Open Access

Plasmalemma vesicle‑associated protein: A crucial component of vascular homeostasis (Review)

  • Authors:
    • Ling Guo
    • Hongyan Zhang
    • Yinglong Hou
    • Tianshu Wei
    • Ju Liu
  • View Affiliations

  • Published online on: July 27, 2016     https://doi.org/10.3892/etm.2016.3557
  • Pages: 1639-1644
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Endothelial subcellular structures, including caveolae, fenestrae and transendothelial channels, are crucial for regulating microvascular function. Plasmalemma vesicle‑associated protein (PLVAP) is an endothelial cell‑specific protein that forms the stomatal and fenestral diaphragms of blood vessels and regulates basal permeability, leukocyte migration and angiogenesis. Loss of PLVAP in mice leads to premature mortality due to disrupted homeostasis. Evidence from previous studies suggested that PLVAP is involved in cancer, traumatic spinal cord injury, acute ischemic brain disease, transplant glomerulopathy, Norrie disease and diabetic retinopathy. Specifically, PLVAP expression has been demonstrated to be upregulated in these diseases, accompanied by pro‑angiogenic or pro‑inflammatory responses. Therefore, PLVAP is considered a novel therapeutic target, in addition to an endothelial cell marker. The present review summarizes the structure and functions of PLVAP, and its roles in pathophysiological processes.
View Figures
View References

Related Articles

Journal Cover

September-2016
Volume 12 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Guo L, Zhang H, Hou Y, Wei T and Liu J: Plasmalemma vesicle‑associated protein: A crucial component of vascular homeostasis (Review). Exp Ther Med 12: 1639-1644, 2016.
APA
Guo, L., Zhang, H., Hou, Y., Wei, T., & Liu, J. (2016). Plasmalemma vesicle‑associated protein: A crucial component of vascular homeostasis (Review). Experimental and Therapeutic Medicine, 12, 1639-1644. https://doi.org/10.3892/etm.2016.3557
MLA
Guo, L., Zhang, H., Hou, Y., Wei, T., Liu, J."Plasmalemma vesicle‑associated protein: A crucial component of vascular homeostasis (Review)". Experimental and Therapeutic Medicine 12.3 (2016): 1639-1644.
Chicago
Guo, L., Zhang, H., Hou, Y., Wei, T., Liu, J."Plasmalemma vesicle‑associated protein: A crucial component of vascular homeostasis (Review)". Experimental and Therapeutic Medicine 12, no. 3 (2016): 1639-1644. https://doi.org/10.3892/etm.2016.3557