Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury

  • Authors:
    • Wen‑Sheng Deng
    • Qing Xu
    • Ye Liu
    • Chun‑Hui Jiang
    • Hong Zhou
    • Lei Gu
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  • Published online on: March 15, 2016     https://doi.org/10.3892/etm.2016.3160
  • Pages: 1955-1960
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Abstract

The present study aimed to investigate the effects of melatonin (MT) on liver function and lipid peroxidation following hepatic ischemia-reperfusion injury (IRI). A total of 66 male Sprague-Dawley rats were randomly assigned into three groups: Normal control (N) group, ischemia‑reperfusion (IR) group and the MT‑treated group. A hepatic IRI model was developed by blocking the first porta hepatis, and subsequently restoring hepatic blood inflow after 35 min. Following reperfusion, changes in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were detected by a chemical method at various time points. In the MT group, the MDA levels were significantly reduced (P<0.05) at all time points, as compared with the IR group. Furthermore, SOD activity was significantly increased (P<0.05) in the MT group, as compared with the IR group at all time points; and the levels of GSH in the MT group were significantly higher (P<0.05) than those of the IR group at 2, 4, and 8 h post‑reperfusion. The levels of ALT, AST and LDH were significantly reduced in the MT group at each time point, as compared with that of the IR group (P<0.05). In conclusion, MT exhibits potent antioxidant properties that may create favorable conditions for the recovery of liver function following IRI.
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May-2016
Volume 11 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Deng WS, Xu Q, Liu Y, Jiang CH, Zhou H and Gu L: Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury. Exp Ther Med 11: 1955-1960, 2016
APA
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., & Gu, L. (2016). Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury. Experimental and Therapeutic Medicine, 11, 1955-1960. https://doi.org/10.3892/etm.2016.3160
MLA
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., Gu, L."Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury". Experimental and Therapeutic Medicine 11.5 (2016): 1955-1960.
Chicago
Deng, W., Xu, Q., Liu, Y., Jiang, C., Zhou, H., Gu, L."Effects of melatonin on liver function and lipid peroxidation in a rat model of hepatic ischemia/reperfusion injury". Experimental and Therapeutic Medicine 11, no. 5 (2016): 1955-1960. https://doi.org/10.3892/etm.2016.3160