Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications

Mu,Wei; Chen,Mingyou; Gong,Zushun; Zheng,Fei; Xing,Qichong

doi:10.3892/etm.2015.2540

Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications

Authors:
- Wei Mu
- Mingyou Chen
- Zushun Gong
- Fei Zheng
- Qichong Xing
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Affiliations: Department of Cardiology, Shandong Provincial Qianfoshan Hospital, Shandong University, Ji'nan, Shandong 250014, P.R. China
Published online on: June 3, 2015 https://doi.org/10.3892/etm.2015.2540
Pages: 423-428
Copyright: © Mu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to investigate the expression level of vascular cell adhesion molecule‑1 (VCAM‑1) in the aortic tissues of atherosclerotic patients and to explore the associated clinical implications. Full‑thickness aortic wall tissue samples were collected from atherosclerotic patients. Biochemical analysis was used for the detection of the serum levels of triglycerides (TG), total cholesterol (TC), low‑density lipoprotein cholesterol (LDL‑C), high‑density lipoprotein cholesterol (HDL‑C), lipoprotein (a) [Lp (a)], apolipoprotein (Apo) AI and Apo‑B. Coronary angiography and SYNTAX scoring were used to determine the extent and severity of the disease. Immunohistochemistry was employed for the detection of the VCAM‑1 protein expression levels in the arterial tissues. Significant differences were observed in the blood lipid levels between atherosclerotic patients and control subjects. Immunohistochemistry indicated that the aortic VCAM‑1 expression level in atherosclerotic patients was 0.23±0.06 optical density (OD) units, which was significantly higher than that in the control subjects (0.08±0.03 OD units). In the atherosclerotic patients, the aortic VCAM‑1 expression was positively correlated with the serum levels of TG (r=0.347), TC (r=0.469), LDL‑C (r=0.463), Lp (a) (r=0.507) and Apo‑B (r=0.384), while VCAM‑1 and HDL‑C were negatively correlated (r=‑0.319). Furthermore, a higher SYNTAX score was accompanied by a higher VCAM‑1 expression level (r=0.532), and an elevated aortic VCAM‑1 expression was associated with certain cardiovascular risk factors. In conclusion, aortic VCAM‑1 expression is associated with the severity of atherosclerosis and cardiovascular risk factors, indicating that VCAM‑1 plays a role in the pathogenesis of atherosclerosis.

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