Role of basophils in rheumatoid arthritis (Review)

  • Authors:
    • Pei Tang
    • Qiuhua Chen
    • Qiaofen Lan
    • Yanwen Chen
    • Haijuan Yang
    • Ning An
    • Haiyan Xiao
    • Huafeng Liu
    • Ping Wu
    • Tong Xie
    • Qingjun Pan
  • View Affiliations

  • Published online on: February 24, 2015     https://doi.org/10.3892/etm.2015.2312
  • Pages: 1567-1571
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Abstract

The T helper (Th)1/Th2 imbalance plays a crucial role in the development of rheumatoid arthritis (RA). It is well known that basophils can affect the Th1/Th2 balance by enhancing the Th2 response, while impairing the Th1 response, which is known to be involved in the development of a number of diseases. However, limited information is available with regard to the role of basophils in RA. Decreased levels of circulating basophils and a dominant Th1 response have been reported in adult patients with RA, while children with juvenile RA have been largely found to have increased levels of circulating basophils and a dominant Th2 response. Furthermore, the circulating basophils in the two conditions have an activated phenotype and are associated with disease activity. In addition, a longitudinal study found the Th2 response was dominant in the early stages of RA, while the Th1 response was dominant in long‑term chronic RA. These observations indicate that basophils may be involved in the development of RA by affecting the Th1/Th2 balance, particularly in the early stages of RA. Therefore, targeting basophils may be a novel therapeutic strategy for the treatment of RA; however, further investigation is required.
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May-2015
Volume 9 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Tang P, Chen Q, Lan Q, Chen Y, Yang H, An N, Xiao H, Liu H, Wu P, Xie T, Xie T, et al: Role of basophils in rheumatoid arthritis (Review). Exp Ther Med 9: 1567-1571, 2015
APA
Tang, P., Chen, Q., Lan, Q., Chen, Y., Yang, H., An, N. ... Pan, Q. (2015). Role of basophils in rheumatoid arthritis (Review). Experimental and Therapeutic Medicine, 9, 1567-1571. https://doi.org/10.3892/etm.2015.2312
MLA
Tang, P., Chen, Q., Lan, Q., Chen, Y., Yang, H., An, N., Xiao, H., Liu, H., Wu, P., Xie, T., Pan, Q."Role of basophils in rheumatoid arthritis (Review)". Experimental and Therapeutic Medicine 9.5 (2015): 1567-1571.
Chicago
Tang, P., Chen, Q., Lan, Q., Chen, Y., Yang, H., An, N., Xiao, H., Liu, H., Wu, P., Xie, T., Pan, Q."Role of basophils in rheumatoid arthritis (Review)". Experimental and Therapeutic Medicine 9, no. 5 (2015): 1567-1571. https://doi.org/10.3892/etm.2015.2312