Open Access

Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis

  • Authors:
    • Andrzej Prystupa
    • Anna Dąbrowska
    • Jarosław Jerzy Sak
    • Jerzy Tarach
    • Anna Toruń‑Jurkowska
    • Patrycja Lachowska‑Kotowska
    • Grzegorz Dzida
  • View Affiliations

  • Published online on: September 27, 2016     https://doi.org/10.3892/etm.2016.3754
  • Pages: 3464-3470
  • Copyright: © Prystupa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to evaluate the concentrations of fetuin-A, osteoprotegerin (OPG) and α-Klotho protein in patients with alcoholic cirrhosis at different stages of the disease, and to demonstrate that fetuin-A, osteoprotegin and α-Klotho may be used as markers of the severity of cirrhosis. A total of 54 patients with alcoholic liver cirrhosis treated in various hospitals in the Lublin region of Poland were randomly enrolled. The control group consisted of 18 healthy individuals without liver disease, who did not drink alcohol. Serum levels of fetuin‑A, OPG and α‑Klotho were measured by ELISA kits. Levels of fetuin‑A were significantly reduced in patients with alcoholic liver cirrhosis compared with the control group. OPG levels were higher in patients with alcoholic liver cirrhosis than in the controls, whereas the levels of α‑Klotho were comparable in the cirrhosis and control groups. No statistically significant differences in the concentrations of fetuin‑A, OPG and α‑Klotho protein were demonstrated according to type of liver cirrhosis. The findings of the present study revealed a significant negative correlation between the level of α‑Klotho protein and C‑reactive protein in the patients with alcoholic liver cirrhosis. Concentrations of fetuin‑A were lower, whereas those of OPG were higher, in the alcoholic liver cirrhosis group compared with the control group. Fetuin‑A, OPG and α‑Klotho may not be good indicators of liver cirrhosis severity. In conclusion, fetuin‑A and OPG may be used in the diagnosis of liver cirrhosis.
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November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Prystupa A, Dąbrowska A, Sak JJ, Tarach J, Toruń‑Jurkowska A, Lachowska‑Kotowska P and Dzida G: Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis. Exp Ther Med 12: 3464-3470, 2016.
APA
Prystupa, A., Dąbrowska, A., Sak, J.J., Tarach, J., Toruń‑Jurkowska, A., Lachowska‑Kotowska, P., & Dzida, G. (2016). Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis. Experimental and Therapeutic Medicine, 12, 3464-3470. https://doi.org/10.3892/etm.2016.3754
MLA
Prystupa, A., Dąbrowska, A., Sak, J. J., Tarach, J., Toruń‑Jurkowska, A., Lachowska‑Kotowska, P., Dzida, G."Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis". Experimental and Therapeutic Medicine 12.5 (2016): 3464-3470.
Chicago
Prystupa, A., Dąbrowska, A., Sak, J. J., Tarach, J., Toruń‑Jurkowska, A., Lachowska‑Kotowska, P., Dzida, G."Concentrations of fetuin-A, osteoprotegerin and α-Klotho in patients with alcoholic liver cirrhosis". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3464-3470. https://doi.org/10.3892/etm.2016.3754