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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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November-2014 Volume 8 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome

  • Authors:
    • Ni Zhang
    • Ning Yang
    • Qilin Chen
    • Feng Qiu
    • Xingfu Li
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China, Center for Oncology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China, Department of Rheumatology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 1643-1647
    |
    Published online on: September 22, 2014
       https://doi.org/10.3892/etm.2014.1981
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Abstract

The aim of the present study was to investigate the expression and effect of progranulin (PGRN) in patients with primary Sjögren's syndrome (pSS). In total, 26 newly diagnosed pSS patients and 26 healthy subjects were enrolled in this study. The serum levels of PGRN and the inflammatory factor, interleukin‑6 (IL‑6), were detected using ELISA. In addition, the mRNA expression levels of these molecules were detected by quantitative polymerase chain reaction. The serum levels of PGRN and IL‑6 in the pSS patients increased significantly compared with the healthy controls (P<0.05). During the remission stages, the levels of PGRN and IL‑6 were comparable to those of the healthy controls. The serum level of PGRN in the pSS patients was shown to correlate with that of IL‑6 in the pre‑treatment and post‑treatment stages. PGRN was upregulated in the pSS patients, indicating a possible role of PGRN in the pathogenesis and development of pSS.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang N, Yang N, Chen Q, Qiu F and Li X: Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome. Exp Ther Med 8: 1643-1647, 2014.
APA
Zhang, N., Yang, N., Chen, Q., Qiu, F., & Li, X. (2014). Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome. Experimental and Therapeutic Medicine, 8, 1643-1647. https://doi.org/10.3892/etm.2014.1981
MLA
Zhang, N., Yang, N., Chen, Q., Qiu, F., Li, X."Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome". Experimental and Therapeutic Medicine 8.5 (2014): 1643-1647.
Chicago
Zhang, N., Yang, N., Chen, Q., Qiu, F., Li, X."Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome". Experimental and Therapeutic Medicine 8, no. 5 (2014): 1643-1647. https://doi.org/10.3892/etm.2014.1981
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang N, Yang N, Chen Q, Qiu F and Li X: Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome. Exp Ther Med 8: 1643-1647, 2014.
APA
Zhang, N., Yang, N., Chen, Q., Qiu, F., & Li, X. (2014). Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome. Experimental and Therapeutic Medicine, 8, 1643-1647. https://doi.org/10.3892/etm.2014.1981
MLA
Zhang, N., Yang, N., Chen, Q., Qiu, F., Li, X."Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome". Experimental and Therapeutic Medicine 8.5 (2014): 1643-1647.
Chicago
Zhang, N., Yang, N., Chen, Q., Qiu, F., Li, X."Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome". Experimental and Therapeutic Medicine 8, no. 5 (2014): 1643-1647. https://doi.org/10.3892/etm.2014.1981
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