Treatment of mesial temporal lobe epilepsy with amygdalohippocampal stimulation: A case series and review of the literature

  • Authors:
    • Bao Min
    • Luan Guoming
    • Zhou Jian
  • View Affiliations

  • Published online on: February 20, 2013     https://doi.org/10.3892/etm.2013.968
  • Pages: 1264-1268
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Abstract

Deep brain stimulation (DBS) is being used with increasing frequency for the treatment of mesial temporal lobe epilepsy (MTLE). Here, we report two patients treated with amygdalohippocampal (AH)-DBS for drug-resistant temporal lobe epilepsy. Two patients with temporal lobe epilepsy were admitted to Beijing Sanbo Brain Hospital. The first patient was a 34-year-old male with a 31-year history of epileptic seizures. The second patient was a 27-year-old male with a 19-year history of drug-resistant epilepsy. The patients received a comprehensive presurgical workup and were considered unsuitable candidates for resective surgery. AH-DBS was recommended for the two patients. The last follow-up for patient 1 was 36 months after surgery and the final parameter settings were 3.6 mA, 450 µsec, 130 Hz and cycling with 60 sec on, 180 sec off. The last follow-up for patient 2 was 18 months after surgery and the final parameter settings were 2.6 mA, 450 µsec, 130 Hz and cycling with 60 sec on, 180 sec off. The patients experienced a seizure frequency reduction of 90 and 65%, respectively, with respect to the baseline. AH-DBS is a safe, micro-invasive alternative in patients with MTLE who are not candidates for resective surgery. It effectively reduces seizures without a negative effect on memory performance.
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April 2013
Volume 5 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Min B, Guoming L and Jian Z: Treatment of mesial temporal lobe epilepsy with amygdalohippocampal stimulation: A case series and review of the literature. Exp Ther Med 5: 1264-1268, 2013.
APA
Min, B., Guoming, L., & Jian, Z. (2013). Treatment of mesial temporal lobe epilepsy with amygdalohippocampal stimulation: A case series and review of the literature. Experimental and Therapeutic Medicine, 5, 1264-1268. https://doi.org/10.3892/etm.2013.968
MLA
Min, B., Guoming, L., Jian, Z."Treatment of mesial temporal lobe epilepsy with amygdalohippocampal stimulation: A case series and review of the literature". Experimental and Therapeutic Medicine 5.4 (2013): 1264-1268.
Chicago
Min, B., Guoming, L., Jian, Z."Treatment of mesial temporal lobe epilepsy with amygdalohippocampal stimulation: A case series and review of the literature". Experimental and Therapeutic Medicine 5, no. 4 (2013): 1264-1268. https://doi.org/10.3892/etm.2013.968