Open Access

Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study

  • Authors:
    • Qi-Jun Chen
    • Zhi-Yong Yang
    • Chun-You Wang
    • Li-Ming Dong
    • Yu-Shun Zhang
    • Chao Xie
    • Chang-Zhong Chen
    • Shi-Kai Zhu
    • Hong-Ji Yang
    • He-Shui Wu
    • Chong Yang
  • View Affiliations

  • Published online on: September 23, 2016     https://doi.org/10.3892/etm.2016.3744
  • Pages: 3213-3220
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In the present study, we investigated the effects of hydroxyethyl starch (HES) 130/0.4 on serum pro-inflammatory variables, immunologic variables, fluid balance (FB)-negative(-) rate and renal function in severe acute pancreatitis (SAP) patients. From October, 2007 to November, 2008, a total of 120 SAP patients were enrolled in this retrospective study. Fifty‑nine patients in the HES group received 6% HES 130/0.4 combined with crystalloid solution for fluid resuscitation (HES group). In the control group, 61 patients received only crystalloid solution after admission. Interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor (TNF)-α levels in serum were measured on days 1, 2, 4 and 8. The peripheral blood CD4+CD8+ T lymphocyte rates, serum BUN and Cr values were also measured on days 1, 4 and 8. Patients with FB(-) rates were recorded from day 1 to 8. Interaction term analysis (hospital stay and fluid resuscitation methods) based on mixed-effects regression model revealed significantly lower levels of IL-1 and TNF-α in the HES group compared with the control group. The difference in curve's risk ratio was not significant for IL-6, CD4+CD8+ T lymphocyte rate, BUN and Cr values (P>0.05). In the HES group, we detected a significantly higher rate of patients with FB(-) from day 4 to 8 (P<0.05). Thus, HES 130/0.4 resuscitation could decrease the IL-1 and IL-8 levels, shorten the duration of positive FB, and preserve the patient's immune status as well as renal function during the early phase of SAP.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Chen Q, Yang Z, Wang C, Dong L, Zhang Y, Xie C, Chen C, Zhu S, Yang H, Wu H, Wu H, et al: Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study. Exp Ther Med 12: 3213-3220, 2016.
APA
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C. ... Yang, C. (2016). Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study. Experimental and Therapeutic Medicine, 12, 3213-3220. https://doi.org/10.3892/etm.2016.3744
MLA
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C., Chen, C., Zhu, S., Yang, H., Wu, H., Yang, C."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study". Experimental and Therapeutic Medicine 12.5 (2016): 3213-3220.
Chicago
Chen, Q., Yang, Z., Wang, C., Dong, L., Zhang, Y., Xie, C., Chen, C., Zhu, S., Yang, H., Wu, H., Yang, C."Hydroxyethyl starch resuscitation downregulate pro-inflammatory cytokines in the early phase of severe acute pancreatitis: A retrospective study". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3213-3220. https://doi.org/10.3892/etm.2016.3744