Kawasaki disease in children: Epidemiology, clinical symptoms and diagnostics of 231 cases in 10 years

Zhu,Hua; Yu,Shao‑Fei; Bai,Yu‑Xin; Liang,Yan‑Yan; Su,Xue‑Wen; Pan,Jing‑Ying

doi:10.3892/etm.2015.2487

Kawasaki disease in children: Epidemiology, clinical symptoms and diagnostics of 231 cases in 10 years

Authors:
- Hua Zhu
- Shao‑Fei Yu
- Yu‑Xin Bai
- Yan‑Yan Liang
- Xue‑Wen Su
- Jing‑Ying Pan
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Affiliations: Department of Pediatrics, People's Hospital of Inner Mongolia, Hohhot, Inner Mongolia Autonomous Region 010010, P.R. China
Published online on: May 11, 2015 https://doi.org/10.3892/etm.2015.2487
Pages: 357-361

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Abstract

The present study was a retrospective analysis of the dynamic changes and clinical characteristics of 231 cases of Kawasaki disease (KD) in pediatric patients admitted to the People's Hospital of Inner Mongolia between January 2003 and December 2012. A total of 37.23% of the cases occurred in the first 5 years, compared with 62.77% in the latter 5 years. The age distribution ranged from 3 months to 10 years, with a peak age of <1 year. The male‑to‑female ratio was 2.12:1, and the reoccurrence rate was 1.3%. Among the patient cohort, 7.8% were Mongolian children. The most common clinical symptom was fever (87.6%), while perianal skin peeling was the most rare (14.1%). With regard to the analyzed biomarkers, 90.4% of patients had abnormal platelet (PLT) counts; the next highest abnormality rates were associated with erythrocyte sedimentation rate (ESR) (74.46%) and white blood cell (WBC) counts (59.74%), followed by levels of C‑reactive protein (CRP) (57.58%), creatinine kinase‑MB (40.26%) and hemoglobin (Hb) (38.53%). In conclusion, the present study has found that approximately two‑thirds of cases of KD over a 10‑year period occurred in the latter 5 years. Changes in a number of experimental indicators, including PLT, ESR and WBC, could be used in the diagnosis of the condition and to reflect the success of the clinical treatment.

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