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Possible factors affecting thyroid dysfunction in hepatitis C virus‑infected untreated patients

  • Authors:
    • Xiao‑Rong Mao
    • Li‑Ting Zhang
    • Hong Chen
    • Ping Xiao
    • You‑Cheng Zhang

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  • Published online on: May 14, 2014     https://doi.org/10.3892/etm.2014.1709
  • Pages: 133-140
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Abstract

The present study investigated the association of thyroid dysfunction (TD) with the distribution of chronic hepatitis C virus (HCV) infection in untreated patients. A total of 1,012 cases of HCV‑infected patients were collected from different regions, of which 209 patients demonstrated a type of TD (chronic thyroiditis complicated with hyperthyroidism, chronic thyroiditis complicated with hypothyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, hyperthyroidism, hypothyroidism or chronic thyroiditis). The results showed the existence of geographical differences in the types of TD present with HCV infection. The female patients had a higher incidence of autoimmune‑related TD than the male patients. High levels of HCV RNA expression were most common in all HCV‑infected patients, regardless of the presence of TD. High and medium expression levels of HCV RNA were more prevalent in the patients with autoimmune‑related TD. Relative analysis of the HCV RNA levels showed that the pathogenesis of TD was not correlated with the HCV RNA expression levels; however, it may have been associated with autoimmunity. The HCV‑infected patients with TD were most commonly middle‑aged, whereas young adults were the largest group of patients with HCV and normal thyroid function. Among all HCV genotypes, type 1b was the most common HCV genotype and type 2 was the second most common. Types 3 and 6 were scarce in this study population. No associations were identified between HCV genotypes and thyroid disease. The data of liver function showed that HCV‑infected patients with TD had a higher liver dysfunction rate compared with that of the patients with normal thyroid function. Therefore, liver dysfunction may be associated with thyroid disease. This study supports the potential of individualized treatment for HCV‑infected patients.
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July-2014
Volume 8 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Mao XR, Zhang LT, Chen H, Xiao P and Zhang YC: Possible factors affecting thyroid dysfunction in hepatitis C virus‑infected untreated patients. Exp Ther Med 8: 133-140, 2014.
APA
Mao, X., Zhang, L., Chen, H., Xiao, P., & Zhang, Y. (2014). Possible factors affecting thyroid dysfunction in hepatitis C virus‑infected untreated patients. Experimental and Therapeutic Medicine, 8, 133-140. https://doi.org/10.3892/etm.2014.1709
MLA
Mao, X., Zhang, L., Chen, H., Xiao, P., Zhang, Y."Possible factors affecting thyroid dysfunction in hepatitis C virus‑infected untreated patients". Experimental and Therapeutic Medicine 8.1 (2014): 133-140.
Chicago
Mao, X., Zhang, L., Chen, H., Xiao, P., Zhang, Y."Possible factors affecting thyroid dysfunction in hepatitis C virus‑infected untreated patients". Experimental and Therapeutic Medicine 8, no. 1 (2014): 133-140. https://doi.org/10.3892/etm.2014.1709