Serum soluble CD40 is associated with liver injury in patients with chronic hepatitis B

  • Authors:
    • Hong-Hui Shen
    • Bing-Ke Bai
    • Ya-Qing Wang
    • Guang-De Zhou
    • Jun Hou
    • Yan Hu
    • Jing-Min Zhao
    • Bao-Sen Li
    • Hai-Li Huang
    • Pan-Yong Mao
  • View Affiliations

  • Published online on: January 14, 2015     https://doi.org/10.3892/etm.2015.2182
  • Pages: 999-1005
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Soluble cluster of differentiation 40 (sCD40) is proteolytically cleaved from membrane‑bound CD40 and binds to CD154, thereby inhibiting CD40‑CD154‑mediated immune responses. The aim of the present study was to clarify the role of sCD40 in chronic hepatitis B (CHB). The sCD40 levels in sera from 132 patients with CHB and 33 healthy individuals were retrospectively measured. sCD40 concentrations in patients with CHB were higher than those in healthy controls, and sCD40 levels correlated positively with serum levels of the liver dysfunction biomarkers alanine transaminase (ALT) and aspartate transaminase (AST). sCD40 concentrations increased with a rise in the severity of liver necroinflammation and fibrosis. Patients with >75% liver tissue staining positive for hepatitis B virus (HBV) antigen expression showed significantly lower sCD40 levels than those who stained negative for the HBV antigen. The area under the receiver operating characteristic curve of sCD40 was greater than that of ALT and AST; thus, sCD40 levels have a high diagnostic accuracy for detecting severe liver inflammation in patients with CHB, and could serve as an immunological marker of hepatic tissue injury.
View Figures
View References

Related Articles

Journal Cover

March-2015
Volume 9 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shen H, Bai B, Wang Y, Zhou G, Hou J, Hu Y, Zhao J, Li B, Huang H, Mao P, Mao P, et al: Serum soluble CD40 is associated with liver injury in patients with chronic hepatitis B. Exp Ther Med 9: 999-1005, 2015.
APA
Shen, H., Bai, B., Wang, Y., Zhou, G., Hou, J., Hu, Y. ... Mao, P. (2015). Serum soluble CD40 is associated with liver injury in patients with chronic hepatitis B. Experimental and Therapeutic Medicine, 9, 999-1005. https://doi.org/10.3892/etm.2015.2182
MLA
Shen, H., Bai, B., Wang, Y., Zhou, G., Hou, J., Hu, Y., Zhao, J., Li, B., Huang, H., Mao, P."Serum soluble CD40 is associated with liver injury in patients with chronic hepatitis B". Experimental and Therapeutic Medicine 9.3 (2015): 999-1005.
Chicago
Shen, H., Bai, B., Wang, Y., Zhou, G., Hou, J., Hu, Y., Zhao, J., Li, B., Huang, H., Mao, P."Serum soluble CD40 is associated with liver injury in patients with chronic hepatitis B". Experimental and Therapeutic Medicine 9, no. 3 (2015): 999-1005. https://doi.org/10.3892/etm.2015.2182