Correlation of high‑sensitivity C‑reactive protein and carotid plaques with coronary artery disease in elderly patients

Liang,Yanhong; Hou,Yuanping; Niu,Hongyu; Lu,Mei; Xue,Lei; Sun,Qianmei

doi:10.3892/etm.2015.2486

Correlation of high‑sensitivity C‑reactive protein and carotid plaques with coronary artery disease in elderly patients

Authors:
- Yanhong Liang
- Yuanping Hou
- Hongyu Niu
- Mei Lu
- Lei Xue
- Qianmei Sun
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Affiliations: Department of Geriatric Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China
Published online on: May 11, 2015 https://doi.org/10.3892/etm.2015.2486
Pages: 275-278

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Abstract

The aim of this study was to explore the correlation of high‑sensitivity C‑reactive protein (hs‑CRP) and carotid plaques with the severity of coronary artery disease (CAD). A total of 140 patients with angina who underwent coronary angiography were selected and divided into a single‑vessel disease group (n=11), double‑vessel disease group (n=18), multi‑vessel disease group (n=71) and control group (n=40). Color Doppler ultrasound was applied to measure the intima‑media thickness (IMT) of the common carotid artery (CCA) and carotid bifurcation, and to record the location and number of carotid plaques. The serum hs‑CRP level was also determined. Compared with the control and single‑vessel disease groups, the multi‑vessel disease group showed significantly higher IMT of the CCA (P<0.05). The serum hs‑CRP level was highest in the multi‑vessel disease group (P<0.01). The hs‑CRP level and carotid plaque characteristics were found to correlate closely with the severity of CAD. Therefore, they may be used to improve the prediction of CAD severity in elderly patients.

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1	Ross R: Atheroscherosis - an inflammatory disease. N Eng J Med. 340:115–126. 1999. View Article : Google Scholar
2	Kablak-Ziembicka A, Przewlocki T, Pieniazek P, et al: The role of carotid intima-media thickness assessment in cardiovascular risk evaluation in patients with polyvascular atherosclerosis. Atherosclerosis. 209:125–130. 2010. View Article : Google Scholar : PubMed/NCBI
3	Kabłak-Ziembicka A, Przewłocki T, Stępień E, et al: Relationship between carotid intima-media thickness, cytokines, atherosclerosis extent and a two-year cardiovascular risk in patients with arteriosclerosis. Kardiol Pol. 69:1024–1031. 2011.PubMed/NCBI
4	Rifai N and Ridker PM: High-sensitivity C-reactive protein: A novel and promising marker of coronary heart disease. Clin Chem. 47:403–411. 2001.PubMed/NCBI
5	Bokhari SA, Khan AA, Butt AK, et al: Non-surgical periodontal therapy reduces coronary heart disease risk markers: A randomized controlled trial. J Clin Periodontol. 39:1065–1074. 2012. View Article : Google Scholar : PubMed/NCBI
6	Cook NR: The case for C-reactive protein as a risk marker for coronary heart disease. Ann Intern Med. 152:406–407. 2010. View Article : Google Scholar : PubMed/NCBI
7	Toprak A, Kandavar R, Toprak D, et al: C-reactive protein is an independent predictor for carotid artery intima-media thickness progression in asymptomatic younger adults (from the Bogalusa Heart Study). BMC Cardiovasc Disord. 11:782011. View Article : Google Scholar : PubMed/NCBI
8	Molino-Lova R, Macchi C, Gori AM, et al: High sensitivity C-reactive protein predicts the development of new carotid artery plaques in older persons. Nutr Metab Cardiovasc Dis. 21:776–782. 2011. View Article : Google Scholar : PubMed/NCBI
9	Joshi MS, Tong L, Cook AC, et al: Increased myocardial prevalence of C-reactive protein in human coronary heart disease: Direct effects on microvessel density and endothelial cell survival. Cardiovasc Pathol. 21:428–435. 2012. View Article : Google Scholar : PubMed/NCBI
10	Ko YG, Le VC, Kim BH, et al: Correlations between coronary plaque tissue composition assessed by virtual histology and blood levels of biomarkers for coronary artery disease. Yonsei Med J. 53:508–516. 2012. View Article : Google Scholar : PubMed/NCBI
11	Schlager O, Exner M, Mlekusch W, et al: C-reactive protein predicts future cardiovascular events in patients with carotid stenosis. Stroke. 38:1263–1268. 2007. View Article : Google Scholar : PubMed/NCBI
12	Hannan EL, Samadashvili Z, Cozzens K, et al: Assessment of the new appropriate use criteria for diagnostic catheterization in the detection of coronary artery disease following noninvasive stress testing. Int J Cardiol. 170:371–375. 2014. View Article : Google Scholar : PubMed/NCBI
13	Guillard N, Lefèvre T, Spaulding C, et al: Coronary angiography by left radial approach: A bi-center prospective pilot study. Arch Mal Coeur Vaiss. 90:1349–1355. 1997.(In French). PubMed/NCBI
14	Zureik M, Bureau JM, Temmar M, et al: Echogenic carotid plaques are associated with aortic arterial stiffness in subjects with subclinical carotid atherosclerosis. Hypertension. 41:519–527. 2003. View Article : Google Scholar : PubMed/NCBI
15	Libby P, Ridker PM and Maseri A: Inflammation and atherosclerosis. Circulation. 105:1135–1143. 2002. View Article : Google Scholar : PubMed/NCBI
16	Blake GJ and Ridker PM: C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol. 41:(4 Suppl). 37S–42S. 2003. View Article : Google Scholar : PubMed/NCBI
17	Johnston SC, Zhang H, Messina LM, Lawton MT and Dean D: Chlamydia pneumoniae burden in carotid arteries is associated with upregulation of plaque interleukin-6 and elevated C-reactive protein in serum. Arterioscler Thromb Vasc Biol. 25:2648–2653. 2005. View Article : Google Scholar : PubMed/NCBI
18	Chambless LE, Folson AR, Cheqq LX, et al: Carotid wall thickness is predictive of incident clinical stroke: The Atherosclerosis Risk in Communities (ARIC) study. Am J Epidemiol. 151:478–487. 2000. View Article : Google Scholar : PubMed/NCBI
19	Heuten H, Goovaerts I, Ennekens G and Vrints C: Carotid artey intima-media thickness is associated with coronary artery disease. Acta Cardiol. 63:309–313. 2008. View Article : Google Scholar : PubMed/NCBI
20	Seo WK, Yong HS, Koh SB, et al: Correlation of coronary artery atherosclerosis with atherosclerosis of the intracranial cerebral artery and the extracranial carotid artery. Eur Neurol. 59:292–298. 2008. View Article : Google Scholar : PubMed/NCBI
21	Nguyen-Thanh HT and Benzaquen BS: Screening for subclinical coronary artery disease measuring carotid intima media thickness. Am J Cardiol. 104:1383–1388. 2009. View Article : Google Scholar : PubMed/NCBI
22	Zanchetti A, Hennig M, Hollweck R, et al: Baseline values but not treatment-induced changes in carotid intima-media thickness predict incident cardiovascular events in treated hypertensive patients: Findings in the European Lacidipine Study on Atherosclerosis (ELSA). Circulation. 120:1084–1090. 2009. View Article : Google Scholar : PubMed/NCBI