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Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin

  • Authors:
    • Yuxiang Dai
    • Hakuoh Konishi
    • Atsutoshi Takagi
    • Katsumi Miyauchi
    • Hiroyuki Daida

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  • Published online on: June 4, 2014     https://doi.org/10.3892/etm.2014.1755
  • Pages: 600-606
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Abstract

The present study compared short- and long‑term prognostic values of red blood cell distribution width (RDW) with those of hemoglobin (Hgb) among patients with acute congestive heart failure (CHF) in a cardiac care unit. The cross‑sectional study examined data from 521 patients with acute CHF who were admitted to a cardiac care unit and followed up for 24 months (median). Mean Hgb levels in patients who succumbed (DIH) or remained alive (AIH) were 11.0±1.8 and 11.8±2.6 g/l (P>0.05), respectively. Median values of RDW were 16.2% and 14.4%, respectively (P<0.0001). During the 24-month follow-up, mean levels of Hgb in groups with and without endpoints were 11.4±2.5 and 12.5±2.4 g/dl (P<0.0001), respectively. Median RDW values were 14.9 and 13.8%, respectively (P<0.0001). Logistic regression analysis showed that in-hospital mortality was significantly associated with RDW (P=0.044), New York Heart Association (NYHA) functional class IV (P=0.0037), estimated glomerular filtration rate (eGFR) (P=0.042) and C-reactive protein (P=0.0044), but not with Hgb (P=0.10). The multivariate Cox proportional hazard model selected RDW [hazard ratio (HR), 2.19; P<0.0001], left ventricular ejection fraction (HR 0.81, P=0.0016), age (10‑year increase; HR 1.19, P=0.0017) and NYHA functional classes III/IV (HR 1.52, P=0.0029) as independent predictors of long-term outcomes after adjustment, but not Hgb (HR 1.01, P=0.86). Higher RDW values in acute CHF patients at admission were associated with worse short- and long-term outcomes and RDW values were more prognostically relevant than Hgb levels.
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August-2014
Volume 8 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Dai Y, Konishi H, Takagi A, Miyauchi K and Daida H: Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin. Exp Ther Med 8: 600-606, 2014.
APA
Dai, Y., Konishi, H., Takagi, A., Miyauchi, K., & Daida, H. (2014). Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin. Experimental and Therapeutic Medicine, 8, 600-606. https://doi.org/10.3892/etm.2014.1755
MLA
Dai, Y., Konishi, H., Takagi, A., Miyauchi, K., Daida, H."Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin". Experimental and Therapeutic Medicine 8.2 (2014): 600-606.
Chicago
Dai, Y., Konishi, H., Takagi, A., Miyauchi, K., Daida, H."Red cell distribution width predicts short- and long-term outcomes of acute congestive heart failure more effectively than hemoglobin". Experimental and Therapeutic Medicine 8, no. 2 (2014): 600-606. https://doi.org/10.3892/etm.2014.1755