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Cryoablation combined with zoledronic acid in comparison with cryoablation and zoledronic acid alone in the treatment of painful bone metastases

  • Authors:
    • Fenqiang Li
    • Wenhui Wang
    • Li Li
    • Dongjun Su
    • Yaowen Chang
    • Gang Guo
    • Xuewen He
    • Baohua Li

  • View Affiliations

  • Published online on: June 13, 2014     https://doi.org/10.3892/etm.2014.1784
  • Pages: 539-544
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Abstract

This study aimed to examine the efficacy and safety of cryoablation, combined with zoledronic acid or alone, in the treatment of bone metastatic pain. A total of 84 patients were randomly divided into three groups: group A (cryoablation plus zoledronic acid), group B (cryoablation) and group C (zoledronic acid). In group A, the overall response [OR = complete response (CR) + partial response (PR)] was 85.7% (24/28), the CR was 35.7% (10/28) and the PR was 50.0% (14/28). In group B, the OR was 50.0% (14/28), the CR was 14.3% (4/28) and the PR was 35.7% (10/28). In group C, the OR was 67.9% (19/28), the CR was 21.4% (6/28) and the PR was 46.4% (13/28). The differences in OR, CR and PR among the three groups were statistically significant (P<0.05). The mean onset time of pain relief for the cryoablation combined with zoledronic acid treatment group was 1.96±2.26 days, for cryoablation treatment alone was 1.43±1.79 days and for zoledronic acid alone was 11.67±3.14 days; there were statistically significant differences among the three groups (P<0.05). The response duration was 146.68±1.89 days in group A, 71.60±2.94 days in group B and 112.99±1.37 days in group C; the differences among the three groups were statistically significant (P<0.01). In conclusion, cryoablation combined with zoledronic acid is an effective and safe therapeutic strategy for the treatment of bone metastatic pain.
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August-2014
Volume 8 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Li F, Wang W, Li L, Su D, Chang Y, Guo G, He X and Li B: Cryoablation combined with zoledronic acid in comparison with cryoablation and zoledronic acid alone in the treatment of painful bone metastases. Exp Ther Med 8: 539-544, 2014
APA
Li, F., Wang, W., Li, L., Su, D., Chang, Y., Guo, G. ... Li, B. (2014). Cryoablation combined with zoledronic acid in comparison with cryoablation and zoledronic acid alone in the treatment of painful bone metastases. Experimental and Therapeutic Medicine, 8, 539-544. https://doi.org/10.3892/etm.2014.1784
MLA
Li, F., Wang, W., Li, L., Su, D., Chang, Y., Guo, G., He, X., Li, B."Cryoablation combined with zoledronic acid in comparison with cryoablation and zoledronic acid alone in the treatment of painful bone metastases". Experimental and Therapeutic Medicine 8.2 (2014): 539-544.
Chicago
Li, F., Wang, W., Li, L., Su, D., Chang, Y., Guo, G., He, X., Li, B."Cryoablation combined with zoledronic acid in comparison with cryoablation and zoledronic acid alone in the treatment of painful bone metastases". Experimental and Therapeutic Medicine 8, no. 2 (2014): 539-544. https://doi.org/10.3892/etm.2014.1784