Mediastinal syndrome: A report of three cases

Zardi,Enrico Maria; Pipita,Maria Elena; Afeltra,Antonella

doi:10.3892/etm.2016.3596

Mediastinal syndrome: A report of three cases

Authors:
- Enrico Maria Zardi
- Maria Elena Pipita
- Antonella Afeltra
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Affiliations: Department of Clinical Medicine and Rheumatology, Campus Bio‑Medico University of Rome, I‑00128 Rome, Italy
Published online on: August 12, 2016 https://doi.org/10.3892/etm.2016.3596
Pages: 2237-2240

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Abstract

Mediastinal syndromes are a group of disorders involving the anatomical structures of the mediastinum. An increase in the incidence of this syndrome has been observed following the widespread use of diagnostic imaging. In the present study, three different cases of mediastinal syndrome, one of which was complicated by superior vena cava syndrome, are discussed. The treatment in the three cases was dependent on the etiology. While a patient with goiter experienced resolution of the symptoms following thyroidectomy, and a patient with lymphoma experienced beneficial effects following medical treatment, the patient with lymph node metastasis caused by a gastric tumor succumbed to the disease. In conclusion, the present case reports demonstrated that mediastinal syndrome is a life threatening condition whose prognosis depends on the underlying cause.

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1	Shahrzad M, Le TS, Silva M, Bankier AA and Eisenberg RL: Anterior mediastinal masses. AJR Am J Roentgenol. 203:W128–W138. 2014. View Article : Google Scholar : PubMed/NCBI
2	Petersdorf SH and Wood DE: Lymphoproliferative disorders presenting as mediastinal neoplasms. Semin Thorac Cardiovasc Surg. 12:290–300. 2000. View Article : Google Scholar : PubMed/NCBI
3	Collins LG, Haines C, Perkel R and Enck RE: Lung cancer: diagnosis and management. Am Fam Physician. 75:56–63. 2007.PubMed/NCBI
4	Van Houtte P, De Jager R, Lustman-Maréchal J and Kenis Y: Prognostic value of the superior vena cava syndrome as the presenting sign of small cell anaplastic carcinoma of the lung. Eur J Cancer. 16:1447–1450. 1980. View Article : Google Scholar : PubMed/NCBI
5	Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H and Jaffe ES: The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 117:5019–5032. 2011. View Article : Google Scholar : PubMed/NCBI
6	Kishi K, Sonomura T, Mitsuzane K, Nishida N, Yang RJ, Sato M, Yamada R, Shirai S and Kobayashi H: Self-expandable metallic stent therapy for superior vena cava syndrome: Clinical observations. Radiology. 189:531–535. 1993. View Article : Google Scholar : PubMed/NCBI
7	Andrade MA: A review of 128 cases of posterior mediastinal goiter. World J Surg. 1:789–797. 1977. View Article : Google Scholar : PubMed/NCBI
8	Xu J, Shen B, Li Y and Zhang T: Enormous goiter in posterior mediastinum: Report of 2 cases and literature review. J Formos Med Assoc. 108:337–343. 2009. View Article : Google Scholar : PubMed/NCBI
9	Strollo DC, Rosado-de-Christenson ML and Jett JR: Primary mediastinal tumors: Part II. Tumors of the middle and posterior mediastinum. Chest. 112:1344–1357. 1997. View Article : Google Scholar : PubMed/NCBI
10	Markman M: Diagnosis and management of superior vena cava syndrome. Cleve Clin J Med. 66:59–61. 1999. View Article : Google Scholar : PubMed/NCBI
11	Aroor AR, Prakasha SR, Seshadri S, S T and Raghuraj U: A study of clinical characteristics of mediastinal mass. J Clin Diagn Res. 8:77–80. 2014.PubMed/NCBI
12	Cheng S: Superior vena cava syndrome: A contemporary review of a historic disease. Cardiol Rev. 17:16–23. 2009. View Article : Google Scholar : PubMed/NCBI
13	Zhang K, Liu W, Li Y, Zhang K, Gao X and Wang J: Mediastinal small cell cancer associated with Lambert-Eaton myasthenic syndrome: A case report. Exp Ther Med. 10:117–120. 2015.PubMed/NCBI
14	Davis RD Jr, Oldham HN Jr and Sabiston DC Jr: Primary cysts and neoplasms of the mediastinum: Recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg. 44:229–237. 1987. View Article : Google Scholar : PubMed/NCBI