Pancreas β cell regeneration and type 1 diabetes (Review)

  • Authors:
    • Jinxiao Wu
    • Xiyan Yang
    • Bin Chen
    • Xiuping Xu
  • View Affiliations

  • Published online on: December 30, 2014     https://doi.org/10.3892/etm.2014.2163
  • Pages: 653-657
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Abstract

Diabetes mellitus, which may cause hyperglycemia and a number of complications, mostly results from a deficiency of β cell mass (type 1 diabetes) or a limitation of β cell function (type 2 diabetes). Currently, enhancing β cell regeneration and increasing cell proliferation have not only been described in experimental diabetes models, but have also been proven to improve outcomes for patients with diabetes. Therefore, understanding the mechanisms controlling the development and regeneration of β cells in the human pancreas may be helpful for the treatment of β cell-deficient disease. In this review, we first introduce the various cell types in the adult pancreas and thereby clarify their functions and origins. Then, the known mechanisms of β cell development and expansion in the normal human pancreas are described. The potential mechanisms of β cell regeneration, including β cell self‑replication, neogenesis from non‑β cell precursors and transdifferentiation from α cells, are discussed in the next part. Finally, the ability of the pancreas to regenerate mature β cells is explored in pathological conditions, including type 1 diabetes, chronic pancreatitis and persistent hyperinsulinemic hypoglycemia of infancy.
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March-2015
Volume 9 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wu J, Yang X, Chen B and Xu X: Pancreas β cell regeneration and type 1 diabetes (Review). Exp Ther Med 9: 653-657, 2015
APA
Wu, J., Yang, X., Chen, B., & Xu, X. (2015). Pancreas β cell regeneration and type 1 diabetes (Review). Experimental and Therapeutic Medicine, 9, 653-657. https://doi.org/10.3892/etm.2014.2163
MLA
Wu, J., Yang, X., Chen, B., Xu, X."Pancreas β cell regeneration and type 1 diabetes (Review)". Experimental and Therapeutic Medicine 9.3 (2015): 653-657.
Chicago
Wu, J., Yang, X., Chen, B., Xu, X."Pancreas β cell regeneration and type 1 diabetes (Review)". Experimental and Therapeutic Medicine 9, no. 3 (2015): 653-657. https://doi.org/10.3892/etm.2014.2163