Histological observation of goblet cells following topical rebamipide treatment of the human ocular surface: A case report
- Authors:
- Satoru Kase
- Toshiya Shinohara
- Manabu Kase
View Affiliations
Affiliations: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan, Department of Surgical Pathology, Teine Keijinkai Hospital, Sapporo 006-0811, Japan
- Published online on: December 5, 2014 https://doi.org/10.3892/etm.2014.2108
-
Pages:
456-458
Metrics: Total
Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
This article is mentioned in:
Abstract
The topical administration of rebamipide (Mucosta®), an antiulcer agent, clinically increases the mucin level of tear film. The aim of this study was to report the histological changes of goblet cells following the topical administration of rebamipide to a patient with nevus of the lacrimal caruncle. A 62-year-old male exhibited a pigmented nodule located in the lacrimal caruncle in the left eye. An excisional biopsy and subsequent surgical resection were conducted at the caruncle, prior to and three months after topical rebamipide administration. Histologically, a biopsy specimen revealed a pigmented nevus beneath the caruncle epithelium containing a few goblet cells [4 cells/high power field (HPF)]. A few nevus cells were present at the surgical margin. By contrast, the secondary resected specimen obtained three months after the initiation of topical rebamipide treatment revealed the epithelium and nevus, where numerous goblet cells were present (28 cells/HPF), and mucin-like substances were markedly secreted from the goblet cells. Topical rebamipide markedly increased the number of goblet cells and stimulated the secretion of mucin-like substances in the caruncular tissue of a human patient. These results suggest that topical rebamipide is useful in patients following surgery and/or biopsy to support tissue repair of the ocular surface.
View References
1
|
Le QH, Wang WT, Hong JX, Sun XH, Zheng TY,
Zhu WQ and Xu JJ: An in vivo confocal microscopy and impression
cytology analysis of goblet cells in patients with chemical burns.
Invest Ophthalmol Vis Sci. 51:1397–1400. 2010. View Article : Google Scholar : PubMed/NCBI
|
2
|
Kinoshita S, Awamura S, Oshiden K,
Nakamichi N, Suzuki H and Yokoi N: Rebamipide (OPC-12759) in the
treatment of dry eye: a randomized, double-masked, multicenter,
placebo-controlled phase II study. Ophthalmology. 119:2471–2478.
2012. View Article : Google Scholar : PubMed/NCBI
|
3
|
Urashima H, Takeji Y, Okamoto T, Fujisawa
S and Shinohara H: Rebamipide increases mucin-like substance
contents and periodic acid Schiff reagent-positive cells density in
normal rabbits. J Ocul Pharmacol Ther. 28:264–270. 2012. View Article : Google Scholar : PubMed/NCBI
|
4
|
Rios JD, Shatos M, Urashima H, Tran H and
Dartt DA: OPC-12759 increases proliferation of cultured rat
conjunctival goblet cells. Cornea. 25:573–581. 2006. View Article : Google Scholar : PubMed/NCBI
|
5
|
Ríos JD, Shatos MA, Urashima H and Dartt
DA: Effect of OPC-12759 on EGF receptor activation, p44/p42 MAPK
activity, and secretion in conjunctival goblet cells. Exp Eye Res.
86:629–636. 2008. View Article : Google Scholar : PubMed/NCBI
|
6
|
Ohguchi T, Kojima T, Ibrahim OM, Nagata T,
Shimizu T, Shirasawa T, Kawakita T, Satake Y, Tsubota K, Shimazaki
J and Ishida S: The effects of 2% rebamipide ophthalmic solution on
the tear functions and ocular surface of the superoxide dismutase-1
(sod1) knockout mice. Invest Ophthalmol Vis Sci. 54:7793–7802.
2013. View Article : Google Scholar : PubMed/NCBI
|
7
|
Kase S, Shinohara T and Kase M: Effect of
topical rebamipide on human conjunctival goblet cells. JAMA
Ophthalmol. 132:1021–1022. 2014. View Article : Google Scholar : PubMed/NCBI
|
8
|
Koh S, Inoue Y, Sugmimoto T, Maeda N and
Nishida K: Effect of rebamipide ophthalmic suspension on optical
quality in the short break-up time type of dry eye. Cornea.
32:1219–1223. 2013. View Article : Google Scholar : PubMed/NCBI
|
9
|
Kashima T, Akiyama H, Miura F and Kishi S:
Resolution of persistent corneal erosion after administration of
topical rebamipide. Clin Ophthalmol. 6:1403–1406. 2012. View Article : Google Scholar : PubMed/NCBI
|
10
|
Itakura H, Kashima T, Itakura M, Akiyama H
and Kishi S: Topical rebamipide improves lid wiper epitheliopathy.
Clin Ophthalmol. 7:2137–2141. 2013. View Article : Google Scholar : PubMed/NCBI
|