Open Access

Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report

  • Authors:
    • Yang Luo
    • Li Zhang
    • Yu‑Jiao Sun
    • Hua Du
    • Gui‑Lan Yang
  • View Affiliations

  • Published online on: March 24, 2016     https://doi.org/10.3892/etm.2016.3183
  • Pages: 2254-2258
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Mycosis fungoides (MF), a low‑malignant lymphoproliferative disorder, is the most common type of cutaneous T‑cell lymphoma. The current study reported a case of syringotropic MF, a rare variant of MF, which presented with reactive B cell proliferation, lymphoid follicle formation, hair loss and lymphadenopathy. The clinical manifestations of the patient were MF‑like lumps. Immunohistochemical staining of AE1/AE3 showed that there were abundant infiltrated lymphocytes surrounding the syringocystadenoma. In addition, the direction of the lymphocyte arrangement was consistent with the meandering direction of syringocystadenoma. The patient did not respond to 1‑month narrowband (311‑nm) ultraviolet therapy; however, a good response was obtained subsequent to one cycle of chemotherapy with vincristine sulfate, etoposide, L‑asparaginase and prednisone acetate (know as the VELP regimen). After 7 days of VELP chemotherapy, the skin lesions were ameliorated, hair loss was improved and lymphadenopathy disappeared. No lymphadenopathy or new skin lesions were observed during 6 months of follow-up.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Luo Y, Zhang L, Sun YJ, Du H and Yang GL: Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report. Exp Ther Med 11: 2254-2258, 2016.
APA
Luo, Y., Zhang, L., Sun, Y., Du, H., & Yang, G. (2016). Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report. Experimental and Therapeutic Medicine, 11, 2254-2258. https://doi.org/10.3892/etm.2016.3183
MLA
Luo, Y., Zhang, L., Sun, Y., Du, H., Yang, G."Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report". Experimental and Therapeutic Medicine 11.6 (2016): 2254-2258.
Chicago
Luo, Y., Zhang, L., Sun, Y., Du, H., Yang, G."Syringotropic mycosis fungoides responding well to VELP chemotherapy: A case report". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2254-2258. https://doi.org/10.3892/etm.2016.3183