Open Access

Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro

Corrigendum in: /10.3892/etm.2023.12131

  • Authors:
    • Xiaoyi Liu
    • Jianxia Hu
    • Suyuan Sun
    • Funian Li
    • Weihong Cao
    • Yu Wang
    • Zhongliang Ma
    • Zhigang Yu
  • View Affiliations

  • Published online on: February 11, 2015     https://doi.org/10.3892/etm.2015.2286
  • Pages: 1192-1200
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Breast cancer is the most common malignancy among females throughout the world. Current treatments have unsatisfactory outcomes due to the dispersed nature of certain types of the disease. The development of a more effective therapy for breast cancer has long been one of the most elusive goals of cancer gene therapy. In the present study, human mesenchymal stem cells derived from umbilical cord (hUMSCs) genetically modified with interleukin 18 (IL‑18) gene were used to study the effect of hUMSCs/IL‑18 on the growth, migration and invasion of MCF‑7 and HCC1937 cells in vitro. The hUMSCs could be efficiently modified by lentiviral systems and stably expressed IL‑18 protein. hUMSCs/IL‑18, but not hUMSCs without the IL‑18 gene transduction, significantly suppressed the proliferation, migration and invasion of the MCF‑7 and HCC1937 cells. The mechanism of this proliferation suppression may have involved the induction of G1‑ to S‑phase arrest of the breast cancer cells by the hUMSCs/IL‑18. In conclusion, hUMSCs/IL‑18 can suppress the proliferation, migration and invasion of breast cancer cells in vitro and may provide an approach for a novel antitumor therapy in breast cancer.
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April-2015
Volume 9 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Liu X, Hu J, Sun S, Li F, Cao W, Wang Y, Ma Z and Yu Z: Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro Corrigendum in /10.3892/etm.2023.12131. Exp Ther Med 9: 1192-1200, 2015
APA
Liu, X., Hu, J., Sun, S., Li, F., Cao, W., Wang, Y. ... Yu, Z. (2015). Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro Corrigendum in /10.3892/etm.2023.12131. Experimental and Therapeutic Medicine, 9, 1192-1200. https://doi.org/10.3892/etm.2015.2286
MLA
Liu, X., Hu, J., Sun, S., Li, F., Cao, W., Wang, Y., Ma, Z., Yu, Z."Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro Corrigendum in /10.3892/etm.2023.12131". Experimental and Therapeutic Medicine 9.4 (2015): 1192-1200.
Chicago
Liu, X., Hu, J., Sun, S., Li, F., Cao, W., Wang, Y., Ma, Z., Yu, Z."Mesenchymal stem cells expressing interleukin-18 suppress breast cancer cells in vitro Corrigendum in /10.3892/etm.2023.12131". Experimental and Therapeutic Medicine 9, no. 4 (2015): 1192-1200. https://doi.org/10.3892/etm.2015.2286