Pre-treatment with EDTA-gallium prevents the formation of biofilms on surfaces

Zhu,Yuanyuan; Jin,Feng; Yang,Shuangwang; Li,Jingnong; Hu,Dan; Liao,Lianming

doi:10.3892/etm.2013.946

Pre-treatment with EDTA-gallium prevents the formation of biofilms on surfaces

Authors:
- Yuanyuan Zhu
- Feng Jin
- Shuangwang Yang
- Jingnong Li
- Dan Hu
- Lianming Liao
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Affiliations: Nanjing Junxie Hospital, Nanjing, Jiangsu, P.R. China, 476 Clinical Department, Fuzhou General Hospital, Xiamen University, Fuzhou, Fujian, P.R. China, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, P.R. China
Published online on: February 5, 2013 https://doi.org/10.3892/etm.2013.946
Pages: 1001-1004

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Abstract

Pseudomonas aeruginosa and Streptococcus pyogenes are leading causes of medical device-associated infections. The capacity to establish and maintain these infections is thought to be associated with the ability to form surface-attached biofilms. In the present study, gallium nitrate was used to coat PVC plates and biofilm formation on the plates by Pseudomonas aeruginosa and Streptococcus pyogenes was evaluated. The results demonstrated that coating the PVC surface with gallium reduced bacteria cell aggregation on the PVC surface and inhibited biofilm formation. These results suggest that surface pre-treatment with a gallium nitrate coating is a potential strategy for the prevention of infections associated with Pseudomonas aeruginosa or Streptococcus pyogenes on medical devices.

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