Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation

  • Authors:
    • Yueying Liu
    • Luer Bao
    • Liying Xuan
    • Baohua Song
    • Lin Lin
    • Hao Han
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  • Published online on: April 23, 2015     https://doi.org/10.3892/etm.2015.2447
  • Pages: 263-268
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Abstract

Inflammatory response in the vasculature, including the overexpression of tumor necrosis factor (TNF)‑α and interleukin (IL)‑1β, has been demonstrated to increase the risk of thrombosis development. Chebulagic acid (CA) is a key chemical component in the traditional Mongolian anti‑thrombotic drug Garidi‑13, and has been suggested to exert anti‑inflammatory and anti‑infective effects. The present study aimed to evaluate the regulatory impact of CA on a number of biological processes, including lipopolysaccharide (LPS)‑induced inflammation, LPS‑promoted mitogen‑activated protein kinase (MAPK) activation and the expression of toll‑like receptor (TLR)4 in EA.hy926 human endothelial cells. The results indicated that CA significantly inhibited the LPS‑induced upregulation of TNF‑α and IL‑1β in a dose‑ and time‑dependent manner. Furthermore, LPS‑activated MAPK signaling was inhibited by CA treatment in the EA.hy926 cells. However, TLR4, which serves a key function in LPS‑induced inflammation as the receptor of LPS, was not regulated by the CA treatment. In summary, the results of the present study indicate that CA inhibits the LPS‑induced promotion of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation, which may contribute to the anti‑thrombotic effect of Garidi‑13.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu Y, Bao L, Xuan L, Song B, Lin L and Han H: Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation. Exp Ther Med 10: 263-268, 2015.
APA
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., & Han, H. (2015). Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation. Experimental and Therapeutic Medicine, 10, 263-268. https://doi.org/10.3892/etm.2015.2447
MLA
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., Han, H."Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation". Experimental and Therapeutic Medicine 10.1 (2015): 263-268.
Chicago
Liu, Y., Bao, L., Xuan, L., Song, B., Lin, L., Han, H."Chebulagic acid inhibits the LPS‑induced expression of TNF‑α and IL‑1β in endothelial cells by suppressing MAPK activation". Experimental and Therapeutic Medicine 10, no. 1 (2015): 263-268. https://doi.org/10.3892/etm.2015.2447