Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section

  • Authors:
    • Jianhua Gao
    • Ying Chen
    • Nong Liao
    • Wei Zhao
    • Weisen Zeng
    • Yingtao Li
    • Shaojing Wang
    • Feng Lu
  • View Affiliations

  • Published online on: March 5, 2014     https://doi.org/10.3892/etm.2014.1605
  • Pages: 1243-1246
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Abstract

The aim of the present study was to determine the relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section (CS). Blood samples from 260 female patients were collected one week following a CS for the detection of p53 gene polymorphisms using a molecular beacon‑coupled quantitative polymerase chain reaction technique. Patients had follow‑ups for 12‑18 months to observe the scar formation. From these observations, the relationship between the p53 codon‑72 polymorphisms and hypertrophic scar formation occurrence was investigated. Among the patients with the CCC/CCC genotype, nine patients had hypertrophic scars and 46 patients showed normal healing, which is a ratio of 0.19. However, the follow‑up investigations indicated that the presence of a homozygous or heterozygous C‑to‑G alteration at the codon‑72 site in gene p53 resulted in 13 patients with hypertrophic scars and 192 patients with normal healing, which is a ratio of 0.07. Therefore, these results indicate that patients with the CCC/CCC genotype had a higher risk of developing hypertrophic scars compared with that for patients with the CCC/CGC or CGC/CGC genotypes.
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May-2014
Volume 7 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Gao J, Chen Y, Liao N, Zhao W, Zeng W, Li Y, Wang S and Lu F: Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section. Exp Ther Med 7: 1243-1246, 2014.
APA
Gao, J., Chen, Y., Liao, N., Zhao, W., Zeng, W., Li, Y. ... Lu, F. (2014). Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section. Experimental and Therapeutic Medicine, 7, 1243-1246. https://doi.org/10.3892/etm.2014.1605
MLA
Gao, J., Chen, Y., Liao, N., Zhao, W., Zeng, W., Li, Y., Wang, S., Lu, F."Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section". Experimental and Therapeutic Medicine 7.5 (2014): 1243-1246.
Chicago
Gao, J., Chen, Y., Liao, N., Zhao, W., Zeng, W., Li, Y., Wang, S., Lu, F."Relationship between p53 gene codon‑72 polymorphisms and hypertrophic scar formation following caesarean section". Experimental and Therapeutic Medicine 7, no. 5 (2014): 1243-1246. https://doi.org/10.3892/etm.2014.1605