Open Access

Clinical effect of ticagrelor administered in acute coronary syndrome patients following percutaneous coronary intervention

  • Authors:
    • Yanjiao Lu
    • Yanshen Li
    • Rui Yao
    • Yapeng Li
    • Ling Li
    • Luosha Zhao
    • Yanzhou Zhang
  • View Affiliations

  • Published online on: April 4, 2016     https://doi.org/10.3892/etm.2016.3224
  • Pages: 2177-2184
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to retrospectively analyze the clinical effect and safety of ticagrelor administration in acute coronary syndrome (ACS) patients following percutaneous coronary intervention (PCI). In total, 203 patients were enrolled, who were confirmed with ACS between March 2013 and May 2013, and had successfully undergone PCI. The patients were randomly divided into two groups, including the clopidogrel (group A, n=108) and ticagrelor groups (group B, n=95). Patients in group A were treated with a 600 mg loading dose of clopidogrel followed by 75 mg/day clopidogrel plus 100 mg/day aspirin. Patients in group B received a 180 mg loading dose of ticagrelor followed by 90 mg ticagrelor twice daily plus 100 mg/day aspirin. Light transmission aggregometry was performed to measure the platelet aggregation rate prior to and following 4 weeks of anti‑platelet drug treatment. In addition, the rate of cardiovascular events and the adverse drug reactions were recorded within a 1‑year treatment period. Compared with the clopidogrel group, the rate of recurrent angina in the ticagrelor group was significantly lower (P=0.05). However, the rate of dyspnea in the ticagrelor group was significantly higher when compared with that in the clopidogrel group (P=0.03). After 4 weeks of treatment, the reduction in the platelet aggregation rate was significantly different between the two groups (P<0.05). Therefore, ticagrelor, which is a novel antiplatelet aggregation drug, may reduce the rate of the adverse cardiovascular events in ACS patients following PCI, but a higher incidence of side‑effects, such as dyspnea, may be observed.
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June-2016
Volume 11 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Lu Y, Li Y, Yao R, Li Y, Li L, Zhao L and Zhang Y: Clinical effect of ticagrelor administered in acute coronary syndrome patients following percutaneous coronary intervention. Exp Ther Med 11: 2177-2184, 2016
APA
Lu, Y., Li, Y., Yao, R., Li, Y., Li, L., Zhao, L., & Zhang, Y. (2016). Clinical effect of ticagrelor administered in acute coronary syndrome patients following percutaneous coronary intervention. Experimental and Therapeutic Medicine, 11, 2177-2184. https://doi.org/10.3892/etm.2016.3224
MLA
Lu, Y., Li, Y., Yao, R., Li, Y., Li, L., Zhao, L., Zhang, Y."Clinical effect of ticagrelor administered in acute coronary syndrome patients following percutaneous coronary intervention". Experimental and Therapeutic Medicine 11.6 (2016): 2177-2184.
Chicago
Lu, Y., Li, Y., Yao, R., Li, Y., Li, L., Zhao, L., Zhang, Y."Clinical effect of ticagrelor administered in acute coronary syndrome patients following percutaneous coronary intervention". Experimental and Therapeutic Medicine 11, no. 6 (2016): 2177-2184. https://doi.org/10.3892/etm.2016.3224