Recurrent pulmonary synovial sarcoma effectively treated with amrubicin: A case report
- Authors:
- Published online on: February 24, 2015 https://doi.org/10.3892/etm.2015.2308
- Pages: 1947-1949
Abstract
Introduction
Although rare, primary synovial sarcoma is one of the most common variants of pulmonary sarcoma. Primary synovial sarcoma usually derive from soft tissue, most commonly in young individuals (1). Diagnosis requires a tissue sample in the form of a needle or open biopsy. Surgical resection is the standard primary treatment, and a 5-year distant metastasis-free survival of >60% may be achievable (2,3). However, recurrence remains a major problem and is responsible for treatment failures (4). Clinically, pulmonary synovial sarcoma may be characterized as an aggressive tumor; to the best of our knowledge, there has not been a single report of a long-term follow-up of a patient with pulmonary synovial sarcoma. The present study describes the case of a patient with recurrent pulmonary synovial sarcoma, who was effectively treated with amrubicin (AMR) monotherapy as a third-line chemotherapy following cisplatin and irinotecan and carboplatin and etoposide.
Case report
A 68-year-old female was admitted to hospital with a cough, dyspnea on exertion and a large, right-sided pleural effusion. The patient was a non-smoking housewife with no history of asbestos exposure. Thirty-five months prior to this admission, the patient underwent a left upper lobectomy and mediastinal lymph node dissection for a mass in the left upper lobe of the lung. The pathological diagnosis of the resected tumor was small cell lung cancer (SCLC) due to its weakly positive staining for synaptophysin and cluster of differentiation (CD) 56. Following the surgery, the patient received three courses of chemotherapy with cisplatin and irinotecan; however, local recurrence developed at the left mediastinum. The patient was therefore referred to the Mito Medical Center (Mito, Japan) to receive further chemotherapy. Chest computed tomography (CT) revealed a large mass in the left mediastinum; the mediastinum was shifted to the right and large, left-sided pericardial and pleural effusions were observed (Fig. 1). The patient then received two courses of chemotherapy with carboplatin and etoposide, but the response was evaluated as a progressive disease, despite severe myelosuppression (grade 4 thrombocytopenia in the National Cancer Institute-Common Toxicity Criteria), which required platelet transfusion. The patient additionally developed cardiac tamponade, which was successfully treated with tube drainage. Informed consent was obtained from the patients family.
As a third-line chemotherapy, to avoid severe myelosuppression, weekly AMR monotherapy was selected: Administration of 35 mg/m2 AMR three times during a four-week period (5). Myelotoxicity could then be evaluated prior to the next AMR administration. A partial response was achieved (Fig. 2) with no severe myelotoxicity. The patient received eight courses of the chemotherapy and was able to undertake ordinary daily life at home for 13 months from the initiation of the AMR chemotherapy. Local recurrence at the left mediastinum then developed and the patient succumbed of the disease, 50 months after the initial surgical resection of the tumor.
Due to the atypical clinical condition and unusual response to chemotherapy in this patient, the pathological examination was repeated. The resected tumor was composed of spindle cells with increased nuclear chromatin arranged uniformly (Fig. 3). Immunostaining with synaptophysin and CD56 revealed negative results. The tumor cells were positive for vimentin and B-cell lymphoma 2, but negative for cytokeratin AE1/AE3, α-smooth muscle actin, desmin, S-100, CD34, chromogranin A and synaptophysin. The SS18 split-signal was detected in fluorescence in situ hybridization analysis. From these results, the tumor was diagnosed as a monophasic synovial sarcoma.
Discussion
Pulmonary synovial sarcoma is a rare, aggressive primary tumor. The neoplasm was first described in 1995 by Zeren et al (6) as a distinctive pulmonary tumor of the lung, sharing histological and immunohistochemical characteristics with the monophasic synovial sarcoma of the soft tissue. Chest pain, dyspnea, cough and hemoptysis are the most common symptoms in patients with pulmonary synovial sarcoma (7); however, certain patients do not present with any symptoms (8). Radiologically, pulmonary synovial sarcoma appears mostly as well-circumscribed nodules of considerable size (9). In order to diagnose pulmonary synovial sarcoma, it is mandatory to exclude extrathoracic primary synovial sarcoma by whole-body survey. Detection of the t(X;18) chromosomal translocation can confirm the diagnosis (10,11). In the patient in the present case, no primary site other than the lung was found and positive split-signals from an SS18 probe were detected; a diagnosis of synovial sarcoma was thus confirmed. The patient was misdiagnosed with SCLC due to weakly positive staining for synaptophysin and CD56. SCLC is a tumor arising in a relatively large bronchus and predominantly occurs in patients with a smoking habit. In Japan, the majority of patients with SCLC have been males with a history of smoking (12). The present case was a female patient without a smoking habit. In addition, the patient had no history of exposure to carcinogenic chemicals such as asbestos. The poor response to platinum-containing chemotherapy was also unusual. The SCLC in this patient was therefore somewhat different from that usually observed. The histopathology of the resected tumor was re-evaluated and a correct diagnosis was achieved.
Surgical removal of the resectable tumor is the choice of treatment for pulmonary synovial sarcoma, and the prognosis of the disease is poor if the complete surgical resection cannot be performed. Bacha et al (13) reported that successful complete resection was significantly associated with increased survival, and that the size and grade of the tumors were not. As there have been no randomized control trials, the role of chemotherapy for unresectable and recurrent tumors remains unclear.
AMR is an anthracycline derivative with a structure similar to that of doxorubicine (14). Anthracyclines are widely used in the treatment of a variety of sarcomas (15). Although the cumulative dose-limiting cardiotoxicity is a major obstacle to its use (16), AMR has shown considerably less cardiotoxicity than doxorubicin in experimental models (17,18) and clinical trials (19,20). AMR has been demonstrated to be effective for previously treated SCLC (21,22). In the clinical course of the present case, the patient developed myelotoxicity, which required a platelet transfusion subsequent to the second course of the second-line chemotherapy with carboplatin and etoposide. AMR was therefore administered weekly (three times in four weeks at 35 mg/m2), taking the severe myelotoxicity of the second-line chemotherapy into consideration.
To the best of our knowledge, this is the first case of a patient with pulmonary synovial sarcoma to be effectively treated with AMR. Following AMR administration, the tumor exhibited a decrease in size on serial chest CT scan, and the survival benefit was obtained without any severe myelotoxicity and cardiotoxicity, although the patient had a history of cardiac tamponade. The present case could demonstrate a specific chemosensitivity of such a rare tumor.
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