Biological and therapeutic activities, and anticancer properties of curcumin (Review)
- Authors:
- Donatella Perrone
- Fatima Ardito
- Giovanni Giannatempo
- Mario Dioguardi
- Giuseppe Troiano
- Lucio Lo Russo
- Alfredo De Lillo
- Luigi Laino
- Lorenzo Lo Muzio
-
Affiliations: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy - Published online on: September 17, 2015 https://doi.org/10.3892/etm.2015.2749
- Pages: 1615-1623
This article is mentioned in:
Abstract
Takahashi M, Ishiko T, Kamohara H, Hidaka H, Ikeda O, Ogawa M and Baba H: Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors. Mediators Inflamm. 2007:107672007.PubMed/NCBI | |
Jurenka JS: Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern Med Rev. 14:141–153. 2009.PubMed/NCBI | |
Wilken R, Veena MS, Wang MB and Srivatsan ES: Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol Cancer. 10:122011. View Article : Google Scholar : PubMed/NCBI | |
Miłobȩdzka J, Kostanecki S and Lampe V: Notes on Curcumins. Ber Deut Chem Ges. 43:2163–2170. 1910.(In German). | |
Sharma RA, Gescher AJ and Steward WP: Curcumin: The story so far. Eur J Cancer. 41:1955–1968. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V and Aggarwal BB: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis. 28:1765–1773. 2007. View Article : Google Scholar : PubMed/NCBI | |
Gupta SC, Kismali G and Aggarwal BB: Curcumin, a component of turmeric: From farm to pharmacy. Biofactors. 39:2–13. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kumar A, Ahuja A, Ali J and Baboota S: Conundrum and therapeutic potential of curcumin in drug delivery. Crit Rev Ther Drug Carrier Syst. 27:279–312. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ammon HP and Wahl MA: Pharmacology of Curcuma longa. Planta Med. 57:1–7. 1991. View Article : Google Scholar : PubMed/NCBI | |
Lev-Ari S, Strier L, Kazanov D, Elkayam O, Lichtenberg D, Caspi D and Arber N: Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford). 45:171–177. 2006. View Article : Google Scholar : PubMed/NCBI | |
Neerati P, Devde R and Gangi AK: Evaluation of the effect of curcumin capsules on glyburide therapy in patients with type-2 diabetes mellitus. Phytother Res. 28:1796–1800. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kim YS, Young MR, Bobe G, Colburn NH and Milner JA: Bioactive food components, inflammatory targets and cancer prevention. Cancer Prev Res (Phila). 2:200–208. 2009. View Article : Google Scholar : PubMed/NCBI | |
Bhullar KS, Jha A, Youssef D and Rupasinghe HP: Curcumin and its carbocyclic analogs: Structure-activity in relation to antioxidant and selected biological properties. Molecules. 18:5389–5404. 2013. View Article : Google Scholar : PubMed/NCBI | |
Somchit M, Changtam C, Kimseng R, Utaipan T, Lertcanawanichakul M, Suksamrarn A and Chunglok W: Demethoxycurcumin from Curcuma longa rhizome suppresses iNOS induction in an in vitro inflamed human intestinal mucosa model. Asian Pac J Cancer Prev. 15:1807–1810. 2014. View Article : Google Scholar : PubMed/NCBI | |
Li YB, Gao JL, Zhong ZF, Hoi PM, Lee SM and Wang YT: Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways. Pharmacol Rep. 65:700–709. 2013. View Article : Google Scholar : PubMed/NCBI | |
Food and Drug Administration (FDA): Food for Human Consumption; Part 182 - Substances generally recognized as safe. http://accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.10Accessed. 2011 | |
Aggarwal BB, Deb L and Prasad S: Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 20:185–205. 2014. View Article : Google Scholar : PubMed/NCBI | |
Masuda T, Hidaka K, Shinohara A, Maekawa T, Takeda Y and Yamaguchi H: Chemical studies on antioxidant mechanism of curcuminoid: Analysis of radical reaction products from curcumin. J Agric Food Chem. 47:71–77. 1999. View Article : Google Scholar : PubMed/NCBI | |
Wang YJ, Pan MH, Cheng AL, Lin LI, Ho YS, Hsieh CY and Lin JK: Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. 15:1867–1876. 1997. View Article : Google Scholar : PubMed/NCBI | |
Prasad K, Mantha SV, Kalra J and Lee P: Prevention of hypercholesterolemic atherosclerosis by garlic, an antixoidant. J Cardiovasc Pharmacol Ther. 2:309–320. 1997. View Article : Google Scholar : PubMed/NCBI | |
Surh YJ and Chun KS: Cancer chemopreventive effects of curcumin. Adv Exp Med Biol. 595:149–172. 2007. View Article : Google Scholar : PubMed/NCBI | |
Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK and Lee SS: Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-kappaB activation. Mutat Res. 480(481): 243–268. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hong J, Bose M, Ju J, Ryu JH, Chen X, Sang S, Lee MJ and Yang CS: Modulation of arachidonic acid metabolism by curcumin and related beta-diketone derivatives: Effects on cytosolic phospholipase A (2), cyclooxygenases and 5-lipoxygenase. Carcinogenesis. 25:1671–1679. 2004. View Article : Google Scholar : PubMed/NCBI | |
Zhang F, Altorki NK, Mestre JR, Subbaramaiah K and Dannenberg AJ: Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis. 20:445–451. 1999. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Zhang S, Geng JX and Hu XY: Curcumin inhibits human non-small cell lung cancer A549 cell proliferation through regulation of Bcl-2/Bax and cytochrome C. Asian Pac J Cancer Prev. 14:4599–4602. 2013. View Article : Google Scholar : PubMed/NCBI | |
Koeberle A, Northoff H and Werz O: Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. Mol Cancer Ther. 8:2348–2355. 2009. View Article : Google Scholar : PubMed/NCBI | |
Divya CS and Pillai MR: Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NF-kB and AP-1 translocation and modulation of apoptosis. Mol Carcinog. 45:320–332. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hess J, Angel P and Schorpp-Kistner M: AP-1 subunits: Quarrel and harmony among siblings. J Cell Sci. 117:5965–5973. 2004. View Article : Google Scholar : PubMed/NCBI | |
Panicker SR and Kartha CC: Curcumin attenuates glucose-induced monocyte chemoattractant protein-1 synthesis in aortic endothelial cells by modulating the nuclear factor-kappaB pathway. Pharmacology. 85:18–26. 2010. View Article : Google Scholar : PubMed/NCBI | |
Aggarwal BB, Sundaram C, Malani N and Ichikawa H: Curcumin: The Indian solid gold. Adv Exp Med Biol. 595:1–75. 2007. View Article : Google Scholar : PubMed/NCBI | |
Huang YF, Zhu XX, Ding ZS and Lv GY: Study on anti-angiogenesis effect of three curcumin pigments and expression of their relevant factors. Zhongguo Zhong Yao Za Zhi. 40:324–329. 2015.(In Chinese). PubMed/NCBI | |
Arbiser JL, Klauber N, Rohan R, van Leeuwen R, Huang MT, Fisher C, Flynn E and Byers HR: Curcumin is an in vivo inhibitor of angiogenesis. Mol Med. 4:376–383. 1998.PubMed/NCBI | |
Gururaj AE, Belakavadi M, Venkatesh DA, Marmé D and Salimath BP: Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun. 297:934–942. 2002. View Article : Google Scholar : PubMed/NCBI | |
Biswas S and Rahman I: Modulation of steroid activity in chronic inflammation: A novel anti-inflammatory role for curcumin. Mol Nutr Food Res. 52:987–994. 2008. View Article : Google Scholar : PubMed/NCBI | |
Yadav R, Jee B and Awasthi SK: Curcumin suppresses the production of pro-inflammatory cytokine interleukin-18 in lipopolysaccharide stimulated murine macrophage-like cells. Indian J Clin Biochem. 30:109–112. 2015. View Article : Google Scholar : PubMed/NCBI | |
Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM and Timmermann BN: Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 69:351–355. 2006. View Article : Google Scholar : PubMed/NCBI | |
Funk JL, Frye JB, Oyarzo JN, Kuscuoglu N, Wilson J, McCaffrey G, Stafford G, Chen G, Lantz RC, Jolad SD, et al: Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 54:3452–3464. 2006. View Article : Google Scholar : PubMed/NCBI | |
Nonose N, Pereira JA, Machado PR, Rodrigues MR, Sato DT and Martinez CA: Oral administration of curcumin (Curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats. Acta Cir Bras. 29:727–734. 2014. View Article : Google Scholar : PubMed/NCBI | |
Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A and Sahebkar A: Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytother Res. 28:1625–1631. 2014. View Article : Google Scholar : PubMed/NCBI | |
Srivastava R, Dikshit M, Srimal RC and Dhawan BN: Anti-thrombotic effect of curcumin. Trhomb Res. 40:413–417. 1985. View Article : Google Scholar | |
Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA and Gilani AH: Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 58:1167–1172. 1999. View Article : Google Scholar : PubMed/NCBI | |
Liu AC, Zhao LX and Lou HX: Curcumin alters the pharmacokinetics of warfarin and clopidogrel in Wistar rats but has no effect on anticoagulation or antiplatelet aggregation. Planta Med. 79:971–977. 2013. View Article : Google Scholar : PubMed/NCBI | |
Lala PK and Chakraborty C: Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol. 2:149–156. 2001. View Article : Google Scholar : PubMed/NCBI | |
de Rojas-Walker T, Tamir S, Ji H, Wishnok JS and Tannenbaum SR: Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA. Chem Res Toxicol. 8:473–477. 1995. View Article : Google Scholar : PubMed/NCBI | |
Graziewicz M, Wink DA and Laval F: Nitric oxide inhibits DNA ligase activity: Potential mechanisms for NO-mediated DNA damage. Carcinogenesis. 17:2501–2505. 1996. View Article : Google Scholar : PubMed/NCBI | |
Mourtas S, Lazar AN, Markoutsa E, Duyyckaerts C and Antimisiaris SG: Multifunctional nanoliposomes with curcumin-lipid derivative and brain targeting functionality with potential applications for Alzheimer disease. Eur J Med Chem. 80:175–183. 2014. View Article : Google Scholar : PubMed/NCBI | |
Fang L, Gou S, Liu X, Cao F and Cheng L: Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives. Bioorg Med Chem Lett. 24:40–43. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lazar AN, Mourtas S, Youssef I, Parizot C, Dauphin A, Delatour B, Antimisiaris SG and Duyckaerts C: Curcumin-conjugated nanoliposomes with high affinity for Aβ deposits: Possible applications to Alzheimer disease. Nanomedicine. 9:712–721. 2013. View Article : Google Scholar : PubMed/NCBI | |
Belkacemi A, Doggui S, Dao L and Ramassamy C: Challenges associated with curcumin therapy in Alzheimer disease. Expert Rev Mol Med. 13:e342011. View Article : Google Scholar : PubMed/NCBI | |
Motterlini R, Foresti R, Bassi R and Green CJ: Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 28:1303–1312. 2000. View Article : Google Scholar : PubMed/NCBI | |
Scapagnini G, Colombrita C, Amadio M, D'Agata V, Arcelli E, Sapienza M, Quattrone A and Calabrese V: Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid Redox Signal. 8:395–403. 2006. View Article : Google Scholar : PubMed/NCBI | |
Miao M, Guo L, Tian S and Wang T: Effects of curcumin on antioxidation in diabetic rats. Pak J Pharm Sci. 28(Suppl 1): 371–373. 2015.PubMed/NCBI | |
Liu Y, Wu YM, Yu Y, Cao CS, Zhang JH, Li K and Zhang PY: Curcumin and resveratrol in combination modulate drug-metabolizing enzymes as well as antioxidant indices during lung carcinogenesis in mice. Hum Exp Toxicol. 34:620–627. 2015. View Article : Google Scholar : PubMed/NCBI | |
Kamalakkannan N, Rukkumani R, Varma PS, Viswanathan P, Rajasekharan KN and Menon VP: Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol. 97:15–21. 2005. View Article : Google Scholar : PubMed/NCBI | |
Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG and Muriel P: Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 1770:989–996. 2007. View Article : Google Scholar : PubMed/NCBI | |
Sugiyama T, Nagata J, Yamagishi A, Endoh K, Saito M, Yamada K, Yamada S and Umegaki K: Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci. 78:2188–2193. 2006. View Article : Google Scholar : PubMed/NCBI | |
Maheshwari RK, Singh AK, Gaddipati J and Srimal RC: Multiple biological activities of curcumin: A short review. Life Sci. 78:2081–2087. 2006. View Article : Google Scholar : PubMed/NCBI | |
Yance DR Jr and Sagar SM: Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther. 5:9–29. 2006. View Article : Google Scholar : PubMed/NCBI | |
Karunagaran D, Rashmi R and Kumar TR: Induction of apoptosis by curcumin and its implications for cancer therapy. Curr Cancer Drug Targets. 5:117–129. 2005. View Article : Google Scholar : PubMed/NCBI | |
Helson L: Curcumin (diferuloylmethane) delivery methods: A review. Biofactors. 39:21–26. 2013. View Article : Google Scholar : PubMed/NCBI | |
Salvioli S, Sikora E, Cooper EL and Franceschi C: Curcumin in cell death processes: A challenge for CAM of age-related pathologies. Evid Based Complement Alternat Med. 4:181–190. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yang JY, Zhong X, Yum HW, Lee HJ, Kundu JK, Na HK and Surh YJ: Curcumin inhibits STAT3 signaling in the colon of dextran sulfate sodium-treated mice. J Cancer Prev. 18:186–191. 2013. View Article : Google Scholar : PubMed/NCBI | |
Vallianou NG, Evangelopoulos A, Schizas N and Kazazis C: Potential anticancer properties and mechanisms of action of curcumin. Anticancer Res. 35:645–651. 2015.PubMed/NCBI | |
Chuang SE, Cheng AL, Lin JK and Kuo ML: Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food Chem Toxicol. 38:991–995. 2000. View Article : Google Scholar : PubMed/NCBI | |
Busquets S, Carbó N, Almendro V, Quiles MT, López-Soriano FJ and Argilés JM: Curcumin, a natural product present in turmeric, decreases tumor growth but does not behave as an anticachectic compound in a rat model. Cancer Lett. 167:33–38. 2001. View Article : Google Scholar : PubMed/NCBI | |
Huang MT, Wang ZY, Georgiadis CA, Laskin JD and Conney AH: Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene. Carcinogenesis. 13:2183–2186. 1992. View Article : Google Scholar : PubMed/NCBI | |
Huang MT, Ma W, Lu YP, Chang RL, Fisher C, Manchand PS, Newmark HL and Conney AH: Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis. 16:2493–2497. 1995. View Article : Google Scholar : PubMed/NCBI | |
Huang MT, Ma W, Yen P, Xie JG, Han J, Frenkel K, Grunberger D and Conney AH: Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis. Carcinogenesis. 18:83–88. 1997. View Article : Google Scholar : PubMed/NCBI | |
Huang MT, Smart RC, Wong CQ and Conney AH: Inhibitory effect of curcumin, chlorogenic acid, caffeic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 48:5941–5946. 1988.PubMed/NCBI | |
Jiang AJ, Jiang G, Li LT and Zheng JN: Curcumin induces apoptosis through mitochondrial pathway and caspases activation in human melanoma cells. Mol Biol Rep. 42:267–275. 2015. View Article : Google Scholar : PubMed/NCBI | |
Li L, Braiteh FS and Kurzrock R: Liposome-encapsulated curcumin: In vitro and in vivo effects on proliferation, apoptosis, signaling and angiogenesis. Cancer. 104:1322–1331. 2005. View Article : Google Scholar : PubMed/NCBI | |
Bao B, Ali S, Banerjee S, Wang Z, Logna F, Azmi AS, Kong D, Ahmad A, Li Y, Padhye S and Sarkar FH: Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res. 72:335–345. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ali S, Ahmad A, Aboukameel A, Bao B, Padhye S, Philip PA and Sarkar FH: Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells. Cancer Lett. 319:173–181. 2012. View Article : Google Scholar : PubMed/NCBI | |
Dorai T, Cao YC, Dorai B, Buttyan R and Katz AE: Therapeutic potential of curcumin in human prostate cancer III. Curcumin inhibits proliferation, induces apoptosis and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate. 47:293–303. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hong JH, Ahn KS, Bae E, Jeon SS and Choi HY: The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis. 9:147–152. 2006. View Article : Google Scholar : PubMed/NCBI | |
Li M, Zhang Z, Hill DL, Wang H and Zhang R: Curcumin, a dietary component, has anticancer, chemosensitization and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res. 67:1988–1996. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yallapu MM, Dobberpuhl MR, Maher DM, Jaggi M and Chauhan SC: Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr Drug Metab. 13:120–128. 2012. View Article : Google Scholar : PubMed/NCBI | |
Menon LG, Kuttan R and Kuttan G: Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer letters. 95:221–225. 1995. View Article : Google Scholar : PubMed/NCBI | |
Cai YY, Lin WP, Li AP and Xu JY: Combined effects of curcumin and triptolide on an ovarian cancer cell line. Asian Pac J Cancer Prev. 14:4267–4271. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yang CL, Liu YY, Ma YG, Xue YX, Liu DG, Ren Y, Liu XB, Li Y and Li Z: Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One. 7:e379602012. View Article : Google Scholar : PubMed/NCBI | |
Tanaka T, Makita H, Ohnishi M, Hirose Y, Wang A, Mori H, Satoh K, Hara A and Ogawa H: Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: Comparison with the protective effect of beta-carotene. Cancer Res. 54:4653–4659. 1994.PubMed/NCBI | |
Azuine MA and Bhide SV: Adjuvant chemoprevention of experimental cancer: Catechin and dietary turmeric in forestomach and oral cancer models. J Ethnopharmacol. 44:211–217. 1994. View Article : Google Scholar : PubMed/NCBI | |
Tomren MA, Másson M, Loftsson T and Tønnesen HH: Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: Stability, activity and complexation with cyclodextrin. Int J Pharm. 338:27–34. 2007. View Article : Google Scholar : PubMed/NCBI | |
Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N and Lotan R: Differential inhibition of protein translation machinery by curcumin in normal, immortalized and malignant oral epithelial cells. Cancer Prev Res (Phila). 3:331–338. 2010. View Article : Google Scholar : PubMed/NCBI | |
Chang KW, Hung PS, Lin IY, Hou CP, Chen LK, Tsai YM and Lin SC: Curcumin upregulates insulin-like growth factor binding protein-5 (IGFBP-5) and C/EBPalpha during oral cancer suppression. Int J Cancer. 127:9–20. 2010. View Article : Google Scholar : PubMed/NCBI | |
LoTempio MM, Veena MS, Steele HL, Ramamurthy B, Ramalingam TS, Cohen AN, Chakrabarti R, Srivatsan ES and Wang MB: Curcumin suppresses growth of head and neck squamous cell carcinoma. Clin Cancer Res. 11:6994–7002. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB and Krishnan S: Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys. 75:534–542. 2009. View Article : Google Scholar : PubMed/NCBI | |
Siwak DR, Shishodia S, Aggarwal BB and Kurzrock R: Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of I kappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer. 104:879–890. 2005. View Article : Google Scholar : PubMed/NCBI | |
Crowell JA, Steele VE and Fay JR: Targeting the AKT protein kinase for cancer chemoprevention. Mol Cancer Ther. 6:2139–2148. 2007. View Article : Google Scholar : PubMed/NCBI | |
Vermorken JB, Mesia R, Rivera F, Remenar E, Kawecki A, Rottey S, Erfan J, Zabolotnyy D, Kienzer HR, Cupissol D, et al: Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 359:1116–1127. 2008. View Article : Google Scholar : PubMed/NCBI | |
Aravindan N, Madhusoodhanan R, Ahmad S, Johnson D and Herman TS: Curcumin inhibits NF-kappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol Ther. 7:569–576. 2008. View Article : Google Scholar : PubMed/NCBI | |
Bachmeier BE, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Höhneke C, Jochum M, Nerlich AG and Pfeffer U: Curcumin downregulates the inflammatory cytokines CXCL1 and −2 in breast cancer cells via NF-kappaB. Carcinogenesis. 29:779–789. 2008. View Article : Google Scholar : PubMed/NCBI | |
Marin YE, Wall BA, Wang S, Namkoong J, Martino JJ, Suh J, Lee HJ, Rabson AB, Yang CS, Chen S and Ryu JH: Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res. 17:274–283. 2007. View Article : Google Scholar : PubMed/NCBI | |
Tomita M, Kawakami H, Uchihara JN, Okudaira T, Masuda M, Takasu N, Matsuda T, Ohta T, Tanaka Y, Ohshiro K and Mori N: Curcumin (diferuloylmethane) inhibits constitutive active NF-kappaB, leading to suppression of cell growth of human T-cell leukemia virus type I-infected T-cell lines and primary adult T-cell leukemia cells. Int J Cancer. 118:765–772. 2006. View Article : Google Scholar : PubMed/NCBI | |
Wang D, Veena MS, Stevenson K, Tang C, Ho B, Suh JD, Duarte VM, Faull KF, Mehta K, Srivatsan ES and Wang MB: Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway. Clin Cancer Res. 14:6228–6236. 2008. View Article : Google Scholar : PubMed/NCBI | |
Khafif A, Lev-Ari S, Vexler A, Barnea I, Starr A, Karaush V, Haif S and Ben-Yosef R: Curcumin: A potential radio-enhancer in head and neck cancer. Laryngoscope. 119:2019–2026. 2009. View Article : Google Scholar : PubMed/NCBI | |
Jagetia GC: Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol. 595:301–320. 2007. View Article : Google Scholar : PubMed/NCBI | |
Yallapu MM, Maher DM, Sundram V, Bell MC, Jaggi M and Chauhan SC: Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res. 3:112010. View Article : Google Scholar : PubMed/NCBI | |
Abuzeid WM, Davis S, Tang AL, Saunders L, Brenner JC, Lin J, Fuchs JR, Light E, Bradford CR, Prince ME and Carey TE: Sensitization of head and neck cancer to cisplatin through the use of a novel curcumin analog. Arch Otolaryngol Head Neck Surg. 137:499–507. 2011. View Article : Google Scholar : PubMed/NCBI | |
Li N, Chen X, Liao J, Yang G, Wang S, Josephson Y, Han C, Chen J, Huang MT and Yang CS: Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis. 23:1307–1313. 2002. View Article : Google Scholar : PubMed/NCBI | |
Manoharan S, Balakrishnan S, Menon VP, Alias LM and Reena AR: Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis. Singapore Med J. 50:139–146. 2009.PubMed/NCBI | |
Clark CA, McEachern MD, Shah SH, Rong Y, Rong X, Smelley CL, Caldito GC, Abreo FW and Nathan CO: Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma. Cancer Prev Res (Phila). 3:1586–1595. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kumar B, Yadav A, Hideg K, Kuppusamy P, Teknos TN and Kumar P: A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancer. PloS One. 9:e932082014. View Article : Google Scholar : PubMed/NCBI | |
Rao CV, Simi B and Reddy BS: Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis. 14:2219–2225. 1993. View Article : Google Scholar : PubMed/NCBI | |
Hu A, Huang JJ, Jin XJ, Li JP, Tang YJ, Huang XF, Cui HJ, Xu WH and Sun GB: Curcumin suppresses invasiveness and vasculogenic mimicry of squamous cell carcinoma of the larynx through the inhibition of JAK-2/STAT-3 signaling pathway. Am J Cancer Res. 5:278–288. 2014.PubMed/NCBI |