Successful treatment of bronchial obstruction by flexible bronchoscopy and isoniazid: A case report

  • Authors:
    • Hengyi Chen
    • Xin Hong
    • Yong He
  • View Affiliations

  • Published online on: November 25, 2013     https://doi.org/10.3892/etm.2013.1423
  • Pages: 397-400
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Interventional bronchology techniques have been employed as an effective first‑line treatment in patients with tracheobronchial obstruction. However, recurrent stenosis produced by granulation tissue requires repeated procedures. Previous studies have indicated that isoniazid regulates collagen deposition and decreases collagen content. Thus, isoniazid has been successfully administered to patients with lesions who exhibited a delay in the healing process. A case of a left mainstem obstruction managed by interventional bronchology is described in the present study. Repeated bronchial stenosis was observed even following numerous treatment procedures, however, administration of isoniazid resulted in the inhibition of hypertrophic scar formation and prevention of repeated stenosis. The suppressive effect of isoniazid on granulation formation and further observations are reported. Few studies have been conducted with regard to the function of isoniazid in suppressing scar hyperplasia, therefore, the mechanism requires further investigation.
View Figures
View References

Related Articles

Journal Cover

2014-February
Volume 7 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Hong X and He Y: Successful treatment of bronchial obstruction by flexible bronchoscopy and isoniazid: A case report. Exp Ther Med 7: 397-400, 2014.
APA
Chen, H., Hong, X., & He, Y. (2014). Successful treatment of bronchial obstruction by flexible bronchoscopy and isoniazid: A case report. Experimental and Therapeutic Medicine, 7, 397-400. https://doi.org/10.3892/etm.2013.1423
MLA
Chen, H., Hong, X., He, Y."Successful treatment of bronchial obstruction by flexible bronchoscopy and isoniazid: A case report". Experimental and Therapeutic Medicine 7.2 (2014): 397-400.
Chicago
Chen, H., Hong, X., He, Y."Successful treatment of bronchial obstruction by flexible bronchoscopy and isoniazid: A case report". Experimental and Therapeutic Medicine 7, no. 2 (2014): 397-400. https://doi.org/10.3892/etm.2013.1423