Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease

  • Authors:
    • Jinyan Zhong
    • Xiaoying Chen
    • Nan Wu
    • Caijie Shen
    • Hanbin Cui
    • Weiping Du
    • Zhaoxia Zhang
    • Mingjun Feng
    • Junsong Liu
    • Shaoyi Lin
    • Lulu Zhang
    • Jian Wang
    • Xiaomin Chen
    • Shiwei Duan
  • View Affiliations

  • Published online on: September 28, 2016     https://doi.org/10.3892/etm.2016.3757
  • Pages: 3445-3449
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Catechol-O-methyltransferase (COMT) gene variation is known to be associated with the risk of acute coronary events. The purpose of the present study was to investigate the contribution of COMT promoter methylation towards the risk of coronary heart disease (CHD). COMT methylation was evaluated in 48 CHD cases and 48 well‑matched non‑CHD controls using bisulfite pyrosequencing technology. The results demonstrated that CHD cases had a significantly lower level of methylation at COMT CpG3 sites compared with the controls (33.77±5.71 vs. 36.42±5.00%; P=0.018). Further analysis, according to gender, showed that CpG3 methylation was associated with CHD in males (P=0.038) but not in females (P=0.253), suggesting that there is a gender disparity in the association between COMT methylation and CHD. In conclusion, it was determined that COMT CpG3 hypomethylation is associated with an increased risk of CHD in males.
View Figures
View References

Related Articles

Journal Cover

November-2016
Volume 12 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhong J, Chen X, Wu N, Shen C, Cui H, Du W, Zhang Z, Feng M, Liu J, Lin S, Lin S, et al: Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease. Exp Ther Med 12: 3445-3449, 2016.
APA
Zhong, J., Chen, X., Wu, N., Shen, C., Cui, H., Du, W. ... Duan, S. (2016). Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease. Experimental and Therapeutic Medicine, 12, 3445-3449. https://doi.org/10.3892/etm.2016.3757
MLA
Zhong, J., Chen, X., Wu, N., Shen, C., Cui, H., Du, W., Zhang, Z., Feng, M., Liu, J., Lin, S., Zhang, L., Wang, J., Chen, X., Duan, S."Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease". Experimental and Therapeutic Medicine 12.5 (2016): 3445-3449.
Chicago
Zhong, J., Chen, X., Wu, N., Shen, C., Cui, H., Du, W., Zhang, Z., Feng, M., Liu, J., Lin, S., Zhang, L., Wang, J., Chen, X., Duan, S."Catechol-O-methyltransferase promoter hypomethylation is associated with the risk of coronary heart disease". Experimental and Therapeutic Medicine 12, no. 5 (2016): 3445-3449. https://doi.org/10.3892/etm.2016.3757