Severe adverse reactions caused by omeprazole: A case report

  • Authors:
    • Meiling Yu
    • Jianghua Qian
    • Daohua Guo
    • Li Li
    • Xiaolin Liu
  • View Affiliations

  • Published online on: June 8, 2016     https://doi.org/10.3892/etm.2016.3444
  • Pages: 1103-1106
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Abstract

A 61-year-old female patient was admitted to hospital following development of a whole-body rash for 10 days, diarrhea for 7 days, and unconsciousness and oliguria for 1 day. The patient had developed stomach discomfort following the oral administration of non‑steroidal anti‑inflammatory drugs, the exact nature of which was unknown, for the treatment of arthritic pain for >1 month. The patient was then prescribed omeprazole enteric‑coated tablets (20 mg twice daily) for treatment of this symptom. However, the patient developed a whole‑body rash 7 days after administering omeprazole, 10 days prior to admission. This symptom was followed by severe diarrhea with nausea and vomiting after 10 days, then shock. The shock occurred after administering omeprazole for 16 days. The patient developed a whole body rash 7 days after administering omeprazole, then 3 days later (after administering omeprazole for 10 days) severe diarrhea with nausea and vomiting occurred. The shock remained until administering omeprazole on the 16th day, with severe diarrhea with nausea and vomiting occurring 6 days later. The patient's condition did not improve following treatment for allergies, low blood pressure and oliguria in the Intensive Care Unit (ICU) department at Suzhou Municipal Hospital. For further diagnosis and treatment, the patient was admitted to the ICU department of The First Affiliated Hospital of Bengbu Medical College and was given a fluid infusion, antibiotics and phlegm‑reducing treatment, a plasma infusion, blood filtration, and anti‑diarrheal and anti‑allergy treatment. The patient's vital signs were stable, with a normal temperature and hemogram results, and improved kidney function and deflorescence. Genetic screening revealed that the patient poorly metabolized omeprazole. Therefore, severe adverse reactions (allergic shock, rash and diarrhea) experienced by the patient were caused by the accumulation of omeprazole metabolites resulting from its slow metabolism in vivo.
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August-2016
Volume 12 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Yu M, Qian J, Guo D, Li L and Liu X: Severe adverse reactions caused by omeprazole: A case report. Exp Ther Med 12: 1103-1106, 2016.
APA
Yu, M., Qian, J., Guo, D., Li, L., & Liu, X. (2016). Severe adverse reactions caused by omeprazole: A case report. Experimental and Therapeutic Medicine, 12, 1103-1106. https://doi.org/10.3892/etm.2016.3444
MLA
Yu, M., Qian, J., Guo, D., Li, L., Liu, X."Severe adverse reactions caused by omeprazole: A case report". Experimental and Therapeutic Medicine 12.2 (2016): 1103-1106.
Chicago
Yu, M., Qian, J., Guo, D., Li, L., Liu, X."Severe adverse reactions caused by omeprazole: A case report". Experimental and Therapeutic Medicine 12, no. 2 (2016): 1103-1106. https://doi.org/10.3892/etm.2016.3444