Radiation‑induced anaplastic ependymoma mimicking a skull base meningioma: A case report
- Authors:
- Aldo Spallone
- Pasquale Marchione
- Mario Di Capua
- Daniele Belvisi
View Affiliations
Affiliations: Section of Neurosurgery, Department of Clinical Neurosciences, Neurological Centre of Latium, Rome I‑00178, Italy, Clinical Neurophysiology Unit, Neuromed Institute IRCCS, Pozzilli I‑86077, Italy
- Published online on: December 16, 2015 https://doi.org/10.3892/etm.2015.2945
-
Pages:
455-457
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Abstract
The present study describes the case of a 63‑year‑old woman presenting with headache, dizziness and vomiting due to a an ovoid mass in the left pre‑bulbar cistern, apparently arising from the lower clivus and the foramen magnum. The clinical history revealed the subtotal removal of a right cerebellar low‑grade glioma 15 years previously and subsequent conventional 60‑Gy radiotherapy. Notably, following gross total resection, histopathological examination showed microscopic features that resulted in a diagnosis of anaplastic ependymoma. The patient underwent surgery to remove the mass and post‑operative chemotherapy with temozolomide. A progressive improvement of neurological signs and symptoms was observed during the postoperative course. At the 6‑month follow‑up, the patient was free from clinical and radiological recurrence. The unusual features of this rare secondary brain tumor were the extrassial location in the posterior fossa, the unusual age‑associated location of the histological subtype and the fact that it closely mimicked a skull‑base meningioma.
View References
|
1
|
Ecemis GC, Atmaca A and Meydan D:
Radiation-associated secondary brain tumors after conventional
radiotherapy and radiosurgery. Expert Rev Neurother. 13:557–565.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Cahan WG and Woodard HQ: Sarcoma arising
in irradiated bone; report of 11 cases. Cancer. 1:3–29. 1948.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Waga S and Handa H: Radiation-induced
meningioma: With review of literature. Surg Neurol. 5:215–229.
1976.PubMed/NCBI
|
|
4
|
Schwartz TH, Kim S, Glick RS, Bagiella E,
Balmaceda C, Fetell MR, Stein BM, Sisti MB and Bruce JN:
Supratentorial ependymomas in adult patients. Neurosurgery.
44:721–731. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Mork SJ and Loken AC: A follow-up study of
101 cases. Cancer. 40:907–915. 1977. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Coulon RA and Till K: Intracranial
ependymomas in children: A review of 43 cases. Childs Brain.
3:154–164. 1977.PubMed/NCBI
|
|
7
|
Khoo HM, Kishima H, Kinoshita M, Goto Y,
Kagawa N, Hashimoto N, Maruno M and Yoshimine T: Radiation-induced
anaplastic ependymoma with a remarkable clinical response to
temozolomide, A case report. Br J Neurosurg. 27:259–261. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Salvati M, Frati A, Russo N, Caroli E,
Polli FM, Minniti G and Delfini R: Radiation-induced gliomas,
Report of 10 cases and review of the literature. Surg Neurol.
60:60–67. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Spallone A, Gagliardi FM and Vagnozzi R:
Intracranil meningiomas related to external cranial radiation. Surg
Neurol. 12:153–159. 1979.PubMed/NCBI
|
|
10
|
Umansky F, Shoshan Y, Rosenthal G,
Fraifeld S and Spektor S: Radiation-induced meningioma. Neurosurg
Focus. 24:E72008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Spallone A, Izzo C and Orlandi A: Post
traumatic glioma, Report of a case. Case Rep Oncol. 7:403–409.
2013.
|
|
12
|
Spallone A, Neroni M and Giuffrè R:
Multiple skull base meningioma Case report. Surg Neurol.
51:274–280. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Paulino AC, Mai WY, Chintagumpala M, Taher
A and Teh BS: Radiation-induced malignant gliomas, Is there a role
for reirradiation? Int J Radiat Oncol Biol Phys. 71:1381–1387.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Alexander MJ, DeSalles AA and Tomiyasu U:
Multiple radiation-induced intracranial lesions after treatment for
pituitary adenoma. Histopathology. J Neurosurg. 88:111–115. 1998.
View Article : Google Scholar : PubMed/NCBI
|
