Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients

Wu,Yifen; Zhang,Ning; Wu,Yifu; Zheng,Yanping; You,Xiaoen; Cao,Zhuo; Xu,Yaqi

doi:10.3892/etm.2016.3362

Effects of dopamine, norepinephrine and dobutamine on gastric mucosal pH of septic shock patients

Authors:
- Yifen Wu
- Ning Zhang
- Yifu Wu
- Yanping Zheng
- Xiaoen You
- Zhuo Cao
- Yaqi Xu
View Affiliations

Affiliations: Department of Critical Care Medicine, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Jinhua Guangfu Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of Nursing, Zhejiang Jinhua Guangfu Hospital, Jinhua, Zhejiang 321000, P.R. China, Department of Burn and Plastic Surgery, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China, Department of Respiration, Lishui People's Hospital, Lishui, Zhejiang 323000, P.R. China
Published online on: May 18, 2016 https://doi.org/10.3892/etm.2016.3362
Pages: 975-978
Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The effect of different vasoactive drugs on the pH [intracellular pH (pHi)] of gastric mucosa in patients with septic shock was evaluated in the present study. According to the vasoactive drugs applied, 48 patients with septic shock were divided into 3 groups: A, B and C, with 16 cases each. Cases of group A were treated with dopamine, those of group B with norepinephrine while those of group C were treated with norepinephrine plus dobutamine. The changes of pH of gastric mucosa were observed before treatment (baseline) and 6, 12, 24 and 48 h after treatment, and the hemodynamic indicators were observed before treatment (baseline) and 6 h after administration. The gastric mucosal pH was not significantly different between two of the three groups before treatment (each at P>0.05). The gastric mucosal pH of group A did not change 6, 12, 24 and 48 h after treatment with drugs compared with the baseline (all at P>0.05), while the gastric mucosal pH in groups B and C were each statistically higher at the time points of 6, 12, 24 and 48 h after treatment with drugs compared with the respective baselines (all at P<0.05). Following treatment with drugs, the gastric mucosal pH of group C at all the time points of 6, 12, 24 and 48 h after treatment were significantly higher than those of groups A and B at the same time points after treatment, while there were some statistical differences between groups A and B at these time points (6, 12, 24 and 48 h after treatment; P<0.05). The hemodynamic indicators of the patients before treatment were not significantly different between two of the three groups (all at P>0.05). Compared with the baseline values, the mean arterial pressure and the cardiac index of each group after treatment were significantly increased, the pulmonary capillary wedge pressure and the central venous pressure of groups B and C significantly increased (all at P<0.05) and the heart rate of group A was significantly increased (P<0.05). In conclusion, the gastric mucosal pH of the septic shock patients was increased when treated with norepinephrine or with dobutamine. Additionally, the gastric mucosal pH was significantly higher when the patients were treated with dobutamine and norepinephrine in combination than with norepinephrine or dopamine alone. Dopamine, norepinephrine and dobutamine can improve the systemic hemodynamic conditions in patients with septic shock.

View Figures

View References

1	Liu W, Shan LP, Dong XS, Liu XW, Ma T and Liu Z: Effect of early fluid resuscitation on the lung in a rat model of lipopolysaccharide-induced septic shock. Eur Rev Med Pharmacol Sci. 17:161–169. 2013.PubMed/NCBI
2	Zangrillo A, Putzu A, Monaco F, et al: Levosimendan reduces mortality in patients with severe sepsis and septic shock: A meta-analysis of randomized trials. J Crit Care. May 29–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
3	Adamik B, Zielinski S, Smiechowicz J and Kübler A: Endotoxin Elimination in Patients with Septic Shock: An Observation Study. Arch Immunol Ther Exp (Warsz). Jun 21–2015.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI
4	Daviaud F, Grimaldi D, Dechartres A, Charpentier J, Geri G, Marin N, Chiche JD, Cariou A, Mira JP and Pène F: Timing and causes of death in septic shock. Ann Intensive Care. 5:582015. View Article : Google Scholar : PubMed/NCBI
5	Dell'Anna AM and Taccone FS: Early-goal directed therapy for septic shock: is it the end? Minerva Anestesiol. 81:1138–1143. 2015.PubMed/NCBI
6	Khan MS, Ishaq MK and Jones KR: Gas-Forming Pyogenic Liver Abscess with Septic Shock. Case Rep Crit Care. 2015:6328732015.PubMed/NCBI
7	Cabrera JL and Pinsky MR: Management of septic shock: a protocol-less approach. Crit Care. 19:2602015. View Article : Google Scholar : PubMed/NCBI
8	Yang Y, Qiu HB, Tan Y, et al: Effects of dobutamine in combination with norepinephrine and dopamine on the splanchnic perfusion in sheep with septic shock. Chin Emerg Med Crit Dis. 15:658–661. 2003.(In Chinese).
9	Haibo Q: Applied evaluation of vasoactive drugs for septic shock. Chin Med J (Engl). 92:10062002.
10	Tripanichkul W and Jaroensuppaperch EO: Ameliorating effects of curcumin on 6-OHDA-induced dopaminergic denervation, glial response, and SOD1 reduction in the striatum of hemiparkinsonian mice. Eur Rev Med Pharmacol Sci. 17:1360–1368. 2013.PubMed/NCBI
11	Testa A, Giannuzzi R, Sollazzo F, Petrongolo L, Bernardini L and Dain S: Psychiatric emergencies (part II): Psychiatric disorders coexisting with organic diseases. Eur Rev Med Pharmacol Sci. 17(Suppl 1): 65–85. 2013.PubMed/NCBI
12	Fenli S, Feng W, Ronghua Z and Huande L: Biochemical mechanism studies of venlafaxine by metabonomic method in rat model of depression. Eur Rev Med Pharmacol Sci. 17:41–48. 2013.PubMed/NCBI
13	Abdel-Salam OM, Salem NA, El-Shamarka ME, Hussein JS, Ahmed NA and El-Nagar ME: Studies on the effects of aspartame on memory and oxidative stress in brain of mice. Eur Rev Med Pharmacol Sci. 16:2092–2101. 2012.PubMed/NCBI
14	Ozcan S, Soydan A and Tamam L: Supersensitivity psychosis in a case with clozapine tolerance. Eur Rev Med Pharmacol Sci. 16(Suppl 4): 70–73. 2012.PubMed/NCBI
15	Brunetti M, Di Tizio L, Dezi S, Pozzi G, Grandinetti P and Martinotti G: Aripiprazole, alcohol and substance abuse: a review. Eur Rev Med Pharmacol Sci. 16:1346–1354. 2012.PubMed/NCBI
16	Jiang LH, Liang QY and Shi Y: Pure docosahexaenoic acid can improve depression behaviors and affect HPA axis in mice. Eur Rev Med Pharmacol Sci. 16:1765–1773. 2012.PubMed/NCBI
17	Nastro Siniscalchi E, Gabriele G and Cascone P: Palatal fistula resulting from cocaine abuse: a case report. Eur Rev Med Pharmacol Sci. 16:280–282. 2012.PubMed/NCBI
18	Schiller WR: The relationship between oxygen delivery and oxygen consumption during fluid resuscitation of burn-related shock. J Burn Care Rehabil. 21:391–393. 2000. View Article : Google Scholar : PubMed/NCBI
19	Xia Y and Xueming F: Application of gastric mucosal pH monitoring in the nursing care of ICU. J Nurs. 39:652004.
20	Aboul Ezz HS, Khadrawy YA, Ahmed NA, Radwan NM and El Bakry MM: The effect of pulsed electromagnetic radiation from mobile phone on the levels of monoamine neurotransmitters in four different areas of rat brain. Eur Rev Med Pharmacol Sci. 17:1782–1788. 2013.PubMed/NCBI
21	Fasano A, Ricciardi L, Lena F, Bentivoglio AR and Modugno N: Intrajejunal levodopa infusion in advanced Parkinson's disease: long-term effects on motor and non-motor symptoms and impact on patient's and caregiver's quality of life. Eur Rev Med Pharmacol Sci. 16:79–89. 2012.PubMed/NCBI
22	Holzer P and Painsipp E: Differential effects of clonidine, dopamine, dobutamine, and dopexamine on basal and acid-stimulated mucosal blood flow in the rat stomach. Crit Care Med. 29:335–343. 2001. View Article : Google Scholar : PubMed/NCBI
23	Brazaitis M, Eimantas N, Daniuseviciute L, Vitkauskiene A, Paulauskas H and Skurvydas A: Two strategies for the acute response to cold exposure but one strategy for the response to heat stress. Int J Hyperthermia. 31:325–335. 2015. View Article : Google Scholar : PubMed/NCBI
24	Butte NF, Brandt ML, Wong WW, Liu Y, Mehta NR, Wilson TA, Adolph AL, Puyau MR, Vohra FA, Shypailo RJ, et al: Energetic adaptations persist after bariatric surgery in severely obese adolescents. Obesity (Silver Spring). 23:591–601. 2015. View Article : Google Scholar : PubMed/NCBI
25	Shahrokhi N, Keshavarzi Z and Khaksari M: Ulcer healing activity of Mumijo aqueous extract against acetic acid induced gastric ulcer in rats. J Pharm Bioallied Sci. 7:56–59. 2015. View Article : Google Scholar : PubMed/NCBI
26	Singh P, Dutta SR and Guha D: Gastric mucosal protection by aegle marmelos against gastric mucosal damage: role of enterochromaffin cell and serotonin. Saudi J Gastroenterol. 21:35–42. 2015. View Article : Google Scholar : PubMed/NCBI
27	Dabiri Y, Fahimi F, Jamaati H and Hashemian SM: The comparison of extemporaneous preparations of omeprazole, pantoprazole oral suspension and intravenous pantoprazole on the gastric pH of critically ill-patients. Indian J Crit Care Med. 19:21–26. 2015. View Article : Google Scholar : PubMed/NCBI
28	Zhang X, Xuan W, Yin P, Wang L, Wu X and Wu Q: Gastric tonometry guided therapy in critical care patients: a systematic review and meta-analysis. Crit Care. 19:222015. View Article : Google Scholar : PubMed/NCBI
29	Gulec Suyen G, Isbil-Buyukcoskun N, Cam B and Ozluk K: Effects of centrally injected glucagon-like peptide-2 on gastric mucosal blood flow in rats: possible mechanisms. Peptides. 64:62–66. 2015. View Article : Google Scholar : PubMed/NCBI
30	Silva E, DeBacker D, Creteur J and Vincent JL: Effects of vasoactive drugs on gastric intramucosal pH. Crit Care Med. 26:1749–1758. 1998. View Article : Google Scholar : PubMed/NCBI
31	Yamaura K, Akiyoshi K, Irita K and Takahashi S: Effect of coronary artery bypass grafting with gastroepiploic artery on gastric intramucosal pH and systemic inflammation. J Cardiovasc Surg (Torino). 42:723–729. 2001.PubMed/NCBI
32	Ivatury RR, Simon RJ, Havriliak D, Garcia C, Greenbarg J and Stahl WM: Gastric mucosal pH and oxygen delivery and oxygen consumption indices in the assessment of adequacy of resuscitation after trauma: A prospective, randomized study. J Trauma. 39:128–134, 134–136. 1995. View Article : Google Scholar : PubMed/NCBI