Open Access

Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer

  • Authors:
    • Zongbin Xu
    • Pan Chi
    • Jie Pan
    • Songfei Shen
    • Yanwu Sun
    • Xiaojie Wang
    • Xingrong Lu
  • View Affiliations

  • Published online on: September 20, 2016     https://doi.org/10.3892/etm.2016.3723
  • Pages: 2855-2860
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has been reported that kallikrein 11 (KLK11) is crucially involved in the development and progression of various types of cancer. However, the molecular mechanisms that underlie the involvement of KLK11 in aberrant colorectal cancer (CRC) cell growth remain largely unclear. The aim of the present study was to investigate the role of KLK11 and the effects of KLK11 on oxaliplatin (L‑OHP) chemosensitivity by knocking down KLK11 in LOVO and HCT‑8 cells. Loss‑of‑function assays revealed KLK11 inhibition significantly inhibited growth and induced apoptosis of CRC cells in vitro. Notably, further experiments found that knockdown of KLK11 expression increased the L‑OHP chemosensitivity of CRC cells. KLK11 inhibition of increased L‑OHP‑induced apoptosis may be associated with activation of caspase‑3 cleavage and the apoptosis signaling pathway. The present results indicated that KLK11 may be an potential target of interest for future research into therapies for CRC.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xu Z, Chi P, Pan J, Shen S, Sun Y, Wang X and Lu X: Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer. Exp Ther Med 12: 2855-2860, 2016.
APA
Xu, Z., Chi, P., Pan, J., Shen, S., Sun, Y., Wang, X., & Lu, X. (2016). Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer. Experimental and Therapeutic Medicine, 12, 2855-2860. https://doi.org/10.3892/etm.2016.3723
MLA
Xu, Z., Chi, P., Pan, J., Shen, S., Sun, Y., Wang, X., Lu, X."Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer". Experimental and Therapeutic Medicine 12.5 (2016): 2855-2860.
Chicago
Xu, Z., Chi, P., Pan, J., Shen, S., Sun, Y., Wang, X., Lu, X."Knockdown of KLK11 inhibits cell proliferation and increases oxaliplatin sensitivity in human colorectal cancer". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2855-2860. https://doi.org/10.3892/etm.2016.3723