Open Access

Early identification of hypoxic‑ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy

  • Authors:
    • Lili Guo
    • Dehang Wang
    • Genji Bo
    • Hui Zhang
    • Weijing Tao
    • Ying Shi
  • View Affiliations

  • Published online on: September 21, 2016     https://doi.org/10.3892/etm.2016.3740
  • Pages: 2835-2842
  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Brain damage following a perinatal hypoxic‑ischemic encephalopathy (HIE) can be diagnosed by different techniques. The aim of the present study was to combine magnetic resonance (MR) imaging with proton MR spectroscopy in HIE diagnosis and to evaluate their correlation with outcome. A prospective observational cohort study was performed between February 2012 and February 2013. Consecutive newborns, 24 full‑term neonates with HIE (mild to moderate and severe group) and 5 normal neonates, were included. Two sequential MR studies were performed; a conventional MR imaging for observation in T1 weighted image (WI) and T2WI, and proton MR spectroscopy for observation in the left or right basal ganglia and thalamus. MR images were assessed and scored by two neuroradiologists who were blinded to the clinical condition of the infants. The mild to moderate group (n=13) and severe group (n=11) were similar in the visualization of punctate hyperintensity lesions on T1WI and brain edema on T2WI. The differences of N‑acetylaspartate/creatine (Cr), choline/Cr and lactate/Cr in the basal ganglia and thalamus in the HIE group were significantly different (P<0.05) compared with the control group, while no significant difference was identified between the mild to moderate and severe group (P>0.05). In conclusion, MR spectroscopy is a complementary tool for the diagnosis of HIE.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Guo L, Wang D, Bo G, Zhang H, Tao W and Shi Y: Early identification of hypoxic‑ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy. Exp Ther Med 12: 2835-2842, 2016.
APA
Guo, L., Wang, D., Bo, G., Zhang, H., Tao, W., & Shi, Y. (2016). Early identification of hypoxic‑ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy. Experimental and Therapeutic Medicine, 12, 2835-2842. https://doi.org/10.3892/etm.2016.3740
MLA
Guo, L., Wang, D., Bo, G., Zhang, H., Tao, W., Shi, Y."Early identification of hypoxic‑ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy". Experimental and Therapeutic Medicine 12.5 (2016): 2835-2842.
Chicago
Guo, L., Wang, D., Bo, G., Zhang, H., Tao, W., Shi, Y."Early identification of hypoxic‑ischemic encephalopathy by combination of magnetic resonance (MR) imaging and proton MR spectroscopy". Experimental and Therapeutic Medicine 12, no. 5 (2016): 2835-2842. https://doi.org/10.3892/etm.2016.3740