Salvia miltiorrhiza extracts protect against retinal injury in a rat glaucoma model

Zhu,Qi; Su,Guanfang; Nie,Lili; Wang,Chenguang; He,Yuxi; Liu,Xin

doi:10.3892/etm.2014.1632

Salvia miltiorrhiza extracts protect against retinal injury in a rat glaucoma model

Authors:
- Qi Zhu
- Guanfang Su
- Lili Nie
- Chenguang Wang
- Yuxi He
- Xin Liu
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Affiliations: Department of Ophthalmology, The Second Hospital of Jilin University, Changchun, Jilin 130041, P.R. China
Published online on: March 24, 2014 https://doi.org/10.3892/etm.2014.1632
Pages: 1513-1515

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Abstract

Glaucoma is a serious progressive degenerative disorder of the eye that leads to the continuous loss of retinal ganglion cells. Traditional Chinese medicine provides an important source for new drug screening and identification. The present study used Salvia miltiorrhiza (Danshen) extracts to examine the potential neuroprotective effects for the eye in a rat model of experimental glaucoma. The results of the study indicated that Salvia miltiorrhiza extracts were unable to prevent intraocular pressure increase in the laser‑induced glaucoma model, but the treatment did reduce cell loss during glaucoma progression. Therefore, the results provide the basis for the development of a novel therapeutic agent that exhibits neuroprotective effects against glaucoma. In the future, further studies are required to purify the extracts and determine the effective bioactive components of Salvia miltiorrhiza.

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