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Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat‑fed ApoE‑knockout mice

  • Authors:
    • Mingxue Zhou
    • Hao Xu
    • Weihong Liu
    • Hongxu Liu

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  • Published online on: August 25, 2015     https://doi.org/10.3892/etm.2015.2711
  • Pages: 1265-1270

  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Abnormal collagen deposition, as well as collagen metabolism, plays a crucial role in the formation and progression of vulnerable atherosclerotic plaques (VAPs), which are susceptible to rupture. According to our previous findings, rosiglitazone, a thiazolidinedione, can promote the stability of atherosclerotic plaques in fat‑fed ApoE‑knockout mice; however, it is unknown whether it can modulate collagen deposition and metabolism in VAPs. The present study was designed to determine the effect of rosiglitazone on collagen deposition and metabolism in the plaques of fat‑fed ApoE‑knockout mice. Following 13 weeks of the high‑fat diet, the mice were randomized into three groups (10 mice/group) and intragastrically administered rosiglitazone, simvastatin and distilled water, respectively, for a further 13 weeks. The category of the collagen present in the plaques was evaluated using the picro‑Sirius red polarization method. Additionally, the protein expression of matrix metalloproteinase 9 (MMP‑9) and tissue inhibitor of metalloproteinase‑1 (TIMP‑1) in the plaques was determined using immunohistochemistry. The results showed that rosiglitazone reduced the lipid to collagen and type Ⅲ to type Ⅰ collagen ratios in the plaques, and these reductions were correlated with the reduction in the plaque MMP‑9 to TIMP‑1 ratio. These results suggest that rosiglitazone can modulate collagen deposition and metabolism and promote the stabilization of VAPs.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhou M, Xu H, Liu W and Liu H: Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat‑fed ApoE‑knockout mice. Exp Ther Med 10: 1265-1270, 2015.
APA
Zhou, M., Xu, H., Liu, W., & Liu, H. (2015). Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat‑fed ApoE‑knockout mice. Experimental and Therapeutic Medicine, 10, 1265-1270. https://doi.org/10.3892/etm.2015.2711
MLA
Zhou, M., Xu, H., Liu, W., Liu, H."Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat‑fed ApoE‑knockout mice". Experimental and Therapeutic Medicine 10.4 (2015): 1265-1270.
Chicago
Zhou, M., Xu, H., Liu, W., Liu, H."Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat‑fed ApoE‑knockout mice". Experimental and Therapeutic Medicine 10, no. 4 (2015): 1265-1270. https://doi.org/10.3892/etm.2015.2711