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Alien hand syndrome following corpus callosum infarction: A case report and review of the literature

  • Authors:
    • Xiaoyu Gao
    • Bing Li
    • Wenzheng Chu
    • Xuwen Sun
    • Chunjuan Sun
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Yantai Yuhuangding Hospital Affiliated to Qingdao Medical University, Yantai, Shandong 264000, P.R. China, Department of Radiology, Yantai Yuhuangding Hospital Affiliated to Qingdao Medical University, Yantai, Shandong 264000, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2129-2135
    |
    Published online on: August 22, 2016
       https://doi.org/10.3892/etm.2016.3608
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Abstract

Alien hand syndrome (AHS) is characterized by involuntary and autonomous activity of the affected limbs, and consists of the frontal, callosal and posterior AHS variants. The callosal subtype, resulting from damage to the corpus callosum, frequently features intermanual conflict. However, infarction of the corpus callosum is rare due to abundant blood supply. The present study reported a case of AHS (callosal subtype, in the right hand) caused by callosal infarction. Infarction of the left corpus callosum was confirmed with magnetic resonance imaging. In addition, magnetic resonance angiography and digital subtraction angiography examinations revealed multiple lesions in the feeding arteries. Subsequent to antiplatelet therapy for 2 weeks following admission, the patient gradually recovered. Furthermore, the current study reviewed 31 previously reported cases of AHS following callosal infarction in the literature.
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1 

Graff-Radford J, Rubin MN, Jones DT, Aksamit AJ, Ahlskog JE, Knopman DS, Petersen RC, Boeve BF and Josephs KA: The alien limb phenomenon. J Neurol. 260:1880–1888. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Jeeves MA, Simpson DA and Geffen G: Functional consequences of the transcallosal removal of intraventricular tumors. J Neurol Neurosurg Pshychiatry. 42:134–142. 1979. View Article : Google Scholar

3 

Huang Y and Jia JP: Corpus callosum hematoma secondary to cerebral venous malformation presenting as alien hand syndrome. Neurocase. 19:377–381. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Gibb WRG, Luther PJ and Marsden CD: Corticobasal degeneration. Brain. 112:1171–1192. 1989. View Article : Google Scholar : PubMed/NCBI

5 

Feinberg TE, Schindler RJ, Flanagan NG and Haber LD: Two alien hand syndromes. Neurology. 42:19–24. 1992. View Article : Google Scholar : PubMed/NCBI

6 

Kim HY, Kim JY, Kim GU, Han HJ and Shin DI: Alien hand syndrome after epilepsia partialis continua: FDG PET and MRI studies. Epilepsy Behav. 23:71–73. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Ball JA, Lantos PL, Jackson M, Marsden CD, Scadding JW and Rossor MN: Alien hand sign in association with Alzheimer's histopathology. J Neurol Neurosurg Psychiatry. 56:1020–1023. 1993. View Article : Google Scholar : PubMed/NCBI

8 

Barclay CL, Bergeron C and Lang AE: Arm levitation in progressive supranuclear palsy. Neurology. 52:879–882. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Rubin M, Graff-Radford J, Boeve B, Josephs KA and Aksamit AJ: The alien limb phenomenon and Creutzfeldt-Jakob disease. Parkinsonism Relat Disord. 18:842–846. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Marey-Lopez J, Rubio-Nazabal E, Alonso-Magdalena L and Lopez-Facal S: Posterior alien hand syndrome after a right thalamic infarct. J Neurol Neurosurg Psychiatry. 73:447–449. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Dolado AM, Castrillo C, Urra DG and de Seijas E Varela: Alien hand sign or alien hand syndrome? J Neurol Neurosurg Psychiatry. 59:100–101. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Pack BC, Stewart KJ, Diamond PT and Gale SD: Posterior-variant alien hand syndrome: Clinical features and response to rehabilitation. Disabil Rehabil. 24:817–818. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Pappalardo A, Ciancio MR, Reggio E and Patti F: Posterior alien hand syndrome: Case report and rehabilitative treatment. Neurorehabil Neural Repair. 18:176–181. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Pooyania S, Mohr S and Gray S: Alien hand syndrome: A case report and description to rehabilitation. Disabil Rehabil. 33:1715–1718. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Kato H, Iijima M, Hiroi A, Kubo M and Uchigata M: A case of alien hand syndrome after right posterior cerebral artery territory infarction. Rinsho Shinkeigaku. 43:487–490. 2003.PubMed/NCBI

16 

Geschwind DH, Iacoboni M, Mega MS, Zaidel DW, Cloughesy T and Zaidel E: Alien hand syndrome: Interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum. Neurology. 45:802–808. 1995. View Article : Google Scholar : PubMed/NCBI

17 

Shi YQ and Zhou XD: Pratical Neurology. 3rd. Shanghai Scientific and Technical Publishers; Shanghai: pp. 492004

18 

Folstein MF, Folstein SE and McHugh PR: Mini mental state. A practical method for grading the cognitive state of patients for clinicians. J Psychiatr Res. 12:189–198. 1975. View Article : Google Scholar : PubMed/NCBI

19 

Verleger R, Binkofski F, Friedrich M, Sedlmeier P and Kömpf D: Anarchic-hand syndrome: ERP reflections of lost control over the right hemisphere. Brain Cogn. 77:138–150. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Suwanwela NC and Leelacheavasit N: Isolated corpus callosal infarction secondary to pericallosal artery disease presenting as alien hand syndrome. J Neurol Neurosurg Psychiatry. 72:533–536. 2002.PubMed/NCBI

21 

Nicholas JJ, Wichner MH, Gorelick PB and Ramsey MM: Naturalization of the alien hand: Case report. Arch Phys Med Rehabil. 79:113–114. 1998. View Article : Google Scholar : PubMed/NCBI

22 

Muangpaisan W, Srisajjakul S and Chiewvit P: The alien hand syndrome: Report of a case and review of the literature. J Med Assoc Thai. 88:1447–1452. 2005.PubMed/NCBI

23 

Lin JH, Kwan SY and Wu D: Mixed alien hand syndrome coexisting with left-sided extinction secondary to a left corpus callosal lesion: A case report. Mov Disord. 22:248–251. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Yuan JL, Wang SK, Guo XJ and Hu WL: Acute infarct of the corpus callosum presenting as alien hand syndrome: Evidence of diffusion weighted imaging and magnetic resonance angiography. BMC Neurol. 11:1422011. View Article : Google Scholar : PubMed/NCBI

25 

Goldberg G and Bloom KK: The alien hand sign. Localization, lateralization and recovery. Am J Phys Med Rehabil. 69:228–238. 1990. View Article : Google Scholar : PubMed/NCBI

26 

Giroud M and Dumas R: Clinical and topographical range of callosal infarction: A clinical and radiological correlation study. J Neurol Neurosurg Psychiatry. 59:238–242. 1995. View Article : Google Scholar : PubMed/NCBI

27 

Chan JL and Ross ED: Alien hand syndrome: Influence of neglect on the clinical presentation of frontal and callosal variants. Cortex. 33:287–299. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Biran I, Giovannetti T, Buxbaum L and Chatterjee A: The alien hand syndrome: What makes the alien hand alien? Cogn Neuropsychol. 23:563–582. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Jang SH, Lee J, Yeo SS and Chang MC: Callosal disconnection syndrome after corpus callosum infarct: A diffusion tensor tractography study. J Stroke Cerebrovasc Dis. 22:e240–e244. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Nowak DA, Bösl K, Lüdemann-Podubecka J, Gdynia HJ and Ponfick M: Recovery and outcome of frontal alien hand syndrome after anterior cerebral artery stroke. J Neurol Sci. 338:203–206. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Tanaka Y, Iwasa H and Yoshida M: Diagonistic dyspraxia: Case report and movement-related potentials. Neurology. 40:657–661. 1990. View Article : Google Scholar : PubMed/NCBI

32 

Gottlieb D, Robb K and Day B: Mirror movements in the alien hand syndrome. Case report. Am J Phys Med Rehabil. 71:297–300. 1992. View Article : Google Scholar : PubMed/NCBI

33 

Doody RS and Jankovic J: The alien hand and related signs. J Neurol Neurosurg Psychiatry. 55:806–810. 1992. View Article : Google Scholar : PubMed/NCBI

34 

Trojano L, Crisci C, Lanzillo B, Elefante R and Caruso G: How many alien hand syndromes? Follow-up of a case. Neurology. 43:2710–2712. 1993. View Article : Google Scholar : PubMed/NCBI

35 

Chan JL, Chen RS and Ng KK: Leg manifestation in alien hand syndrome. J Formos Med Assoc. 95:342–346. 1996.PubMed/NCBI

36 

Ay H, Buonanno FS, Price BH, Le DA and Koroshetz WJ: Sensory alien hand syndrome: Case report and review of the literature. J Neurol Neurosurg Psychiatry. 65:366–369. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Ong Hai BG and Odderson IR: Involuntary masturbation as a manifestation of stroke-related alien hand syndrome. Am J Phys Med Rehabil. 79:395–398. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Bejot Y, Caillier M, Osseby GV, Didi R, Ben Salem D, Moreau T and Giroud M: Involuntary masturbation and hemiballismus after bilateral anterior cerebral artery infarction. Clin Neurol Neurosurg. 110:190–193. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Espinosa PS, Smith CD and Berger JR: Alien hand syndrome. Neurology. 67:e212006. View Article : Google Scholar : PubMed/NCBI

40 

Park YW, Kim CH, Kim MO, Jeong HJ and Jung HY: Alien hand syndrome in stroke - case report & neurophysiologic study. Ann Rehabil Med. 36:556–560. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Gazzaniga MS: Cerebral specialization and interhemispheric communication: Does the corpus callosum enable the human condition? Brain. 123:1293–1326. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Kahilogullari G, Comert A, Arslan M, Esmer AF, Tuccar E, Elhan A, Tubbs RS and Ugur HC: Callosal branches of the anterior cerebral artery: An anatomical report. Clin Anat. 21:383–388. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Kasow DL, Destian S, Braun C, Quintas JC, Kagtsu NJ and Johnson CE: Corpus callosum infarcts with atypical clinical and radiologic presentations. AJNR Am J Neuroradiol. 21:1876–1880. 2000.PubMed/NCBI

44 

Barbeau E, Joubert S and Poncet M: A single case-study of diagonistic dyspraxia. Brain Cogn. 54:215–217. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Papagno C and Marsile C: Transient left-sided alien hand with callosal and unilateral fronto-mesial damage: A case study. Neuropsychologia. 33:1703–1709. 1995. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao X, Li B, Chu W, Sun X and Sun C: Alien hand syndrome following corpus callosum infarction: A case report and review of the literature. Exp Ther Med 12: 2129-2135, 2016.
APA
Gao, X., Li, B., Chu, W., Sun, X., & Sun, C. (2016). Alien hand syndrome following corpus callosum infarction: A case report and review of the literature. Experimental and Therapeutic Medicine, 12, 2129-2135. https://doi.org/10.3892/etm.2016.3608
MLA
Gao, X., Li, B., Chu, W., Sun, X., Sun, C."Alien hand syndrome following corpus callosum infarction: A case report and review of the literature". Experimental and Therapeutic Medicine 12.4 (2016): 2129-2135.
Chicago
Gao, X., Li, B., Chu, W., Sun, X., Sun, C."Alien hand syndrome following corpus callosum infarction: A case report and review of the literature". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2129-2135. https://doi.org/10.3892/etm.2016.3608
Copy and paste a formatted citation
x
Spandidos Publications style
Gao X, Li B, Chu W, Sun X and Sun C: Alien hand syndrome following corpus callosum infarction: A case report and review of the literature. Exp Ther Med 12: 2129-2135, 2016.
APA
Gao, X., Li, B., Chu, W., Sun, X., & Sun, C. (2016). Alien hand syndrome following corpus callosum infarction: A case report and review of the literature. Experimental and Therapeutic Medicine, 12, 2129-2135. https://doi.org/10.3892/etm.2016.3608
MLA
Gao, X., Li, B., Chu, W., Sun, X., Sun, C."Alien hand syndrome following corpus callosum infarction: A case report and review of the literature". Experimental and Therapeutic Medicine 12.4 (2016): 2129-2135.
Chicago
Gao, X., Li, B., Chu, W., Sun, X., Sun, C."Alien hand syndrome following corpus callosum infarction: A case report and review of the literature". Experimental and Therapeutic Medicine 12, no. 4 (2016): 2129-2135. https://doi.org/10.3892/etm.2016.3608
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