits the formation of joint adhesions". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1507-1511. https://doi.org/10.3892/etm.2013.1336
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, He B, Liu S and Fan C: Celecoxib effectively inhibits the formation of joint adhesions. Exp Ther Med 6: 1507-1511, 2013.
APA
Li, F., He, B., Liu, S., & Fan, C. (2013). Celecoxib effectively inhibits the formation of joint adhesions. Experimental and Therapeutic Medicine, 6, 1507-1511. https://doi.org/10.3892/etm.2013.1336
MLA
Li, F., He, B., Liu, S., Fan, C."Celecoxib effectively inhibits the formation of joint adhesions". Experimental and Therapeutic Medicine 6.6 (2013): 1507-1511.
Chicago
Li, F., He, B., Liu, S., Fan, C."Celecoxib effectively inhibits the formation of joint adhesions". Experimental and Therapeutic Medicine 6, no. 6 (2013): 1507-1511. https://doi.org/10.3892/etm.2013.1336
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