Treatment of choroid metastasis from lung adenocarcinoma with bevacizumab-containing chemotherapy: A case report

Makabe,Kenichi; Kurishima,Koichi; Shiozawa,Toshihiro; Miyazaki,Kunihiko; Ohara,Gen; Kagohashi,Katsunori; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/etm.2015.2893

Treatment of choroid metastasis from lung adenocarcinoma with bevacizumab-containing chemotherapy: A case report

Authors:
- Kenichi Makabe
- Koichi Kurishima
- Toshihiro Shiozawa
- Kunihiko Miyazaki
- Gen Ohara
- Katsunori Kagohashi
- Hiroaki Satoh
- Nobuyuki Hizawa
View Affiliations

Affiliations: Division of Ophthalmology, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 310‑0015, Japan, Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
Published online on: November 25, 2015 https://doi.org/10.3892/etm.2015.2893
Pages: 239-242

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The occurrence of ocular metastasis from lung cancer is uncommon. The present study reports the case of a 69-year-old female patient with lung adenocarcinoma who was found to have a metastatic lesion in the left choroid at the time of presentation. As the patient was found to have a mutation in the epidermal growth factor receptor, treatment with gefitinib was administered; however, the response was evaluated as a progressive disease. Thereafter, the patient received chemotherapy with carboplatin, pemetrexed and bevacizumab. Radiological imaging revealed shrinkage of the primary lesion and choroidal metastasis, and the visual power of the left eye was also shown to improve. Therefore, the present case report demonstrated the efficacy and safety of systemic bevacizumab therapy in combination with a platinum doublet for the treatment of choroid metastasis, with morphological and functional improvements observed with regard to the choroidal metastatic tumor.

View Figures

View References

1	Small W Jr: Management of ocular metastasis. Cancer Control. 5:326–332. 1998.PubMed/NCBI
2	Shields CL, Shields JA, Gross NE, Schwartz GP and Lally SE: Survey of 520 eyes with uveal metastases. Ophthalmology. 104:1265–1276. 1997. View Article : Google Scholar : PubMed/NCBI
3	Soysal HG: Metastatic tumors of the uvea in 38 eyes. Can J Ophthalmol. 42:832–835. 2007. View Article : Google Scholar : PubMed/NCBI
4	Kreusel KM, Wiegel T, Stange M, Bornfeld N, Hinkelbein W and Foerster MH: Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol. 134:445–447. 2002. View Article : Google Scholar : PubMed/NCBI
5	Tsina EK, Lane AM, Zacks DN, Munzenrider JE, Collier JM and Gragoudas ES: Treatment of metastatic tumors of the choroid with proton beam irradiation. Ophthalmology. 112:337–343. 2005. View Article : Google Scholar : PubMed/NCBI
6	Bunn PA Jr and Thatcher N: Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Conclusion. Oncologist. 13(Suppl 1): 37–46. 2008. View Article : Google Scholar : PubMed/NCBI
7	Freedman MI and Folk JC: Metastatic tumors to the eye and orbit. Patient survival and clinical characteristics. Arch Ophthalmol. 105:1215–1219. 1987. View Article : Google Scholar : PubMed/NCBI
8	Kanthan GL, Jayamohan J, Yip D and Conway RM: Management of metastatic carcinoma of the uveal tract: an evidence-based analysis. Clin Experiment Ophthalmol. 35:553–565. 2007. View Article : Google Scholar : PubMed/NCBI
9	Battikh MH, Ben Yahia S, Ben Sayah MM, et al: Choroid metastases revealing pulmonary adenocarcinoma resolved with chemotherapy. Rev Pneumol Clin. 60:353–356. 2004.(In French). View Article : Google Scholar : PubMed/NCBI
10	Shields JA, Perez N, Shields CL, Foxman S and Foxman B: Simultaneous choroidal and brain metastasis as initial manifestations of lung cancer. Ophthalmic Surg Lasers. 33:323–325. 2002.PubMed/NCBI
11	George B, Wirostko WJ, Connor TB and Choong NW: Complete and durable response of choroid metastasis from non-small cell lung cancer with systemic bevacizumab and chemotherapy. J Thorac Oncol. 4:661–662. 2009. View Article : Google Scholar : PubMed/NCBI
12	Kim SW, Kim MJ, Huh K and Oh J: Complete regression of choroidal metastasis secondary to non-small-cell lung cancer with intravitreal bevacizumab and oral erlotinib combination therapy. Ophthalmologica. 223:411–413. 2009. View Article : Google Scholar : PubMed/NCBI
13	Inagaki E, Shinoda H, Uchida A, et al: Effect of intravitreal injection of bevacizumab for exudative retinal detachment secondary to metastatic choroidal tumor: Case report. Atarashii Ganka. 28:587–592. 2011.(In Japanese).
14	D'Antonio C, Viterbo A, Romiti A, Enrici MM, Lauro S and Marchetti P: Complete regression of a non-small cell lung cancer choroidal metastasis with intravitreal bevacizumab. J Thorac Oncol. 7:468–469. 2012. View Article : Google Scholar : PubMed/NCBI
15	Lai CL, Fan KS, Lee YH, Chen HC and Fan WH: Intravitreal administration of bevacizumab in the treatment of choroidal metastasis in a patient with erlotinib-failed pulmonary adenocarcinoma. Lung Cancer. 76:496–498. 2012. View Article : Google Scholar : PubMed/NCBI
16	Singh N, Kulkarni P, Aggarwal AN, et al: Choroidal metastasis as a presenting manifestation of lung cancer. A report of 3 cases and systematic review of the literature. Medicine (Baltimore). 91:179–194. 2012. View Article : Google Scholar : PubMed/NCBI
17	Amselem L, Cervera E, Díaz-Llopis M, et al: Intravitreal bevacizumab (Avastin) for choroidal metastasis secondary to breast carcinoma: Short-term follow-up. Eye (Lond). 21:566–567. 2007.PubMed/NCBI
18	Kuo IC, Haller JA, Maffrand R, Sambuelli RH and Reviglio VE: Regression of a subfoveal choroidal metastasis of colorectal carcinoma after intravitreous bevacizumab treatment. Arch Ophthalmol. 126:1311–1313. 2008. View Article : Google Scholar : PubMed/NCBI