Effects of intensive insulin therapy combined with low molecular weight heparin anticoagulant therapy on severe pancreatitis

Du,Jun-Dong; Zheng,Xi; Huang,Zhi-Qiang; Cai,Shou-Wang; Tan,Jing-Wang; Li,Zhan‑Liang; Yao,Yong-Ming; Jiao,Hua-Bo; Yin,Hui-Nan; Zhu,Zi-Man

doi:10.3892/etm.2014.1694

Effects of intensive insulin therapy combined with low molecular weight heparin anticoagulant therapy on severe pancreatitis

Authors:
- Jun-Dong Du
- Xi Zheng
- Zhi-Qiang Huang
- Shou-Wang Cai
- Jing-Wang Tan
- Zhan‑Liang Li
- Yong-Ming Yao
- Hua-Bo Jiao
- Hui-Nan Yin
- Zi-Man Zhu
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Affiliations: Department of Heptapobiliary Surgery, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China, Division Three for Senior Officers, The First Affiliated Hospital to General Hospital of PLA, Beijing 100048, P.R. China, Department of Hepatobiliary Surgery, The General Hospital of PLA, Beijing 100853, P.R. China
Published online on: April 25, 2014 https://doi.org/10.3892/etm.2014.1694
Pages: 141-146

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Abstract

The current study explored the effects of intensive insulin therapy (IIT) combined with low molecular weight heparin (LMWH) anticoagulant therapy on severe acute pancreatitis (SAP). A total of 134 patients with SAP that received treatment between June 2008 and June 2012 were divided randomly into groups A (control; n=33), B (IIT; n=33), C (LMWH; n=34) and D (IIT + LMWH; n=34). Group A were treated routinely. Group B received continuous pumped insulin, as well as the routine treatment, to maintain the blood sugar level between 4.4 and 6.1 mmol/l. Group C received a subcutaneous injection of LMWH every 12 h in addition to the routine treatment. Group D received IIT + LMWH and the routine treatment. The white blood cell count, hemodiastase, serum albumin, arterial partial pressure of oxygen and prothrombin time were recorded prior to treatment and 1, 3, 5, 7 and 14 days after the initiation of treatment. The intestinal function recovery time, incidence rate of multiple organ failure (MOF), length of hospitalization and fatality rates were observed. IIT + LMWH noticeably increased the white blood cell count, hemodiastase level, serum albumin level and the arterial partial pressure of oxygen in the patients with SAP (P<0.05). It markedly shortened the intestinal recovery time and the length of stay and reduced the incidence rate of MOF, the surgery rate and the fatality rate (P<0.05). It did not aggravate the hemorrhagic tendency of SAP (P>0.05). IIT + LMWH had a noticeably improved clinical curative effect on SAP compared with that of the other treatments.

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