miR‑155 inhibitor reduces the proliferation and migration in osteosarcoma MG‑63 cells

  • Authors:
    • Huicheng Lv
    • Jun Guo
    • Siqin Li
    • Dianmin Jiang
  • View Affiliations

  • Published online on: September 1, 2014     https://doi.org/10.3892/etm.2014.1942
  • Pages: 1575-1580
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Abstract

As the most common malignant primary bone tumor in childhood, osteosarcoma (OS) maintains a high recurrence, despite the significant improvements in the overall survival rate of high‑grade OS patients during the recent decades. Therefore, a novel therapy strategy is required for OS treatment. Recently, various microRNAs (miRNAs or miRs) have been confirmed as deregulated in OS, and the miR‑155 dysregulation in OS has been discovered by the microarray analysis. In the present study, the regulation of miR‑155 on the OS cell proliferation, migration and invasion on the MG‑63 cells was explored in vitro. The miR‑155 mimics were found to promote cell proliferation, colony formation, migration and invasion significantly, compared to the control miRNA. An miR‑155 inhibitor was also used to evaluate whether miR‑155 served as a therapeutic target for OS. The results demonstrated that the miR‑155 inhibitor significantly reduced the proliferation, colony formation, migration and invasion of the MG‑63 OS cells. Thus, the study confirmed the oncogenic regulation on the OS progression of miR‑155, which could serve as a therapeutic target with an miR‑155 inhibitor.
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November-2014
Volume 8 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Lv H, Guo J, Li S and Jiang D: miR‑155 inhibitor reduces the proliferation and migration in osteosarcoma MG‑63 cells. Exp Ther Med 8: 1575-1580, 2014.
APA
Lv, H., Guo, J., Li, S., & Jiang, D. (2014). miR‑155 inhibitor reduces the proliferation and migration in osteosarcoma MG‑63 cells. Experimental and Therapeutic Medicine, 8, 1575-1580. https://doi.org/10.3892/etm.2014.1942
MLA
Lv, H., Guo, J., Li, S., Jiang, D."miR‑155 inhibitor reduces the proliferation and migration in osteosarcoma MG‑63 cells". Experimental and Therapeutic Medicine 8.5 (2014): 1575-1580.
Chicago
Lv, H., Guo, J., Li, S., Jiang, D."miR‑155 inhibitor reduces the proliferation and migration in osteosarcoma MG‑63 cells". Experimental and Therapeutic Medicine 8, no. 5 (2014): 1575-1580. https://doi.org/10.3892/etm.2014.1942