Radiation‑induced anaplastic ependymoma mimicking a skull base meningioma: A case report
- Authors:
- Aldo Spallone
- Pasquale Marchione
- Mario Di Capua
- Daniele Belvisi
View Affiliations
Affiliations: Section of Neurosurgery, Department of Clinical Neurosciences, Neurological Centre of Latium, Rome I‑00178, Italy, Clinical Neurophysiology Unit, Neuromed Institute IRCCS, Pozzilli I‑86077, Italy
- Published online on: December 16, 2015 https://doi.org/10.3892/etm.2015.2945
-
Pages:
455-457
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Abstract
The present study describes the case of a 63‑year‑old woman presenting with headache, dizziness and vomiting due to a an ovoid mass in the left pre‑bulbar cistern, apparently arising from the lower clivus and the foramen magnum. The clinical history revealed the subtotal removal of a right cerebellar low‑grade glioma 15 years previously and subsequent conventional 60‑Gy radiotherapy. Notably, following gross total resection, histopathological examination showed microscopic features that resulted in a diagnosis of anaplastic ependymoma. The patient underwent surgery to remove the mass and post‑operative chemotherapy with temozolomide. A progressive improvement of neurological signs and symptoms was observed during the postoperative course. At the 6‑month follow‑up, the patient was free from clinical and radiological recurrence. The unusual features of this rare secondary brain tumor were the extrassial location in the posterior fossa, the unusual age‑associated location of the histological subtype and the fact that it closely mimicked a skull‑base meningioma.
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