Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy

  • Authors:
    • Yu‑Wen Zhong
    • Juan Wu
    • Hua‑Long Hu
    • Wei‑Xin Li
    • Yong Zhong
  • View Affiliations

  • Published online on: July 14, 2016     https://doi.org/10.3892/etm.2016.3526
  • Pages: 1908-1914
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Abstract

Clinical studies have indicated that early brain injury (EBI) following subarachnoid hemorrhage (SAH) is associated with fatal outcomes. Oxidative stress and brain edema are the characteristic pathological events in occurrence EBI following SAH. The present study aimed to examine the effect of 3,4‑dihydroxyphenylethanol (DOPET) against SAH‑induced EBI, and to demonstrate whether the effect is associated with its potent free radical scavenging property. SAH was induced in rats using an endovascular perforation technique, and 24 h later the rats displayed diminished neurological scores and brain edema. Furthermore, elevated malondialdehyde (an index of lipid peroxidation) and depleted levels of antioxidants were observed in the rat cerebral cortex tissue. Quantitative polymerase chain reaction analysis indicated the upregulated mRNA expression of the apoptotic markers caspase‑3 and ‑9 in the cerebral cortex. Furthermore, the protein expression levels of the proinflammatory cytokines tumor necrosis factor‑α, interleukin (IL)‑1β and IL‑6 were significantly upregulated in SAH‑induced rats. By constrast, treatment with DOPET significantly attenuated EBI by reducing brain edema, elevation of antioxidant status, inhibition of apoptosis and inflammation. In this context, DOPET may be a potent agent in the treatment of EBI following SAH, as a result of its free radical scavenging capacity.
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September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhong YW, Wu J, Hu HL, Li WX and Zhong Y: Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy. Exp Ther Med 12: 1908-1914, 2016.
APA
Zhong, Y., Wu, J., Hu, H., Li, W., & Zhong, Y. (2016). Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy. Experimental and Therapeutic Medicine, 12, 1908-1914. https://doi.org/10.3892/etm.2016.3526
MLA
Zhong, Y., Wu, J., Hu, H., Li, W., Zhong, Y."Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy". Experimental and Therapeutic Medicine 12.3 (2016): 1908-1914.
Chicago
Zhong, Y., Wu, J., Hu, H., Li, W., Zhong, Y."Protective effect 3,4-dihydroxyphenylethanol in subarachnoid hemorrhage provoked oxidative neuropathy". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1908-1914. https://doi.org/10.3892/etm.2016.3526