Open Access

Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis

  • Authors:
    • Fan‑Rong Zhao
    • Jun‑Xiu Lu
    • Mei Jia
    • Ya‑Ling Yin
    • Heng-Tian Qi
    • Mo‑Li Zhu
    • Li‑Juan Ma
    • Le‑Le Qiu
    • Guang-Ming Wan
    • Guang‑Rui Wan
  • View Affiliations

  • Published online on: September 23, 2015     https://doi.org/10.3892/etm.2015.2774
  • Pages: 1627-1634
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of this study was to investigate the protective effects of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rabbits and to explore the underlying mechanisms in order to provide experimental evidence for the clinical application of XMJ. An intraperitoneal injection of vitamin D3, combined with a high‑fat diet and sacculus injury, was utilized to establish the AS rabbit model. Following the oral administration of lovastatin, Zhibituo and different dosages of XMJ, respectively, blood was drawn from each rabbit for the detection of blood rheological indicators, such as serum lipids. The pathological changes in the right common carotid artery were observed. Vascular function experiments and the expression detection of common carotid artery‑related proteins by immunohistochemistry were conducted. XMJ was observed to decrease the blood lipid levels of the AS rabbits; increase the concentration of high‑density lipoprotein and apolipoprotein A; decrease blood viscosity, erythrocyte sedimentation rate and hematocrit; elevate the levels of endothelial nitric oxide synthase (eNOS) and Na+/H+ exchanger 1 in vascular tissues and decrease the levels of angiotensin II receptor, type 1 (AT‑1) and endothelin‑1 (ET‑1). In conclusion, XMJ was shown to lower the blood lipid levels of the experimental AS rabbits, improve the abnormal changes in hemorheology, increase the eNOS content in the vascular tissue, decrease the AT‑1 and ET‑1 levels and increase the endothelium-dependent vasodilation reaction. XMJ therefore has an anti-AS effect.
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November-2015
Volume 10 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhao FR, Lu JX, Jia M, Yin YL, Qi H, Zhu ML, Ma LJ, Qiu LL, Wan G, Wan GR, Wan GR, et al: Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis. Exp Ther Med 10: 1627-1634, 2015
APA
Zhao, F., Lu, J., Jia, M., Yin, Y., Qi, H., Zhu, M. ... Wan, G. (2015). Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis. Experimental and Therapeutic Medicine, 10, 1627-1634. https://doi.org/10.3892/etm.2015.2774
MLA
Zhao, F., Lu, J., Jia, M., Yin, Y., Qi, H., Zhu, M., Ma, L., Qiu, L., Wan, G., Wan, G."Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis". Experimental and Therapeutic Medicine 10.5 (2015): 1627-1634.
Chicago
Zhao, F., Lu, J., Jia, M., Yin, Y., Qi, H., Zhu, M., Ma, L., Qiu, L., Wan, G., Wan, G."Effects and mechanism of Xin Mai Jia in a rabbit model of atherosclerosis". Experimental and Therapeutic Medicine 10, no. 5 (2015): 1627-1634. https://doi.org/10.3892/etm.2015.2774