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Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy

  • Authors:
    • Xiao‑Bo Liu
    • Shu Pan
    • Xi‑Ge Yang
    • Zhi‑Wen Li
    • Qing‑Shan Sun
    • Zhuang Zhao
    • Hai‑Chun Ma
    • Cheng‑Ri Cui

  • View Affiliations

  • Published online on: May 18, 2015     https://doi.org/10.3892/etm.2015.2497
  • Pages: 181-186
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Abstract

In order to evaluate the effect of different doses of penehyclidine hydrochloride (penehyclidine) on heart rate (HR) and HR variability (HRV) in hysteroscopy, 180 patients (American Society of Anesthesiologists grade I‑II) were randomized equally to three groups: 0.5 mg penehyclidine and intravenous anesthesia (group I), 1.0 mg penehyclidine and intravenous anesthesia (group II) and saddle anesthesia combined with intravenous anesthesia (control group). HR and HRV, including total power (TP), low‑frequency power (LF), high‑frequency power (HF) and the LF to HF ratio (LF/HF), were recorded prior and subsequent to the induction of anesthesia (T0 and T1, respectively), following the start of surgery (T2) and following completion of surgery (T3). HR was lower at T2 than at T0 in the control patients, but no differences were observed in groups I and II. The HR at T2 was increased in group II compared with that in group I. TP in group II was significantly higher compared with that in group I at T2. At T1 and at T2, the LF and HF values were lower in group I than those in the controls. Patients in group II also had higher LF and HF at T2 than patients in group I. The HF was higher at T2 than that at T0 in the controls; however, the HF and LF did not change significantly within groups I and II. No significant differences were observed in the LF/HF ratio among the three groups. At a dose of 0.5 mg, penehyclidine stabilized HRV and did not alter the autonomic nervous modulation of HR. A penehyclidine dose of 1.0 mg may be superior to a dose of 0.5 mg in maintaining HR, but is less effective at balancing sympathetic and parasympathetic activity.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Liu XB, Pan S, Yang XG, Li ZW, Sun QS, Zhao Z, Ma HC and Cui CR: Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Exp Ther Med 10: 181-186, 2015
APA
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z. ... Cui, C. (2015). Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy. Experimental and Therapeutic Medicine, 10, 181-186. https://doi.org/10.3892/etm.2015.2497
MLA
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z., Ma, H., Cui, C."Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy". Experimental and Therapeutic Medicine 10.1 (2015): 181-186.
Chicago
Liu, X., Pan, S., Yang, X., Li, Z., Sun, Q., Zhao, Z., Ma, H., Cui, C."Effect of penehyclidine hydrochloride on heart rate variability in hysteroscopy". Experimental and Therapeutic Medicine 10, no. 1 (2015): 181-186. https://doi.org/10.3892/etm.2015.2497