miR‑155 mediates drug resistance in osteosarcoma cells via inducing autophagy

Chen,Lu; Jiang,Ke; Jiang,Hua; Wei,Peng

doi:10.3892/etm.2014.1752

miR‑155 mediates drug resistance in osteosarcoma cells via inducing autophagy

Authors:
- Lu Chen
- Ke Jiang
- Hua Jiang
- Peng Wei
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Affiliations: Orthopedics Department, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Orthopedics Department, Second People's Hospital of Chengdu, Chengdu, Sichuan 610017, P.R. China
Published online on: June 2, 2014 https://doi.org/10.3892/etm.2014.1752
Pages: 527-532

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Abstract

Frequent acquisition of drug resistance is often associated with the chemotherapy of malignant tumors, including osteosarcoma. A number of studies have demonstrated a critical role for autophagy in osteosarcoma development, therapy and drug resistance. However, the molecular mechanisms underlying the autophagy‑mediated chemotherapy resistance of osteosarcoma cells remain largely unknown. In the present study, we determined the autophagy and microRNA‑155 (miR‑155) expression induced by chemotherapeutic drugs in osteosarcoma cells. Then we determined the promotory role of miR-155 to the chemotherapy-induced autophagy. Our results demonstrated that microRNA‑155 (miR‑155) expression was highly induced during chemotherapy of osteosarcoma cells, and this was accompanied by upregulated autophagy. The increased miR‑155 expression levels upregulated anticancer drug‑induced autophagy in osteosarcoma cells and ameliorated the anticancer drug‑induced cell proliferation and viability decrease. Therefore, the results of the present study demonstrated that miR‑155 mediated drug‑resistance in osteosarcoma cells by inducing autophagy. The present study recognized a novel mechanism of chemoresistance in osteosarcoma cancers.

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